Kosuke Kawaguchi

Kosuke Kawaguchi

I am a Research Fellow of Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School. I have the expertise, leadership, training, expertise, and motivation necessary to successfully carry out the proposed research project. I have a broad background in breast cancer biology, with specific training and expertise in clinical and translational research in breast cancer. 

Linkedin

www.linkedin.com/in/kosuke-kawaguchi-bba1a8145


Other Experience and Professional Memberships


Memberships

2009- American Society of Clinical Oncology

2012- American Association for Cancer Research

2017- Society for Immunotherapy of Cancer

2008- Japan Surgical Society

2008- Japanese Breast Cancer Society

2009- Japanese Society of Medical Oncology

2015- Japanese Society of Clinical Oncology


Board Certification

2012- Board Certified, General Surgeon (Japan, #1002838)

2014- Board Certified, Breast Cancer (Japan, #1281)


Honors

2015: European Society for Medical Oncology (ESMO) Asia 2015 travel grants for the young oncologist 

2015: San Antonio Breast Cancer Symposium (SABCS) travel grants for the young oncologist

2016: International Fellowship Grant from Alumni Association of Faculty of Medicine Sanjukai

2016: Japanese Journal of Breast Cancer Award for Excellence Paper

2016: American Society for Clinical Oncology (ASCO) annual meeting 2016 Merit Award

2016: Long-Term Fellowship for Research Abroad from The Kyoto University Foundation

2018: International Fellowship Grant from Kanae Foundation

2018: International Fellowship Grant from Japan Society for the Promotion of Science

Publications

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Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118
Gomes-Santos IL, Amoozgar Z, Kumar AS, Ho WW, Roh K, Talele NP, Curtis H, Kawaguchi K, Jain RK, Fukumura D
Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade.
Cancer Immunol Res. 2021;9(7):765-778 - PMID: 33839688 - PMCID: PMC8295193 - DOI: 10.1158/2326-6066.CIR-20-0499
Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M
Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
Nat Biotechnol. 2020;38(4):420-425 - PMID: 32042168 - PMCID: PMC7456461 - DOI: 10.1038/s41587-019-0404-8
Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK
Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
Sci Transl Med. 2018;10(432):ePub - PMID: 29540614 - PMCID: PMC5936748 - DOI: 10.1126/scitranslmed.aag0945
Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D
Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.
Proc Natl Acad Sci U S A. 2017;114(39):10455-10460 - PMID: 28900008 - PMCID: PMC5625928 - DOI: 10.1073/pnas.1710754114