Padera Lab

Liao S, Padera TP

Lymphatic Function and Immune Regulation in Health and Disease.
Lymphat Res Biol. 2013;11(3):136-43 - PMID: 24024577 - PMCID: PMC3780287 - DOI: 10.1089/lrb.2013.0012

Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164

Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK

Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment.
Intravital. 2012;1(1):ePub - PMID: 24353926 - PMCID: PMC3864876 - DOI: 10.4161/intv.21557

Kesler CT, Liao S, Munn LL, Padera TP

Lymphatic vessels in health and disease.
Wiley Interdiscip Rev Syst Biol Med. 2012;5(1):111-24 - PMID: 23209022 - PMCID: PMC3527689 - DOI: 10.1002/wsbm.1201

Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP

Impaired lymphatic contraction associated with immunosuppression.
Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108

Liao S, Padera TP, Jain RK

Notch leads lymphatics and links them to blood vessels.
Arterioscler Thromb Vasc Biol. 2010;30(9):1682-3 - PMID: 20720193 - PMCID: PMC2945915 - DOI: 10.1161/ATVBAHA.110.210633

Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH

Lymphotoxin-alpha contributes to lymphangiogenesis.
Blood. 2010;116(12):2173-82 - PMID: 20566898 - PMCID: PMC2951858 - DOI: 10.1182/blood-2009-12-256065

Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D

Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
Cancer Res. 2009;69(7):2801-8 - PMID: 19318557 - PMCID: PMC2670480 - DOI: 10.1158/0008-5472.CAN-08-4051

Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK

Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Biophys J. 2009;97(1):330-6 - PMID: 19580771 - PMCID: PMC2711376 - DOI: 10.1016/j.bpj.2009.03.064

Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971

Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK

Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
J Cell Physiol. 2009;219(2):430-7 - PMID: 19170073 - PMCID: PMC2665001 - DOI: 10.1002/jcp.21686

Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E

Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
N Engl J Med. 2009;361(4):358-67 - PMID: 19587327 - PMCID: PMC4816642 - DOI: 10.1056/NEJMoa0902579

Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nat Methods. 2009;6(2):143-5 - PMID: 19151720 - PMCID: PMC2877598 - DOI: 10.1038/nmeth.1295

Jain RK, Booth MF, Padera TP, Munn LL, Fukumura D, Brown E

Applications of nonlinear intravital microscopy in tumor biology.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 29:735-756

Padera TP, Jain RK

VEGFR3: a new target for antiangiogenesis therapy?
Dev Cell. 2008;15(2):178-9 - PMID: 18694556 - PMCID: PMC4790102 - DOI: 10.1016/j.devcel.2008.07.014

Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182

Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Data do not support benefits of anti-VEGFR3 therapy
Cancer Research. 2007;67:5055

Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK

Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938 - DOI: 10.1593/neo.07643

Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Anti-VEGFR-3 therapy and lymph node metastasis [corrected].
Cancer Res. 2007;67(10):5055; author reply 5056 - PMID: 17510438 - DOI: 10.1158/0008-5472.CAN-06-2935

Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK

Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer Res. 2006;66(7):3360-4 - PMID: 16585153 - DOI: 10.1158/0008-5472.CAN-05-2655

Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, Delaney TF, Gaissert HA, Pearce J, Rosenberg AE, Jain RK, Ebb DH

Platelet-derived growth factor receptor-beta in Gorham's disease.
Nat Clin Pract Oncol. 2006;3(12):693-7 - PMID: 17139320 - PMCID: PMC2693369 - DOI: 10.1038/ncponc0660

Hoon DS, Kitago M, Kim J, Mori T, Piris A, Szyfelbein K, Mihm MC, Nathanson SD, Padera TP, Chambers AF, Vantyghem SA, MacDonald IC, Shivers SC, Alsarraj M, Reintgen DS, Passlick B, Sienel W, Pantel K

Molecular mechanisms of metastasis.
Cancer Metastasis Rev. 2006;25(2):203-20 - PMID: 16770533 - DOI: 10.1007/s10555-006-8500-x

Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK

Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Cancer Res. 2006;66(16):8065-75 - PMID: 16912183 - DOI: 10.1158/0008-5472.CAN-06-1392

Hagendoorn J, Padera TP, Fukumura D, Jain RK

Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Trends Cardiovasc Med. 2005;15(5):169-73 - PMID: 16165013 - DOI: 10.1016/j.tcm.2005.06.003

Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK

Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Cancer Res. 2004;64(13):4400-4 - PMID: 15231646 - DOI: 10.1158/0008-5472.CAN-04-0752

Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK

Pathology: cancer cells compress intratumour vessels.
Nature. 2004;427(6976):695 - PMID: 14973470 - DOI: 10.1038/427695a

Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK

Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.
Circ Res. 2004;95(2):204-9 - PMID: 15192027 - DOI: 10.1161/01.RES.0000135549.72828.24

Padera TP, Stoll BR, So PT, Jain RK

Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.
Mol Imaging. 2003;1(1):9-15 - PMID: 12920856 - DOI: 10.1162/15353500200200004

Padera TP, Boucher Y, Jain RK

Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Cancer Res. 2003;63(23):8555-6; author reply 8558 - PMID: 14679026

Jain RK, Padera TP

Development. Lymphatics make the break.
Science. 2003;299(5604):209-10 - PMID: 12522236 - DOI: 10.1126/science.1081345

Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK

Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science. 2002;296(5574):1883-6 - PMID: 11976409 - DOI: 10.1126/science.1071420

Jain RK, Padera TP

Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy.
J Natl Cancer Inst. 2002;94(11):785-7 - PMID: 12048260 - DOI: 10.1093/jnci/94.11.785

Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK

Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer Res. 2001;61(6):2404-8 - PMID: 11289105

Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK

LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer Res. 2001;61(22):8079-84 - PMID: 11719431

Ramanujan S, Koenig GC, Padera TP, Stoll BR, Jain RK

Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
Cancer Res. 2000;60(5):1442-8 - PMID: 10728711

Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK

Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Cancer Res. 2000;60(16):4556-60 - PMID: 10969807
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