Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
J Clin Invest. 2017;127(8):3039-3051 - PMID: 28691930 - PMCID: PMC5531423 - DOI: 10.1172/JCI93182

Pinter M, Weinmann A, Wörns MA, Hucke F, Bota S, Marquardt JU, Duda DG, Jain RK, Galle PR, Trauner M, Peck-Radosavljevic M, Sieghart W

Use of inhibitors of the renin-angiotensin system is associated with longer survival in patients with hepatocellular carcinoma.
United European Gastroenterol J. 2017;5(7):987-996 - PMID: 29163965 - PMCID: PMC5676550 - DOI: 10.1177/2050640617695698

Rowlands CJ, Park D, Bruns OT, Piatkevich KD, Fukumura D, Jain RK, Bawendi MG, Boyden ES, So PT

Wide-field three-photon excitation in biological samples.
Light Sci Appl. 2017;6:e16255 - PMID: 29152380 - PMCID: PMC5687557 - DOI: 10.1038/lsa.2016.255

Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski FB, Carr JA, Rowlands CJ, Wilson MWB, Chen O, Wei H, Hwang GW, Montana DM, Coropceanu I, Achorn OB, Kloepper J, Heeren J, So PTC, Fukumura D, Jensen KF, Jain RK, Bawendi MG

Next-generation in vivo optical imaging with short-wave infrared quantum dots.
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Li W, Yang W, Liu Y, Chen S, Chin S, Qi X, Zhao Y, Liu H, Wang J, Mei X, Huang P, Xu D

MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.
Oncotarget. 2017;8(43):73938-73946 - PMID: 29088758 - PMCID: PMC5650313 - DOI: 10.18632/oncotarget.17881

Mitchell MJ, Jain RK, Langer R

Engineering and physical sciences in oncology: challenges and opportunities.
Nat Rev Cancer. 2017;17(11):659-675 - PMID: 29026204 - PMCID: PMC5683724 - DOI: 10.1038/nrc.2017.83

Pinter M, Jain RK

Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy.
Sci Transl Med. 2017;9(410):ePub - PMID: 28978752 - PMCID: PMC5928511 - DOI: 10.1126/scitranslmed.aan5616

Askoxylakis V, Badeaux M, Roberge S, Batista A, Kirkpatrick N, Snuderl M, Amoozgar Z, Seano G, Ferraro GB, Chatterjee S, Xu L, Fukumura D, Duda DG, Jain RK

A cerebellar window for intravital imaging of normal and disease states in mice.
Nat Protoc. 2017;12(11):2251-2262 - PMID: 28981123 - PMCID: PMC5918134 - DOI: 10.1038/nprot.2017.101

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK

Solid stress and elastic energy as measures of tumour mechanopathology.
Nat Biomed Eng. 2016;1:ePub - PMID: 28966873 - PMCID: PMC5621647 - DOI: 10.1038/s41551-016-0004

Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D

Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.
Proc Natl Acad Sci U S A. 2017;114(39):10455-10460 - PMID: 28900008 - PMCID: PMC5625928 - DOI: 10.1073/pnas.1710754114

Wang X, Freire Valls A, Schermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann L, Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C

YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.
Dev Cell. 2017;42(5):462-478.e7 - PMID: 28867486 - DOI: 10.1016/j.devcel.2017.08.002

Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J

Gut microbiota is critical for the induction of chemotherapy-induced pain.
Nat Neurosci. 2017;20(9):1213-1216 - PMID: 28714953 - PMCID: PMC5575957 - DOI: 10.1038/nn.4606

Yokoda R, Nagalo BM, Vernon B, Oklu R, Albadawi H, DeLeon TT, Zhou Y, Egan JB, Duda DG, Borad MJ

Oncolytic virus delivery: from nano-pharmacodynamics to enhanced oncolytic effect.
Oncolytic Virother. 2017;6:39-49 - PMID: 29184854 - PMCID: PMC5687448 - DOI: 10.2147/OV.S145262

Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK

Origins of lymphatic and distant metastases in human colorectal cancer.
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Meijer EFJ, Jeong HS, Pereira ER, Ruggieri TA, Blatter C, Vakoc BJ, Padera TP

Murine chronic lymph node window for longitudinal intravital lymph node imaging.
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Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, Nellore V, Kongpetch S, Ng AWT, Ng LM, Choo SP, Myint SS, Thanan R, Nagarajan S, Lim WK, Ng CCY, Boot A, Liu M, Ong CK, Rajasegaran V, Lie S, Lim AST, Lim TH, Tan J, Loh JL, McPherson JR, Khuntikeo N, Bhudhisawasdi V, Yongvanit P, Wongkham S, Totoki Y, Nakamura H, Arai Y, Yamasaki S, Chow PKH, Chung AYF, Ooi LLPJ, Lim KH, Dima S, Duda DG, Popescu I, Broet P, Hsieh SY, Yu MC, Scarpa A, Lai J, Luo DX, Carvalho AL, Vettore AL, Rhee H, Park YN, Alexandrov L, Gordan R, Rozen SG, Shibata T, Pairojkul C, Teh BT, Tan P

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.
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Askoxylakis V, Arvanitis CD, Wong CSF, Ferraro GB, Jain RK

Emerging Strategies for Delivering Antiangiogenic Therapies to Primary and Metastatic Brain Tumors.
Adv Drug Deliv Rev. 2017;119:159-174 - PMID: 28648712 - PMCID: PMC12051390 - DOI: 10.1016/j.addr.2017.06.011

Askoxylakis V, Kodack DP, Ferraro GB, Jain RK

Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?
Breast Cancer Res Treat. 2017;165(2):467-468 - PMID: 28643019 - DOI: 10.1007/s10549-017-4351-0

Levin VA, Chan J, Datta M, Yee JL, Jain RK

Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab.
J Neurooncol. 2017;134(2):325-330 - PMID: 28631191 - DOI: 10.1007/s11060-017-2528-3

Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, Fernandez-Del Castillo C, Downes M, Evans RM, Michaelson J, Ferrone CR, Boucher Y, Jain RK

Use of Angiotensin System Inhibitors is Associated with Immune Activation and Longer Survival in Non-Metastatic Pancreatic Ductal Adenocarcinoma.
Clin Cancer Res. 2017;23(19):5959-5969 - PMID: 28600474 - PMCID: PMC5856249 - DOI: 10.1158/1078-0432.CCR-17-0256

Li W, Yang W, Liu Y, Chen S, Chin S, Qi X, Zhao Y, Liu H, Wang J, Mei X, Huang P, Xu D

MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.
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Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, Wong CSF, Kloepper J, Das R, Tam A, Tanboon J, Duda DG, Miller CR, Siegel MB, Anders CK, Sanders M, Estrada MV, Schlegel R, Arteaga CL, Brachtel E, Huang A, Fukumura D, Engelman JA, Jain RK

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.
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David P. Kodack, Vasileios Askoxylakis, Gino B. Ferraro, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram Shankaraiah, Z. Alexander Cao, Rakesh R. Ramjiawan, Divya Bezwada, Bhushankumar Patel, Yongchul Song, Carlotta Costa, Kamila Naxerova, Christina S. F. Wong, Jonas Kloepper,
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The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
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De Palma M, Jain RK

CD4(+) T Cell Activation and Vascular Normalization: Two Sides of the Same Coin?
Immunity. 2017;46(5):773-775 - PMID: 28514684 - DOI: 10.1016/j.immuni.2017.04.015

Munn LL, Jain RK

The forces of cancer
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Botezatu A, Bleotu C, Nastase A, Anton G, Bacalbasa N, Duda D, Dima SO, Popescu I

Epigenetic Silencing of GNMT Gene in Pancreatic Adenocarcinoma.
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Ng MR, Jain RK

Hypoxia-induced DNA hypermethylation: another reason to normalize tumor vessels
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Bucur O, Almasan A, Nikolajczyk BS, Nicolson GL, Lawler J, Velculescu VE, Draghici S, Leabu M, Avram D, Bucur I, Calautti E, Calin GA, Chauhan SC, Ciubotaru M, Constantinescu SN, Datta D, Duda DG, Friedman MT, Galardy PJ, Harris BT, Huarte M, Khalil AM, Marchetti D, Movileanu L, Nat R, Nucera C, Popa-Wagner A, Stancu AL, Zhu S, Liehn EA

Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry.
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Saito Y, Sunamura M, Motoi F, Abe H, Egawa S, Duda DG, Hoshida T, Fukuyama S, Hamada H, Matsuno S

Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region.
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Teague TK, Munn L, Zygourakis K, McIntyre BW

Analysis of lymphocyte activation and proliferation by video microscopy and digital imaging.
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Fidler IJ, Yoneda J, Herrera C, Wood J, Xu L

Specific keynote: molecular determinants of angiogenesis in ovarian cancer.
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Stroh M, Duda DG, Takimoto CH, Yamazaki S, Vicini P

Translation of anticancer efficacy from nonclinical models to the clinic.
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Garkavtsev IV, Tsvetkova TG, Yegolina NA, Gudkov AV

Variability of human rRNA genes: inheritance and nonrandom chromosomal distribution of structural variants of nontranscribed spacer sequences.
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Gerweck LE, Huang P, Lu HM, Paganetti H, Zhou Y

Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons.
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Friedrich EB, Tager AM, Liu E, Pettersson A, Owman C, Munn L, Luster AD, Gerszten RE

Mechanisms of leukotriene B4--triggered monocyte adhesion.
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Jones R, Capen D, Jacobson M, Munn L

PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension.
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Meijer EF, Blatter C, Chen IX, Bouta E, Jones D, Pereira ER, Jung K, Vakoc BJ, Baish JW, Padera TP

Lymph node effective vascular permeability and chemotherapy uptake.
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DiPette D, Ward-Hartley K, Jain RK

Effect of hyperglycemia on systemic hemodynamics and blood flow rate in normal and neoplastic tissues in rats
Cancer Res. 1986;46:6299-6304

Lee EQ, Kaley TJ, Duda DG, Schiff D, Lassman AB, Wong ET, Mikkelsen T, Purow BW, Muzikansky A, Ancukiewicz M, Huse JT, Ramkissoon S, Drappatz J, Norden AD, Beroukhim R, Weiss SE, Alexander BM, McCluskey CS, Gerard M, Smith KH, Jain RK, Batchelor TT, Ligon KL, Wen PY

A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients.
Clin Cancer Res. 2015;21(16):3610-8 - PMID: 25910950 - PMCID: PMC4790106 - DOI: 10.1158/1078-0432.CCR-14-3220

Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, Duda DG

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.
Hepatology. 2015;61(5):1591-602 - PMID: 25529917 - PMCID: PMC4406806 - DOI: 10.1002/hep.27665

Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG, Nocera DG

A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.
Chem Sci. 2012;3(10):2980-2985 - PMID: 26413260 - PMCID: PMC4582792 - DOI: 10.1039/C2SC20212C

Chung HW, Chung HJ

Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683-3688, 2000.
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Berlin K, Jain RK, Richert C

Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins.
Biotechnol Bioeng. 1998;61(2):107-18 - PMID: 10099504 - DOI: 10.1002/(sici)1097-0290(199821)61:2<107::aid-bit5>3.0.co;2-q

Jain RK, Janda KD, Saltzman WM

Drug discovery and delivery.
Mol Med Today. 1995;1(1):4 - PMID: 9415129 - DOI: 10.1016/1357-4310(95)80005-0

Kozin SV, Maimon N, Wang R, Gupta N, Munn L, Jain RK, Garkavtsev I

Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.
Oncotarget. 2017;8(65):108292-108302 - PMID: 29312532 - PMCID: PMC5752445 - DOI: 10.18632/oncotarget.22660

Andronesi OC, Esmaeili M, Borra RJH, Emblem K, Gerstner ER, Pinho MC, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Ivy SP, Wen PY, Duda DG, Jain R, Rosen BR, Sorensen GA, Batchelor TT

Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival.
NPJ Precis Oncol. 2017;1:ePub - PMID: 29202103 - PMCID: PMC5708878 - DOI: 10.1038/s41698-017-0020-3

Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE

Depolarization signatures map gold nanorods within biological tissue.
Nat Photonics. 2017;11:583-588 - PMID: 29201136 - PMCID: PMC5703429 - DOI: 10.1038/nphoton.2017.128

Gruionu G, Bazou D, Maimon N, Onita-Lenco M, Gruionu LG, Huang P, Munn LL

Implantable tissue isolation chambers for analyzing tumor dynamics in vivo.
Lab Chip. 2016;16(10):1840-51 - PMID: 27128791 - PMCID: PMC5155583 - DOI: 10.1039/c6lc00237d

Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK

Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27663981 - PMCID: PMC5131751 - DOI: 10.1101/cshperspect.a027094

Menter AR, Carroll NM, Sakoda LC, Delate T, Hornbrook MC, Jain RK, Kushi LH, Quinn VP, Ritzwoller DP

Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer.
Clin Lung Cancer. 2017;18(2):189-197.e3 - PMID: 27637408 - PMCID: PMC5424707 - DOI: 10.1016/j.cllc.2016.07.008
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