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Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK

Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Cancer Res. 1995;55(22):5451-8 - PMID: 7585615

Kurose I, Miura S, Saito H, Tada S, Fukumura D, Higuchi H, Ishii H

Rat Kupffer cell-derived nitric oxide modulates induction of lymphokine-activated killer cell.
Gastroenterology. 1995;109(6):1958-68 - PMID: 7498662 - DOI: 10.1016/0016-5085(95)90764-5

Suzuki H, Miura S, Imaeda H, Suzuki M, Han JY, Mori M, Fukumura D, Tsuchiya M, Ishii H

Enhanced levels of chemiluminescence and platelet activating factor in urease-positive gastric ulcers.
Free Radic Biol Med. 1996;20(3):449-54 - PMID: 8720917 - DOI: 10.1016/0891-5849(96)02048-5

Suzuki M, Mori M, Miura S, Suematsu M, Fukumura D, Kimura H, Ishii H

Omeprazole attenuates oxygen-derived free radical production from human neutrophils.
Free Radic Biol Med. 1997;21(5):727-31 - PMID: 8891677 - DOI: 10.1016/0891-5849(96)00180-3

Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK

Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer Res. 1996;56(5):964-68 - PMID: 8640786

Fukumura D, Kurose I, Miura S, Serizawa H, Sekizuka E, Nagata H, Tsuchiya M, Ishii H

Role of endothelin-1 in repeated electrical stimulation-induced microcirculatory disturbance and mucosal damage in rat stomach.
J Gastroenterol Hepatol. 1996;11(3):279-85 - PMID: 8742927 - DOI: 10.1111/j.1440-1746.1996.tb00076.x

Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJ

Leukocyte-endothelial adhesion and angiogenesis in tumors.
Cancer Metastasis Rev. 1996;15(2):195-204 - PMID: 8842491 - DOI: 10.1007/BF00437472

Ward KA, Jain RK

Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia.
Int J Hyperthermia. 1988;4(3):223-50 - PMID: 3290346 - DOI: 10.3109/02656738809051100

Melder RJ, Salehi HA, Jain RK

Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.
Microvasc Res. 1995;50(1):35-44 - PMID: 7476578 - DOI: 10.1006/mvre.1995.1036

Townsend JG, Jain RK, Cashmore AR

In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.
J Pharm Sci. 1982;71(10):1102-5 - PMID: 7143204 - DOI: 10.1002/jps.2600711005

Dudar TE, Jain RK

Differential response of normal and tumor microcirculation to hyperthermia.
Cancer Res. 1984;44(2):605-12 - PMID: 6692365

Peloso R, Tuma DT, Jain RK

Dielectric properties of solid tumors during normothermia and hyperthermia.
IEEE Trans Biomed Eng. 1984;31(11):725-8 - PMID: 6500596 - DOI: 10.1109/TBME.1984.325399

Dimitrov DS, Jain RK

Membrane stability.
Biochim Biophys Acta. 1984;779(4):437-68 - PMID: 6391549 - DOI: 10.1016/0304-4157(84)90020-0

Gerlowski LE, Jain RK

Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.
Int J Microcirc Clin Exp. 1986;4(4):363-72 - PMID: 4086191

Dimitrov DS, Zhelev DV, Jain RK

Stability of membrane systems modeled as multilayered viscoelastic films.
J Theor Biol. 1985;113(2):353-77 - PMID: 3999781 - DOI: 10.1016/s0022-5193(85)80232-0

Ward-Hartley KA, Jain RK

Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.
Cancer Res. 1987;47(2):371-7 - PMID: 3791228

Traykov TT, Jain RK

Effect of glucose and galactose on red blood cell membrane deformability.
Int J Microcirc Clin Exp. 1987;6(1):35-44 - PMID: 3583577

Jain RK, Gerlowski LE

Extravascular transport in normal and tumor tissues.
Crit Rev Oncol Hematol. 1986;5(2):115-70 - PMID: 3521923 - DOI: 10.1016/s1040-8428(86)80023-3

Jain RK

Transport of molecules across tumor vasculature.
Cancer Metastasis Rev. 1988;6(4):559-93 - PMID: 3327633 - DOI: 10.1007/BF00047468

Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.
Lab Invest. 1994;71(2):300-7 - PMID: 7521447

Jain RK

Determinants of tumor blood flow: a review.
Cancer Res. 1988;48(10):2641-58 - PMID: 3282647

Chary SR, Jain RK

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.
Proc Natl Acad Sci U S A. 1989;86(14):5385-9 - PMID: 2748592 - PMCID: PMC297627 - DOI: 10.1073/pnas.86.14.5385

Sevick EM, Jain RK

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.
Cancer Res. 1989;49(13):3506-12 - PMID: 2731172

Jain RK

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
J Natl Cancer Inst. 1989;81(8):570-6 - PMID: 2649688 - DOI: 10.1093/jnci/81.8.570

Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Microvasc Res. 1989;37(1):77-104 - PMID: 2646512 - DOI: 10.1016/0026-2862(89)90074-5

Baxter LT, Jain RK, Svensjö E

Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.
Microvasc Res. 1987;34(3):336-48 - PMID: 2448593 - DOI: 10.1016/0026-2862(87)90066-5

Jain RK

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.
Cancer Res. 1990;50(3 Suppl):814s-819s - PMID: 2404582

Clauss MA, Jain RK

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Cancer Res. 1990;50(12):3487-92 - PMID: 2340499

Jain RK

Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Cancer Metastasis Rev. 1990;9(3):253-66 - PMID: 2292138 - DOI: 10.1007/BF00046364

Kaufman EN, Jain RK

Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.
Biophys J. 1990;58(4):873-85 - PMID: 2248992 - PMCID: PMC1281033 - DOI: 10.1016/S0006-3495(90)82432-2

Jain RK

Tumor physiology and antibody delivery.
Front Radiat Ther Oncol. 1990;24:32-46; discussion 64-8 - PMID: 2187763

Martin GR, Jain RK

Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.
Microvasc Res. 1993;46(2):216-30 - PMID: 8246820 - DOI: 10.1006/mvre.1993.1048

Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice.
Acta Orthop Scand. 1996;67(4):383-8 - PMID: 8792744 - DOI: 10.3109/17453679609002336

Zhu H, Melder RJ, Baxter LT, Jain RK

Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Cancer Res. 1996;56(16):3771-81 - PMID: 8706023

Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.
Am J Pathol. 1996;149(1):59-71 - PMID: 8686763 - PMCID: PMC1865247

Nozue M, Lee I, Manning JM, Manning LR, Jain RK

Oxygenation in tumors by modified hemoglobins.
J Surg Oncol. 1996;62(2):109-14 - PMID: 8649036 - DOI: 10.1002/(SICI)1096-9098(199606)62:2<109::AID-JSO6>3.0.CO;2-C

Jain RK

Delivery of molecular medicine to solid tumors.
Science. 1996;271(5252):1079-80 - PMID: 8599082 - DOI: 10.1126/science.271.5252.1079

Leunig M, Yuan F, Gerweck LE, Berk DA, Jain RK

Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach.
Res Exp Med (Berl). 1996;195(5):275-88 - PMID: 8578003 - DOI: 10.1007/BF02576798

Eskey CJ, Koretsky AP, Domach MM, Jain RK

Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.
Proc Natl Acad Sci U S A. 1993;90(7):2646-50 - PMID: 8464871 - PMCID: PMC46152 - DOI: 10.1073/pnas.90.7.2646

Yuan F, Leunig M, Berk DA, Jain RK

Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.
Microvasc Res. 1993;45(3):269-89 - PMID: 8321142 - DOI: 10.1006/mvre.1993.1024

Berk DA, Yuan F, Leunig M, Jain RK

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.
Biophys J. 1993;65(6):2428-36 - PMID: 8312481 - PMCID: PMC1225983 - DOI: 10.1016/S0006-3495(93)81326-2

Leunig M, Goetz AE, Gamarra F, Zetterer G, Messmer K, Jain RK

Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.
Br J Cancer. 1994;69(1):101-3 - PMID: 8286189 - PMCID: PMC1968758 - DOI: 10.1038/bjc.1994.15

Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK

Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.
Cancer Res. 1993;53(24):5867-71 - PMID: 8261395

Ward KA, DiPette DJ, Held TN, Jain RK

Effect of intravenous versus intraperitoneal glucose injection on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1991;51(13):3612-6 - PMID: 2054796

Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK

Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.
J Natl Cancer Inst. 1994;86(4):293-9 - PMID: 8158684 - DOI: 10.1093/jnci/86.4.293

Baxter LT, Zhu H, Mackensen DG, Jain RK

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Cancer Res. 1994;54(6):1517-28 - PMID: 8137258

Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.
Proc Natl Acad Sci U S A. 1994;91(6):2081-5 - PMID: 8134352 - PMCID: PMC43313 - DOI: 10.1073/pnas.91.6.2081

Jain RK

Barriers to drug delivery in solid tumors.
Sci Am. 1994;271(1):58-65 - PMID: 8066425 - DOI: 10.1038/scientificamerican0794-58

Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Cancer Res. 1994;54(13):3352-6 - PMID: 8012948

Hamberg LM, Kristjansen PE, Hunter GJ, Wolf GL, Jain RK

Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.
Cancer Res. 1994;54(23):6032-6 - PMID: 7954440
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