Meghan O'Melia

Meghan O'Melia

Publications

Hide

Menzel L, Zschummel M, O'Melia MJ, Zhou H, Lei PJ, Liu L, Sen DR, Munn LL, Padera TP

Lymph nodes link sex-biased immune aging to compromised antigen recognition.
bioRxiv. 2025;:ePub - PMID: 39990447 - PMCID: PMC11844512 - DOI: 10.1101/2025.02.11.637693

Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Razavi MS, Zhou H, Menzel L, Huang L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Kurpios NA, Ubellacker JM, Padera TP

Aging-induced changes in lymphatic muscle cell transcriptomes are associated with reduced pumping of peripheral collecting lymphatic vessels in mice.
Dev Cell. 2024;60(7):1118-1133.e5 - PMID: 39731913 - PMCID: PMC11981864 - DOI: 10.1016/j.devcel.2024.12.010

Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Arroyo-Ataz G, Razavi MS, Zhou H, Menzel L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Ubellacker JM, Jones D, Padera TP

Lymphatic muscle cells are unique cells that undergo aging induced changes.
bioRxiv. 2023;:ePub - PMID: 38014141 - PMCID: PMC10680808 - DOI: 10.1101/2023.11.18.567621

Zhou H, Baish JW, O'Melia MJ, Darragh LB, Specht E, Czapla J, Lei PJ, Menzel L, Rajotte JJ, Nikmaneshi MR, Razavi MS, Heiden MGV, Ubellacker JM, Munn LL, Boland GM, Cohen S, Karam SD, Padera TP

Cancer immunotherapy responses persist after lymph node resection.
bioRxiv. 2023;:ePub - PMID: 37781599 - PMCID: PMC10541098 - DOI: 10.1101/2023.09.19.558262

Lei PJ, Pereira ER, Andersson P, Amoozgar Z, Van Wijnbergen JW, O'Melia MJ, Zhou H, Chatterjee S, Ho WW, Posada JM, Kumar AS, Morita S, Menzel L, Chung C, Ergin I, Jones D, Huang P, Beyaz S, Padera TP

Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes.
J Exp Med. 2023;220(9):ePub - PMID: 37341991 - PMCID: PMC10286805 - DOI: 10.1084/jem.20221847