• 2015 Annual Retreat

    Annual Retreat. Museum of Science Boston.

  • Normalization

    A major goal is to understand the mechanisms underlying the temporal and spatial heterogeneities in tumor vasculature by studying angiogenesis, vascular collapse, intermittent flow, and maturation of vascular networks.

  • Intravital Imaging

    In the past 20 years, we made several technical innovations in imaging and transport measurements. Our laboratory has a long-standing tradition of novel technique development and application.

  • Blood Vessels

    A major challenge is to quantify blood vessel structure and function from intravital images

  • Mechanisms of vascular anastomosis

    Angiogenic blood vessels have to connect to initiate perfusion

  • Tumor Microenvironment

    Tumors are not just cancer cells driven by genetic mutations; stromal cells, matrix and biochemicals in microenvironment can contribute to progression

  • Tumor mechanobiology

    Forces produced during tumor growth can affect pathophysiology

  • Mathematical modeling

    Mathematical models allow integration of existing information and help guide treatment

  • Lymphatic physiology

    Lymphatic function is altered around solid tumors, potentially enabling growth

  • Optical frequency domain imaging

    Optical frequency domain imaging detects blood flow, allowing non-invasive visualization deep within tumors

  • Relieving stress in tumors

    Growth-induced mechanical compression can favor tumor growth; relieving this stress improves therapy

  • Cellular mechanisms of metastasis

    Dissemination of tumor cells from a primary tumor is a crucial step for disease progression, but is poorly-understood


Research: Further mechanistic understanding of the vascular, interstitial and cellular barriers to the delivery and effectiveness of molecular medicine to solid tumors. Develop and test new strategies to overcome the physiological barriers for improved detection and treatment of primary and metastatic tumors in mice.

Translation: Translate these strategies from bench to bedside.

Education: Educate basic scientists, bioengineers, and oncologists in the integrative biology of cancer.

Annual Report


“Emerging strategies for delivering antiangiogenic therapies to primary and metastatic brain tumors” Advanced Drug Delivery Reviews 2017.

“MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma” J. Neurooncol. 2017.

“Engineering and physical sciences in oncology: challenges and opportunities.” Nature Reviews Cancer 2017.

“A cerebellar window for intravital imaging of normal and disease states in mice.” Nature Protocols 2017.

“Solid stress and elastic energy as measures of tumour mechanopathology.” Nature Biomedical Engineering 2016.

Revised on 2017-12-20 20:17:03 UTC