Munn Lab

O'Melia MJ, Sierra-Davidson K, Robert MA, Menzel L, Liu L, Lei PJ, Munn LL, Padera TP, Cohen S

The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy.
bioRxiv. 2025;:ePub - PMID: 41040229 - PMCID: PMC12485707 - DOI: 10.1101/2025.09.22.677905

O'Melia MJ, Menzel L, Lei PJ, Zhou H, Contreras-Alvarado N, Rajotte JJ, Liu L, Nikmaneshi MR, Baish JW, Ubellacker JM, Boland GM, Cohen S, Munn LL, Padera TP

Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapy.
bioRxiv. 2025;:ePub - PMID: 41000874 - PMCID: PMC12458325 - DOI: 10.1101/2025.09.17.676884

Krishnan S, Lee S, Amoozgar Z, Subudhi S, Srinivasan Kumar A, Posada JM, Lindeman N, Lei P, Duquette M, Steinbuch S, Charabati M, Huang P, Andersson P, Datta M, Munn LL, Fukumura D, Jain RK

Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma.
Proc Natl Acad Sci U S A. 2025;122(38):e2414941122 - PMID: 40953263 - PMCID: PMC12478157 - DOI: 10.1073/pnas.2414941122

Hadjigeorgiou AG, Munn LL, Stylianopoulos T, Jain RK

Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors.
bioRxiv. 2025;:ePub - PMID: 40894718 - PMCID: PMC12393523 - DOI: 10.1101/2025.08.20.671229

Munn LL, Jain RK

Challenges and opportunities for the next generation of computational tumor models.
PLoS Biol. 2025;23(7):e3003269 - PMID: 40700394 - PMCID: PMC12286354 - DOI: 10.1371/journal.pbio.3003269

Razavi MS, Ruscic KJ, Korn EG, Marquez M, Houle TT, Singhal D, Munn LL, Padera TP

A multiresolution approach with method-informed statistical analysis for quantifying lymphatic pumping dynamics.
Npj Imaging. 2025;3(1):2 - PMID: 40604254 - PMCID: PMC12091688 - DOI: 10.1038/s44303-024-00061-z

Voutouri C, Munn LL, Stylianopoulos T, Jain RK

Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions.
PLoS Comput Biol. 2025;21(6):e1013163 - PMID: 40504865 - PMCID: PMC12201673 - DOI: 10.1371/journal.pcbi.1013163

Nia HT, Datta M, Kumar AS, Siri S, Ferraro GB, Chatterjee S, McHugh JM, Ng PR, West TR, Rapalino O, Choi BD, Nahed BV, Munn LL, Jain RK

Solid stress estimations via intraoperative 3D navigation in patients with brain tumors.
Clin Cancer Res. 2025;31(16):3571-3580 - PMID: 40495423 - PMCID: PMC12351280 - DOI: 10.1158/1078-0432.CCR-24-4159

Hadjigeorgiou AG, Harkos C, Mishra AK, Morad G, Johnson SB, Ajami NJ, Wargo JA, Munn LL, Stylianopoulos T, Jain RK

Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy.
Cancer Res. 2025;85(16):3139-3155 - PMID: 40439571 - PMCID: PMC12355177 - DOI: 10.1158/0008-5472.CAN-24-2232

Munn LL

The cellular dance that splits vessels.
Proc Natl Acad Sci U S A. 2025;122(22):e2508260122 - PMID: 40424133 - PMCID: PMC12146740 - DOI: 10.1073/pnas.2508260122

Menzel L, Zschummel M, O'Melia MJ, Zhou H, Lei PJ, Liu L, Sen DR, Munn LL, Padera TP

Lymph nodes link sex-biased immune aging to compromised antigen recognition.
bioRxiv. 2025;:ePub - PMID: 39990447 - PMCID: PMC11844512 - DOI: 10.1101/2025.02.11.637693

Nia HT, Munn LL, Jain RK

Probing the physical hallmarks of cancer.
Nat Methods. 2025;22(9):1800-1818 - PMID: 39815103 - DOI: 10.1038/s41592-024-02564-4
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