Huang Lab
Morita S, Lei PJ, Shigeta K, Ando T, Kobayashi T, Kikuchi H, Matsui A, Huang P, Pittet MJ, Duda DG
Combination CXCR4 and PD1 blockade enhances intratumoral dendritic cell activation and immune responses against hepatocellular carcinoma.
Cancer Immunol Res. 2024;:ePub - PMID: 39514263 - DOI: 10.1158/2326-6066.CIR-24-0324
Lu S, Yin Z, Chen J, Wu L, Sun Y, Gao X, Huang P, Jordan JT, Plotkin SR, Xu L
Integrating Ataxia Evaluation into Tumor-Induced Hearing Loss Model to Comprehensively Study NF2-Related Schwannomatosis.
Cancers (Basel). 2024;16(11):ePub - PMID: 38893082 - PMCID: PMC11171041 - DOI: 10.3390/cancers16111961
Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin SM, Matsui A, Hernandez A, Pu Z, Halvorsen S, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Sassi S, Bardeesy N, Ho WJ, Jain RK, Duda DG
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
Cancer Immunol Res. 2024;12(4):400-412 - PMID: 38260999 - PMCID: PMC10985468 - DOI: 10.1158/2326-6066.CIR-23-0486
Jain R, Krishnan S, Lee S, Amoozgar Z, Subudhi S, Kumar A, Posada J, Lindeman N, Lei P, Duquette M, Roberge S, Huang P, Andersson P, Datta M, Munn L, Fukumura D
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma.
Res Sq. 2023;:ePub - PMID: 38234841 - PMCID: PMC10793505 - DOI: 10.21203/rs.3.rs-3707472/v1
Morita S, Kikuchi H, Birch G, Matsui A, Morita A, Kobayashi T, Ruan Z, Huang P, Hernandez A, Coyne EM, Shin SM, Yarchoan M, Mino-Kenudson M, Romee R, Ho WJ, Duda DG
Preventing NK cell activation in the damaged liver induced by cabozantinib/PD-1 blockade increases survival in hepatocellular carcinoma models.
bioRxiv. 2023;:ePub - PMID: 37961529 - PMCID: PMC10634718 - DOI: 10.1101/2023.10.20.563378
Lei PJ, Pereira ER, Andersson P, Amoozgar Z, Van Wijnbergen JW, O'Melia MJ, Zhou H, Chatterjee S, Ho WW, Posada JM, Kumar AS, Morita S, Menzel L, Chung C, Ergin I, Jones D, Huang P, Beyaz S, Padera TP
Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes.
J Exp Med. 2023;220(9):ePub - PMID: 37341991 - PMCID: PMC10286805 - DOI: 10.1084/jem.20221847
Jana S, Li W, Lei PJ, Wang Z, Huang P, Jones D
"Isolation and characterization of a novel hormone receptor positive mammary adenocarcinoma MCa-P1362 with stromal drivers of tumor growth, metastasis, and drug resistance".
bioRxiv. 2023;:ePub - PMID: 37333242 - PMCID: PMC10274631 - DOI: 10.1101/2023.06.02.543434
Zhang Q, Gerweck LE, Cascio E, Gu L, Yang Q, Dong X, Huang P, Bertolet A, Nesteruk KP, Sung W, McNamara AL, Schuemann J
Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine.
Cancers (Basel). 2023;15(8):ePub - PMID: 37190197 - PMCID: PMC10137009 - DOI: 10.3390/cancers15082269
Wang Y, Drum DL, Sun R, Zhang Y, Yu L, Jia L, Isakoff SJ, Kehlmann AM, Dal AE, Dotti G, Zheng H, Ferrone CR, Taghian AG, DeLeo AB, Zhang H, Jounaidi Y, Fan S, Huang P, Wang C, Yang J, Boland GM, Sadreyev RI, Wong L, Ferrone S, Wang X
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and tumor microenvironment, overcoming multiple obstacles of CAR T therapy for solid tumors.
Res Sq. 2023;:ePub - PMID: 36865255 - PMCID: PMC9980213 - DOI: 10.21203/rs.3.rs-2595410/v1
Gupta N, Ochiai H, Hoshino Y, Klein S, Zustin J, Ramjiawan RR, Kitahara S, Maimon N, Bazou D, Chiang S, Li S, Schanne DH, Jain RK, Munn LL, Huang P, Kozin SV, Duda DG
Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models.
Cancers (Basel). 2023;15(4):ePub - PMID: 36831366 - PMCID: PMC9954510 - DOI: 10.3390/cancers15041021
Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin S, Matsui A, Pu Z, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Bardeesy N, Ho WJ, Jain RK, Duda DG
Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
bioRxiv. 2023;:ePub - PMID: 36747853 - PMCID: PMC9901023 - DOI: 10.1101/2023.01.26.525680
Zhang Q, Gerweck LE, Cascio EW, Yang Q, Huang P, Niemierko A, Bertolet A, Nesteruk KP, McNamara AL, Schuemann J
Proton FLASH effects on mouse skin at different oxygen tensions.
Phys Med Biol. 2023;68(5):ePub - PMID: 36731139 - PMCID: PMC11164666 - DOI: 10.1088/1361-6560/acb888
Jones D, Wang Z, Chen I, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, Van Wijnbergen JW, Pereira E, Vakoc B, Huang P, Nia H, Padera T
Solid stress impairs lymphocyte infiltration into lymph node metastases.
FASEB J. 2022;36 Suppl 1:ePub - PMID: 35557097 - DOI: 10.1096/fasebj.2022.36.S1.R4616
Kikuchi H, Matsui A, Morita S, Amoozgar Z, Inoue K, Ruan Z, Staiculescu D, Wong JS, Huang P, Yau T, Jain RK, Duda DG
Increased CD8+ T-Cell Infiltration and Efficacy for Multikinase Inhibitors after PD-1 Blockade in Hepatocellular Carcinoma.
J Natl Cancer Inst. 2022;114(9):1301-1305 - PMID: 35288743 - PMCID: PMC9468280 - DOI: 10.1093/jnci/djac051
Moran H, Cancel LM, Huang P, Roberge S, Xu T, Tarbell JM, Munn LL
Glycocalyx mechanotransduction mechanisms are involved in renal cancer metastasis.
Matrix Biol Plus. 2022;13:100100 - PMID: 35106474 - PMCID: PMC8789524 - DOI: 10.1016/j.mbplus.2021.100100
Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118
Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP
Solid stress impairs lymphocyte infiltration into lymph-node metastases.
Nat Biomed Eng. 2021;5(12):1426-1436 - PMID: 34282290 - PMCID: PMC8678215 - DOI: 10.1038/s41551-021-00766-1
Amoozgar Z, Kloepper J, Ren J, Tay RE, Kazer SW, Kiner E, Krishnan S, Posada JM, Ghosh M, Mamessier E, Wong C, Ferraro GB, Batista A, Wang N, Badeaux M, Roberge S, Xu L, Huang P, Shalek AK, Fukumura D, Kim HJ, Jain RK
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Nat Commun. 2021;12(1):2582 - PMID: 33976133 - PMCID: PMC8113440 - DOI: 10.1038/s41467-021-22885-8
Li W, Li S, Chen IX, Liu Y, Ramjiawan RR, Leung CH, Gerweck LE, Fukumura D, Loeffler JS, Jain RK, Duda DG, Huang P
Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model.
Radiat Oncol. 2021;16(1):48 - PMID: 33663521 - PMCID: PMC7934382 - DOI: 10.1186/s13014-021-01775-9
Shigeta K, Matsui A, Kikuchi H, Klein S, Mamessier E, Chen IX, Aoki S, Kitahara S, Inoue K, Shigeta A, Hato T, Ramjiawan RR, Staiculescu D, Zopf D, Fiebig L, Hobbs GS, Quaas A, Dima S, Popescu I, Huang P, Munn LL, Cobbold M, Goyal L, Zhu AX, Jain RK, Duda DG
Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
J Immunother Cancer. 2020;8(2):ePub - PMID: 33234602 - PMCID: PMC7689089 - DOI: 10.1136/jitc-2020-001435
Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Proc Natl Acad Sci U S A. 2019;116(22):10674-10680 - PMID: 31040208 - PMCID: PMC6561160 - DOI: 10.1073/pnas.1819889116
Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
Nat Biomed Eng. 2019;3(3):230-245 - PMID: 30948807 - PMCID: PMC6452896 - DOI: 10.1038/s41551-018-0334-7
Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK
Quantifying solid stress and elastic energy from excised or in situ tumors.
Nat Protoc. 2018;13(5):1091-1105 - PMID: 29674756 - PMCID: PMC6546092 - DOI: 10.1038/nprot.2018.020
Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP
Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction.
Sci Transl Med. 2018;10(424):ePub - PMID: 29343625 - PMCID: PMC5953194 - DOI: 10.1126/scitranslmed.aam7964
Li W, Yang W, Liu Y, Chen S, Chin S, Qi X, Zhao Y, Liu H, Wang J, Mei X, Huang P, Xu D
MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.
Oncotarget. 2017;8(43):73938-73946 - PMID: 29088758 - PMCID: PMC5650313 - DOI: 10.18632/oncotarget.17881
Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J
Gut microbiota is critical for the induction of chemotherapy-induced pain.
Nat Neurosci. 2017;20(9):1213-1216 - PMID: 28714953 - PMCID: PMC5575957 - DOI: 10.1038/nn.4606
Li W, Yang W, Liu Y, Chen S, Chin S, Qi X, Zhao Y, Liu H, Wang J, Mei X, Huang P, Xu D
MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.
Oncotarget. 2017;:ePub - PMID: 28575858
Chen Y, Liu YC, Sung YC, Ramjiawan RR, Lin TT, Chang CC, Jeng KS, Chang CF, Liu CH, Gao DY, Hsu FF, Duyverman AM, Kitahara S, Huang P, Dima S, Popescu I, Flaherty KT, Zhu AX, Bardeesy N, Jain RK, Benes CH, Duda DG
Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors.
Sci Rep. 2017;7:44123 - PMID: 28276530 - PMCID: PMC5343435 - DOI: 10.1038/srep44123
Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, Duda DG
CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.
Hepatology. 2015;61(5):1591-602 - PMID: 25529917 - PMCID: PMC4406806 - DOI: 10.1002/hep.27665
Gao X, Zhao Y, Stemmer-Rachamimov AO, Liu H, Huang P, Chin S, Selig MK, Plotkin SR, Jain RK, Xu L
Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model.
Proc Natl Acad Sci U S A. 2015;112(47):14676-81 - PMID: 26554010 - PMCID: PMC4664377 - DOI: 10.1073/pnas.1512570112
Reiberger T, Chen Y, Ramjiawan RR, Hato T, Fan C, Samuel R, Roberge S, Huang P, Lauwers GY, Zhu AX, Bardeesy N, Jain RK, Duda DG
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Nat Protoc. 2015;10(8):1264-1274 - PMID: 26203823 - PMCID: PMC4800979 - DOI: 10.1038/nprot.2015.080
Zhang L, Li K, Sun R, Zhang Y, Ji J, Huang P, Yang H, Tian Y
Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study.
Radiat Oncol. 2014;9(1):281 - PMID: 25498371 - PMCID: PMC4271325 - DOI: 10.1186/s13014-014-0281-8
Li W, Huang P, Chen DJ, Gerweck LE
Determinates of tumor response to radiation: Tumor cells, tumor stroma and permanent local control.
Radiother Oncol. 2014;113(1):146-9 - PMID: 25284063 - PMCID: PMC4280081 - DOI: 10.1016/j.radonc.2014.09.006
Wang Y, Li W, Patel SS, Cong J, Zhang N, Sabbatino F, Liu X, Qi Y, Huang P, Lee H, Taghian A, Li JJ, DeLeo AB, Ferrone S, Epperly MW, Ferrone CR, Ly A, Brachtel EF, Wang X
Blocking the formation of radiation-induced breast cancer stem cells.
Oncotarget. 2014;5(11):3743-55 - PMID: 25003837 - PMCID: PMC4116517 - DOI: 10.18632/oncotarget.1992
Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Nat Commun. 2013;4:2516 - PMID: 24084631 - PMCID: PMC3806395 - DOI: 10.1038/ncomms3516
Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Proc Natl Acad Sci U S A. 2012;109(43):17561-6 - PMID: 23045683 - PMCID: PMC3491458 - DOI: 10.1073/pnas.1215397109
Wang E, Feng Y, Zhang M, Zou L, Li Y, Buys ES, Huang P, Brouckaert P, Chao W
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms.
Anesthesiology. 2011;114(3):603-13 - PMID: 21270629 - PMCID: PMC3044772 - DOI: 10.1097/ALN.0b013e31820a4d5b
Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L
PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
Clin Cancer Res. 2011;17(11):3638-48 - PMID: 21459800 - PMCID: PMC3107920 - DOI: 10.1158/1078-0432.CCR-10-2456
Huang P, Westmoreland SV, Jain RK, Fukumura D
Spontaneous nonthymic tumors in SCID mice.
Comp Med. 2011;61(3):227-34 - PMID: 21819692 - PMCID: PMC3123755
Huang P, Duda DG, Jain RK, Fukumura D
Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079
Kozin SV, Niemierko A, Huang P, Silva J, Doppke KP, Suit HD
Inter- and intramouse heterogeneity of radiation response for a growing paired organ.
Radiat Res. 2008;170(2):264-7 - PMID: 18666813 - DOI: 10.1667/RR1262.1
Huang P, McKee TD, Jain RK, Fukumura D
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comp Med. 2005;55(3):236-43 - PMID: 16089171
Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK
Differential transplantability of tumor-associated stromal cells.
Cancer Res. 2004;64(17):5920-4 - PMID: 15342367 - DOI: 10.1158/0008-5472.CAN-04-1268
Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD
Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Cancer Res. 2003;63(4):747-51 - PMID: 12591719
Huang P, Olive PL, Durand RE
Use of the comet assay for assessment of drug resistance and its modulation in vivo.
Br J Cancer. 1998;77(3):412-6 - PMID: 9472636 - PMCID: PMC2151301 - DOI: 10.1038/bjc.1998.65
Huang P, Taghian A, Allam A, Freeman J, Duffy M, Suit H
The effect of whole-body irradiation of nude mice on the tumor transplantability and control probability of a human soft tissue sarcoma xenograft.
Radiat Res. 1996;145(3):337-42 - PMID: 8927702
Huang P, Taghian A, Hsu DW, Perez LA, Allam A, Duffy M, DaCosta A, Suit HD
Spontaneous metastasis, proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenografts.
Radiother Oncol. 1996;41(1):73-81 - PMID: 8961371 - DOI: 10.1016/s0167-8140(96)91803-4
Huang P, Suit HD
Spontaneous osteosarcoma in a severe combined immunodeficient (SCID/Sed) mouse.
Contemp Top Lab Anim Sci. 1996;35(6):75-7 - PMID: 16450991
Huang P, Allam A, Taghian A, Ruka W, Freeman J, Duffy M, Suit HD
Quantitative comparison of xenotransplantation of a human soft tissue sarcoma into the subcutaneous tissue of normal, postincision, and postincision plus indomethacin-treated nude mice.
J Surg Oncol. 1995;58(4):257-62 - PMID: 7723370 - DOI: 10.1002/jso.2930580412
Huang P, Allam A, Perez LA, Taghian A, Freeman J, Suit HD
The effect of combining recombinant human tumor necrosis factor-alpha with local radiation on tumor control probability of a human glioblastoma multiforme xenograft in nude mice.
Int J Radiat Oncol Biol Phys. 1995;32(1):93-8 - PMID: 7721643 - DOI: 10.1016/0360-3016(94)00492-4
Allam A, Perez LA, Huang P, Taghian A, Azinovic I, Freeman J, Duffy M, Efird J, Suit HD
The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice.
Int J Radiat Oncol Biol Phys. 1995;32(1):105-11 - PMID: 7721606 - DOI: 10.1016/0360-3016(95)00511-V
Huang P, Allam A, Taghian A, Freeman J, Duffy M, Suit HD
Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice.
J Neurosurg. 1995;83(2):308-15 - PMID: 7616277 - DOI: 10.3171/jns.1995.83.2.0308
Huang P
[Xenograft of human nasopharyngeal mucosa in nude mice].
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1991;24(4):219-20, 255 - PMID: 2486076
Huang P
[Adult nasopharyngeal mucosa xenograft and dinitrosopiperazine carcinogenesis in nude mice].
Zhonghua Yi Xue Za Zhi. 1991;71(8):441-3, 32 - PMID: 1660764
Guan EN, Zhou TC, Wang JH, Chen Y, Sun YX, Huang PG, Tang WP, Zhao ML
Effects of monoclonal antibody anti-EGF receptor on human nasopharyngeal carcinoma cell and other tumor cells.
Sci China B. 1990;33(11):1334-40 - PMID: 2095159
Guan E, Zhou TC, Wang JH, Huang PG, Tang WP, Zhao ML, Chen Y, Sun YX
Growth inhibition of human nasopharyngeal carcinoma in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies.
Int J Cell Cloning. 1989;7(4):242-56 - PMID: 2768842 - DOI: 10.1002/stem.5530070406
Tang WP, Huang PG, Zhao ML, Liao SL, Zeng Y
Wikstroemia indica promotes development of nasopharyngeal carcinoma in rats initiated by dinitrosopiperazine.
J Cancer Res Clin Oncol. 1988;114(4):429-31 - PMID: 3410882 - DOI: 10.1007/BF02128191
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