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Liu Z, Ma K, Jia Q, Yang Y, Fan P, Wang Y, Wang J, Sun J, Sun L, Shi H, Sun L, Zhu B, Xu W, Zhang L, Jain RK, Qin S, Huang Y
Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer
10.1136/bmjonc-2024-000473. 2024;3:e000473 - DOI: 10.1136/bmjonc-2024-000473
Dogra P, Shinglot V, Ruiz-Ramírez J, Cave J, Butner JD, Schiavone C, Duda DG, Kaseb AO, Chung C, Koay EJ, Cristini V, Ozpolat B, Calin GA, Wang Z
Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer.
Mol Cancer. 2024;23(1):156 - PMID: 39095771 - PMCID: PMC11295620 - DOI: 10.1186/s12943-024-02060-5
Datta M, Via LE, Dartois V, Xu L, Barry CE, Jain RK
Leveraging insights from cancer to improve tuberculosis therapy.
Trends Mol Med. 2024;:ePub - PMID: 39142973 - DOI: 10.1016/j.molmed.2024.07.011
Sivanand S, Gultekin Y, Winter PS, Vermeulen SY, Tchourine KM, Abbott KL, Danai LV, Gourgue F, Do BT, Crowder K, Kunchok T, Lau AN, Darnell AM, Jefferson A, Morita S, Duda DG, Aguirre AJ, Wolpin BM, Henning N, Spanoudaki V, Maiorino L, Irvine DJ, Yilmaz OH, Lewis CA, Vitkup D, Shalek AK, Vander Heiden MG
Cancer tissue of origin constrains the growth and metabolism of metastases.
Nat Metab. 2024;6(9):1668-1681 - PMID: 39160333 - PMCID: PMC11450831 - DOI: 10.1038/s42255-024-01105-9
Lei PJ, Fraser C, Jones D, Ubellacker JM, Padera TP
Lymphatic system regulation of anti-cancer immunity and metastasis.
Front Immunol. 2024;15:1449291 - PMID: 39211044 - PMCID: PMC11357954 - DOI: 10.3389/fimmu.2024.1449291
Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LK, Singh A, Fu J, Waterton SK, Cheng YC, Roberge S, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA
Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer.
bioRxiv. 2024;:ePub - PMID: 39257788 - PMCID: PMC11383995 - DOI: 10.1101/2024.08.28.609802
Mohamed YI, Lee SS, Demir T, Chamseddine S, Hu ZI, Xiao L, Elsayes K, Morris JS, Wolff RA, Hiatia R, Qayyum A, Rashid A, Duda DG, Yao JC, LaPelusa M, Koay EJ, Mahvash A, Al Azzam A, Dumbrava EE, Hassan M, Amin HM, Kaseb AO
Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab.
Cancer Biomark. 2024;41(1):83-91 - PMID: 39269823 - PMCID: PMC11491993 - DOI: 10.3233/CBM-230431
Ho AY, Shiao S, Kobald SA, Chen J, Duda DG, Ly A, Bossuyt V, Cho HL, Arnold B, Knott S, Gupta GP, McAndrew P, Karlan S, Tighiouart M, Muzikansky A, Basho R, McArthur H
PEARL: A Phase Ib/II Biomarker Study of Adding Radiation Therapy to Pembrolizumab Before Neoadjuvant Chemotherapy in Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer.
J Clin Oncol. 2024;:JCO2400003 - PMID: 39298718 - DOI: 10.1200/JCO.24.00003
Banerjee S, Booth CM, Bruera E, Büchler MW, Drilon A, Fry TJ, Ghobrial IM, Gianni L, Jain RK, Kroemer G, Llovet JM, Long GV, Pantel K, Pritchard-Jones K, Scher HI, Tabernero J, Weichselbaum RR, Weller M, Wu YL
Two decades of advances in clinical oncology - lessons learned and future directions.
Nat Rev Clin Oncol. 2024;21(11):771-780 - PMID: 39354161 - DOI: 10.1038/s41571-024-00945-4
Skelton WP, Masur J, Thomas J, Fallah P, Jain RK, Ravi P, Mantia C, McGregor BA, Nuzzo PV, Adib E, Zarif TE, Preston MA, Clinton TN, Li R, Steele GS, Kassouf W, Freeman D, Pond GR, Jain RK, Sonpavde GP
Impact of Angiotensin Converting Enzyme Inhibitors on Pathologic Complete Response With Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer.
Clin Genitourin Cancer. 2024;22(5):102143 - PMID: 39032202 - DOI: 10.1016/j.clgc.2024.102143
Sun Y, Yin Z, Li S, Wu L, Zhang Y, Zhao Y, Gomes Dos Santos IL, Subudhi S, Lei P, Muzikansky A, Yuan Z, Rueda BR, Jain RK, Xu L
Losartan rewires the tumor-immune microenvironment and suppresses IGF-1 to overcome resistance to chemo-immunotherapy in ovarian cancer.
Br J Cancer. 2024;:ePub - PMID: 39369055 - DOI: 10.1038/s41416-024-02863-9
Linke JA, Munn LL, Jain RK
Compressive stresses in cancer: characterization and implications for tumour progression and treatment.
Nat Rev Cancer. 2024;24(11):768-791 - PMID: 39390249 - DOI: 10.1038/s41568-024-00745-z
Park RJ, Parikh M, Pappas L, Sade-Feldman M, Kulkarni AS, Bi L, LaSalle TJ, Galway A, Kuhlman C, Blaszkowsky LS, Meyerhardt JA, Enzinger PC, Biller L, Allen JN, Kagey MH, Baum J, Sirard C, Duda DG, Zhu AX, Abrams TA, Hacohen N, Ting DT, Mehta A, Goyal L
Characterization of cell states in biliary tract cancers identifies mechanisms of therapeutic resistance in a phase II trial of DKN-01/nivolumab.
medRxiv. 2024;:ePub - PMID: 39417106 - PMCID: PMC11483019 - DOI: 10.1101/2024.10.08.24315092
Wu B, Tapadar S, Ruan Z, Sun CQ, Arnold RS, Johnston A, Olugbami JO, Arunsi U, Gaul DA, Petros JA, Kobayashi T, Duda DG, Oyelere AK
A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy.
ACS Pharmacol Transl Sci. 2024;7(10):3155-3169 - PMID: 39416967 - PMCID: PMC11475281 - DOI: 10.1021/acsptsci.4c00358
LaPelusa M, Chamseddine S, Tran Cao HS, Xiao L, Hasanov E, Bhosale P, Amin HM, Mohamed YI, Gok Yavuz B, Sakr Y, Xu L, Hu I, Lee SS, Sakamuri D, Jindal S, Nguyen V, Curran MA, Sun R, Rashid A, Duda DG, Sharma P, Qayyum A, Kaseb AO
Tissue and imaging biomarkers of response to neoadjuvant nivolumab or nivolumab plus ipilimumab in patients with resectable hepatocellular carcinoma.
Oncology. 2024;:1-20 - PMID: 39427654 - DOI: 10.1159/000541250
Kunz LV, Bosque JJ, Nikmaneshi M, Chamseddine I, Munn LL, Schuemann J, Paganetti H, Bertolet A
AMBER: A Modular Model for Tumor Growth, Vasculature and Radiation Response.
Bull Math Biol. 2024;86(12):139 - PMID: 39460828 - DOI: 10.1007/s11538-024-01371-4
Abbott KL, Subudhi S, Ferreira R, Gültekin Y, Steinbuch SC, Munim MB, Honeder SE, Kumar AS, Ramesh DL, Wu M, Hansen JA, Sivanand S, Riedmayr LM, Duquette M, Ali A, Henning N, Shevzov-Zebrun A, Gourgue F, Barbeau AM, Waite M, Kunchok T, Ferraro GB, Do BT, Spanoudaki V, Sánchez-Rivera FJ, Jin X, Church GM, Jain RK, Vander Heiden MG
Site of breast cancer metastasis is independent of single nutrient levels.
bioRxiv. 2024;:ePub - PMID: 39484531 - PMCID: PMC11527034 - DOI: 10.1101/2024.10.24.616714
Wu B, Tapadar S, Ruan Z, Sun CQ, Arnold RS, Olugbami JO, Johnston A, Arunsi U, Gaul DA, Petros JA, Kobayashi T, Duda DG, Oyelere AK
A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy.
bioRxiv. 2024;:ePub - PMID: 38585757 - PMCID: PMC10996603 - DOI: 10.1101/2024.03.27.587062
Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin SM, Matsui A, Hernandez A, Pu Z, Halvorsen S, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Sassi S, Bardeesy N, Ho WJ, Jain RK, Duda DG
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
Cancer Immunol Res. 2024;12(4):400-412 - PMID: 38260999 - PMCID: PMC10985468 - DOI: 10.1158/2326-6066.CIR-23-0486
Datta M, Kennedy M, Siri S, Via LE, Baish JW, Xu L, Dartois V, Barry CE, Jain RK
Mathematical model of oxygen, nutrient, and drug transport in Tuberculosis Granulomas.
PLoS Comput Biol. 2024;20(2):e1011847 - PMID: 38335224 - PMCID: PMC10883541 - DOI: 10.1371/journal.pcbi.1011847
Wolf B, Jain RK
Unraveling a hidden player in lymphovascular invasion in bladder cancer.
Cancer Cell. 2024;42(4):509-512 - PMID: 38458186 - DOI: 10.1016/j.ccell.2024.02.007
Chamseddine S, LaPelusa M, Xiao L, Mohamed YI, Lee SS, Hu ZI, Hatia RI, Hassan M, Yao JC, Duda DG, Datar S, Amin HM, Kaseb AO
Plasma Growth Hormone as a Prognostic Biomarker to Durvalumab and Tremelimumab in Patients with Advanced Hepatocellular Carcinoma.
J Hepatocell Carcinoma. 2024;11:455-461 - PMID: 38463542 - PMCID: PMC10921889 - DOI: 10.2147/JHC.S452564
Gomes-Santos IL, Kumar AS, Hausmann F, Meyer MN, Shiferaw SZ, Amoozgar Z, Jain RK, Fukumura D
Exercise intensity governs tumor control in mice with breast cancer.
Front Immunol. 2024;15:1339232 - PMID: 38495879 - PMCID: PMC10940460 - DOI: 10.3389/fimmu.2024.1339232
Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Stylianopoulos T, Munn LL, Jain RK
In silico clinical studies for optimal COVID-19 vaccination schedules in patients with cancer.
Cell Rep Med. 2024;5(3):101436 - PMID: 38508146 - PMCID: PMC10982978 - DOI: 10.1016/j.xcrm.2024.101436
Datta M, Via LE, Dartois V, Weiner DM, Zimmerman M, Kaya F, Walker AM, Fleegle JD, Raplee ID, McNinch C, Zarodniuk M, Kamoun WS, Yue C, Kumar AS, Subudhi S, Xu L, Barry CE, Jain RK
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
Proc Natl Acad Sci U S A. 2024;121(14):e2321336121 - PMID: 38530888 - PMCID: PMC10998582 - DOI: 10.1073/pnas.2321336121
Dogra P, Shinglot V, Ruiz-Ramírez J, Cave J, Butner JD, Schiavone C, Duda DG, Kaseb AO, Chung C, Koay EJ, Cristini V, Ozpolat B, Calin GA, Wang Z
Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer.
medRxiv. 2024;:ePub - PMID: 38559070 - PMCID: PMC10980136 - DOI: 10.1101/2024.03.14.24304306
Saylor PJ, Kozin SV, Matsui A, Goldberg SI, Aoki S, Shigeta K, Mamessier E, Smith MR, Dror Michaelson M, Lee RJ, Duda DG
The radiopharmaceutical radium-223 has immunomodulatory effects in patients and facilitates anti-programmed death receptor-1 therapy in murine models of bone metastatic prostate cancer.
Radiother Oncol. 2024;192:110091 - PMID: 38224917 - PMCID: PMC10905770 - DOI: 10.1016/j.radonc.2024.110091
Gruionu G, Baish J, McMahon S, Blauvelt D, Gruionu LG, Lenco MO, Vakoc BJ, Padera TP, Munn LL
Experimental and theoretical model of microvascular network remodeling and blood flow redistribution following minimally invasive microvessel laser ablation.
Sci Rep. 2024;14(1):8767 - PMID: 38627467 - PMCID: PMC11021487 - DOI: 10.1038/s41598-024-59296-w
Razavi MS, Munn LL, Padera TP
Mechanics of Lymphatic Pumping and Lymphatic Function.
Cold Spring Harb Perspect Med. 2024;:ePub - PMID: 38692743 - DOI: 10.1101/cshperspect.a041171
Razavi MS, Ruscic KJ, Korn EG, Marquez M, Houle TT, Singhal D, Munn LL, Padera TP
A Multiresolution Approach with Method-Informed Statistical Analysis for Quantifying Lymphatic Pumping Dynamics.
bioRxiv. 2024;:ePub - PMID: 38712181 - PMCID: PMC11071510 - DOI: 10.1101/2024.04.24.590950
Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell J, Vander Heiden MG
Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
Elife. 2024;13:ePub - PMID: 38787918 - PMCID: PMC11126308 - DOI: 10.7554/eLife.95652
Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Munn LL, Jain RK, Stylianopoulos T
Dynamic heterogeneity in COVID-19: Insights from a mathematical model.
PLoS One. 2024;19(5):e0301780 - PMID: 38820409 - PMCID: PMC11142552 - DOI: 10.1371/journal.pone.0301780
Li H, Zhang J, Padera TP, Baish JW, Munn LL
Fluid dynamics and leukocyte transit in the lymphatic system.
PNAS Nexus. 2024;3(6):pgae195 - PMID: 38827815 - PMCID: PMC11141778 - DOI: 10.1093/pnasnexus/pgae195
Lu S, Yin Z, Chen J, Wu L, Sun Y, Gao X, Huang P, Jordan JT, Plotkin SR, Xu L
Integrating Ataxia Evaluation into Tumor-Induced Hearing Loss Model to Comprehensively Study NF2-Related Schwannomatosis.
Cancers (Basel). 2024;16(11):ePub - PMID: 38893082 - PMCID: PMC11171041 - DOI: 10.3390/cancers16111961
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