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Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell J, Vander Heiden MG
Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
Elife. 2024;13:ePub - PMID: 38787918 - PMCID: PMC11126308 - DOI: 10.7554/eLife.95652
Liu Z, Ma K, Jia Q, Yang Y, Fan P, Wang Y, Wang J, Sun J, Sun L, Shi H, Sun L, Zhu B, Xu W, Zhang L, Jain RK, Qin S, Huang Y
Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer
10.1136/bmjonc-2024-000473. 2024;3:e000473 - DOI: 10.1136/bmjonc-2024-000473
Banerjee S, Booth CM, Bruera E, Büchler MW, Drilon A, Fry TJ, Ghobrial IM, Gianni L, Jain RK, Kroemer G, Llovet JM, Long GV, Pantel K, Pritchard-Jones K, Scher HI, Tabernero J, Weichselbaum RR, Weller M, Wu YL
Two decades of advances in clinical oncology - lessons learned and future directions.
Nat Rev Clin Oncol. 2024;:ePub - PMID: 39354161 - DOI: 10.1038/s41571-024-00945-4
Ho AY, Shiao S, Kobald SA, Chen J, Duda DG, Ly A, Bossuyt V, Cho HL, Arnold B, Knott S, Gupta GP, McAndrew P, Karlan S, Tighiouart M, Muzikansky A, Basho R, McArthur H
PEARL: A Phase Ib/II Biomarker Study of Adding Radiation Therapy to Pembrolizumab Before Neoadjuvant Chemotherapy in Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer.
J Clin Oncol. 2024;:JCO2400003 - PMID: 39298718 - DOI: 10.1200/JCO.24.00003
Mohamed YI, Lee SS, Demir T, Chamseddine S, Hu ZI, Xiao L, Elsayes K, Morris JS, Wolff RA, Hiatia R, Qayyum A, Rashid A, Duda DG, Yao JC, LaPelusa M, Koay EJ, Mahvash A, Al Azzam A, Dumbrava EE, Hassan M, Amin HM, Kaseb AO
Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab.
Cancer Biomark. 2024;41(1):83-91 - PMID: 39269823 - DOI: 10.3233/CBM-230431
Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LK, Singh A, Fu J, Waterton SK, Cheng YC, Roberge S, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA
Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer.
bioRxiv. 2024;:ePub - PMID: 39257788 - PMCID: PMC11383995 - DOI: 10.1101/2024.08.28.609802
Lei PJ, Fraser C, Jones D, Ubellacker JM, Padera TP
Lymphatic system regulation of anti-cancer immunity and metastasis.
Front Immunol. 2024;15:1449291 - PMID: 39211044 - PMCID: PMC11357954 - DOI: 10.3389/fimmu.2024.1449291
Sivanand S, Gultekin Y, Winter PS, Vermeulen SY, Tchourine KM, Abbott KL, Danai LV, Gourgue F, Do BT, Crowder K, Kunchok T, Lau AN, Darnell AM, Jefferson A, Morita S, Duda DG, Aguirre AJ, Wolpin BM, Henning N, Spanoudaki V, Maiorino L, Irvine DJ, Yilmaz OH, Lewis CA, Vitkup D, Shalek AK, Vander Heiden MG
Cancer tissue of origin constrains the growth and metabolism of metastases.
Nat Metab. 2024;6(9):1668-1681 - PMID: 39160333 - DOI: 10.1038/s42255-024-01105-9
Datta M, Via LE, Dartois V, Xu L, Barry CE, Jain RK
Leveraging insights from cancer to improve tuberculosis therapy.
Trends Mol Med. 2024;:ePub - PMID: 39142973 - DOI: 10.1016/j.molmed.2024.07.011
Dogra P, Shinglot V, Ruiz-Ramírez J, Cave J, Butner JD, Schiavone C, Duda DG, Kaseb AO, Chung C, Koay EJ, Cristini V, Ozpolat B, Calin GA, Wang Z
Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer.
Mol Cancer. 2024;23(1):156 - PMID: 39095771 - PMCID: PMC11295620 - DOI: 10.1186/s12943-024-02060-5
Skelton WP, Masur J, Thomas J, Fallah P, Jain RK, Ravi P, Mantia C, McGregor BA, Nuzzo PV, Adib E, Zarif TE, Preston MA, Clinton TN, Li R, Steele GS, Kassouf W, Freeman D, Pond GR, Jain RK, Sonpavde GP
Impact of Angiotensin Converting Enzyme Inhibitors on Pathologic Complete Response With Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer.
Clin Genitourin Cancer. 2024;22(5):102143 - PMID: 39032202 - DOI: 10.1016/j.clgc.2024.102143
Lu S, Yin Z, Chen J, Wu L, Sun Y, Gao X, Huang P, Jordan JT, Plotkin SR, Xu L
Integrating Ataxia Evaluation into Tumor-Induced Hearing Loss Model to Comprehensively Study NF2-Related Schwannomatosis.
Cancers (Basel). 2024;16(11):ePub - PMID: 38893082 - PMCID: PMC11171041 - DOI: 10.3390/cancers16111961
Li H, Zhang J, Padera TP, Baish JW, Munn LL
Fluid dynamics and leukocyte transit in the lymphatic system.
PNAS Nexus. 2024;3(6):pgae195 - PMID: 38827815 - PMCID: PMC11141778 - DOI: 10.1093/pnasnexus/pgae195
Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Munn LL, Jain RK, Stylianopoulos T
Dynamic heterogeneity in COVID-19: Insights from a mathematical model.
PLoS One. 2024;19(5):e0301780 - PMID: 38820409 - PMCID: PMC11142552 - DOI: 10.1371/journal.pone.0301780
Saylor PJ, Kozin SV, Matsui A, Goldberg SI, Aoki S, Shigeta K, Mamessier E, Smith MR, Dror Michaelson M, Lee RJ, Duda DG
The radiopharmaceutical radium-223 has immunomodulatory effects in patients and facilitates anti-programmed death receptor-1 therapy in murine models of bone metastatic prostate cancer.
Radiother Oncol. 2024;192:110091 - PMID: 38224917 - PMCID: PMC10905770 - DOI: 10.1016/j.radonc.2024.110091
Razavi MS, Ruscic KJ, Korn EG, Marquez M, Houle TT, Singhal D, Munn LL, Padera TP
A Multiresolution Approach with Method-Informed Statistical Analysis for Quantifying Lymphatic Pumping Dynamics.
bioRxiv. 2024;:ePub - PMID: 38712181 - PMCID: PMC11071510 - DOI: 10.1101/2024.04.24.590950
Razavi MS, Munn LL, Padera TP
Mechanics of Lymphatic Pumping and Lymphatic Function.
Cold Spring Harb Perspect Med. 2024;:ePub - PMID: 38692743 - DOI: 10.1101/cshperspect.a041171
Gruionu G, Baish J, McMahon S, Blauvelt D, Gruionu LG, Lenco MO, Vakoc BJ, Padera TP, Munn LL
Experimental and theoretical model of microvascular network remodeling and blood flow redistribution following minimally invasive microvessel laser ablation.
Sci Rep. 2024;14(1):8767 - PMID: 38627467 - PMCID: PMC11021487 - DOI: 10.1038/s41598-024-59296-w
Wu B, Tapadar S, Ruan Z, Sun CQ, Arnold RS, Olugbami JO, Johnston A, Arunsi U, Gaul DA, Petros JA, Kobayashi T, Duda DG, Oyelere AK
A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy.
bioRxiv. 2024;:ePub - PMID: 38585757 - PMCID: PMC10996603 - DOI: 10.1101/2024.03.27.587062
Dogra P, Shinglot V, Ruiz-Ramírez J, Cave J, Butner JD, Schiavone C, Duda DG, Kaseb AO, Chung C, Koay EJ, Cristini V, Ozpolat B, Calin GA, Wang Z
Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer.
medRxiv. 2024;:ePub - PMID: 38559070 - PMCID: PMC10980136 - DOI: 10.1101/2024.03.14.24304306
Datta M, Via LE, Dartois V, Weiner DM, Zimmerman M, Kaya F, Walker AM, Fleegle JD, Raplee ID, McNinch C, Zarodniuk M, Kamoun WS, Yue C, Kumar AS, Subudhi S, Xu L, Barry CE, Jain RK
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
Proc Natl Acad Sci U S A. 2024;121(14):e2321336121 - PMID: 38530888 - PMCID: PMC10998582 - DOI: 10.1073/pnas.2321336121
Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Stylianopoulos T, Munn LL, Jain RK
In silico clinical studies for optimal COVID-19 vaccination schedules in patients with cancer.
Cell Rep Med. 2024;5(3):101436 - PMID: 38508146 - PMCID: PMC10982978 - DOI: 10.1016/j.xcrm.2024.101436
Gomes-Santos IL, Kumar AS, Hausmann F, Meyer MN, Shiferaw SZ, Amoozgar Z, Jain RK, Fukumura D
Exercise intensity governs tumor control in mice with breast cancer.
Front Immunol. 2024;15:1339232 - PMID: 38495879 - PMCID: PMC10940460 - DOI: 10.3389/fimmu.2024.1339232
Chamseddine S, LaPelusa M, Xiao L, Mohamed YI, Lee SS, Hu ZI, Hatia RI, Hassan M, Yao JC, Duda DG, Datar S, Amin HM, Kaseb AO
Plasma Growth Hormone as a Prognostic Biomarker to Durvalumab and Tremelimumab in Patients with Advanced Hepatocellular Carcinoma.
J Hepatocell Carcinoma. 2024;11:455-461 - PMID: 38463542 - PMCID: PMC10921889 - DOI: 10.2147/JHC.S452564
Wolf B, Jain RK
Unraveling a hidden player in lymphovascular invasion in bladder cancer.
Cancer Cell. 2024;42(4):509-512 - PMID: 38458186 - DOI: 10.1016/j.ccell.2024.02.007
Datta M, Kennedy M, Siri S, Via LE, Baish JW, Xu L, Dartois V, Barry CE, Jain RK
Mathematical model of oxygen, nutrient, and drug transport in Tuberculosis Granulomas.
PLoS Comput Biol. 2024;20(2):e1011847 - PMID: 38335224 - PMCID: PMC10883541 - DOI: 10.1371/journal.pcbi.1011847
Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin SM, Matsui A, Hernandez A, Pu Z, Halvorsen S, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Sassi S, Bardeesy N, Ho WJ, Jain RK, Duda DG
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
Cancer Immunol Res. 2024;12(4):400-412 - PMID: 38260999 - PMCID: PMC10985468 - DOI: 10.1158/2326-6066.CIR-23-0486
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