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Barack Obama To Present National Medal Of Science To Professor Rakesh K. Jain
Dr. Jain will be receiving the enormously prestigious National Medal of Science from President Obama early next year in a ceremony at the White House. Dr. Jain is among 9 esteemed recipients of this award; 8 additional awards will be presented for the National Medal of Technology and Innovation. Click here for the official press release from the White House.
Combining antiangiogenesis with radiation therapy may improve treatment of NF2-associated tumors
Researchers from the Steele Lab in collaboration with other MGH investigators recently published in the Proceedings of the National Academy of Sciences that treatment with an antibody blocking the angiogenic factor VEGF improves neurologic function in an NF2 mouse model by alleviating tissue edema, which may further improve neurologic function by decreasing muscle atrophy and increasing nerve regeneration. Furthermore, combining anti-VEGF with radiation therapy allows use of a lower radiation dose, which can achieve better tumor control and minimize radiation-related neurological damage. See press releases from MGH and MedicalResearch.
Dr. Jain awarded Outstanding Investigator Award
Dr. Jain has been awarded the highly prestigious NCI Outstanding Investigator Award, a seven year award that supports innovative research by established leaders in cancer research. Check out all the 2015 awardees, including Dr. Jain, here.
Antiangiogenic treatment primarily benefits breast cancer patients with well-perfused tumors
Researchers from the Steele Lab in collaboration with investigators at the Dana Farber Cancer Institute recently published in the Proceedings of the National Academy of Sciences that preoperative treatment with bevacizumab, an antiangiogenic drug, primarily benefitted breast cancer patients with highly perfused tumors. This may, in part, explain why antiangiogenesis treatment fails to benefit some breast cancer patients. See the press release from MGH and Targeted Oncology.
Giorgio Seano wins 5th place in 2015 Nikon Small World photo competition
Check out the 5th place winner of this year's Nikon Small World photo, by postdoctoral fellow Giorgio Seano, of glioblastoma in a mouse brain featured on CNN, TIME, CBSNews, and The Huffington Post.
Nova Next Interview with Dr. Jain and Collaborator Dr. Clif Barry on Tuberculosis
Read about adapting tumor-fighting strategies to combat tuberculosis here.
Development of new blood vessels not essential to growth of lymph node metastases
Dr. Padera's research group recently published in Journal of the National Cancer Institute that the growth of metastases in lymph nodes does not require new blood vessels but instead takes advantage of existing blood vessels. This may, in part, explain why antiangiogenesis therapies have been largely ineffective in preventing new metastases. See the press release here.
Dr. Jain receives Honorary Degree from Duke University
Dr. Jain was among six distinguished recipients who received an honorary degree from Duke University at the university commencement on May 10, 2015. A press release detailing the honorary degree awardees can be found here. Duke University President, Richard Brodhead, introduces the awardees at 1hr49min here.
Dr. Jain receives honorary degree from Duke University
Dr. Jain was one of six distinguished recipients who received honorary degrees from Duke University at this year's commencement on May 10. See the press release here and an introduction to the recipients by the university President, Richard Brodhead, at 1 hr 49 min in to the commencement ceremony here.
Dr. Dai Fukumura receives MCS Landis Award
Dr. Dai Fukumura, Associate Professor of Radiation Oncology in the Edwin L. Steele Laboratories, was awarded the Eugene M. Landis Research Award from the Microcirculatory Society. This annual award recognizes one outstanding investigator who has made significant contributions to the field of microcirculation. Dr. Fukumura gave an award lecture on March 28, 2015 at the Microcirculatory Society Annual Meeting in Boston.
Gino Ferraro receives Susan G. Komen fellowship
Gino Ferraro, Ph.D., a post-doctoral fellow in the Edwin L. Steele Laboratories, has been awarded a three-year fellowship by the Susan G. Komen foundation for his research in breast cancer brain metastasis. Gino Ferraro is the second fellow from the Steele Labs to recently receive this prestigious award; it was previously awarded to Giorgio Seano, Ph.D., in 2014.
Steele Labs members win SAC Posters of Distinction
At the 68th Annual Meeting of the MGH Scientific Advisory Committee (SAC) on April 1-2, 2015, sponsored by the Executive Committee on Research (ECOR), two members from the Edwin L. Steele Laboratories won awards for Posters of Distinction: Giorgio Seano, Ph.D., a post-doctoral fellow, and Meenal Datta, M.S., a graduate student.
Rakesh Jain receives Honorary Degree
Dr. Rakesh Jain, director of the Steele Laboratories, recently received the degree of Doctor of Science (Honoris Causa), the highest academic degree offered, from his alma mater: the Indian Institute of Technology Kanpur. Dr. Jain received his Bachelor of Technology degree from IIT-Kanpur in Chemical Engineering in 1972.

Medical Research Interview with Dr. Jain
Read an interview about vascular normalization in tuberculosis granulomas here.
Honorary doctorate from KU Leuven to Dr. Jain
Read here about the upcoming Patron Saint's Day celebration, in which an honorary doctorate will be conferred to Dr. Jain! Information about the lecture he will give on the occasion can be found here. Some beautiful pictures of the ceremony are here. See Dr. Jain's introduction by Dr. Peter Carmeliet here and Dr. Jain's acceptance speech here
Dr. Jain is named an AAAS Fellow
Rakesh Jain, PhD, director of the Steele Laboratory in the MGH Department of Radiation Oncology, Jay Loeffler, MD, chief of the Department of Radiation Oncology, and Jules Dienstag, MD, a physician in the MGH Gastrointestinal Unit, have been selected as 2014 American Association for the Advancement of Science (AAAS) Fellows, honoring them for the contributions to innovation, education and scientific leadership. The tradition of electing AAAS Fellows began in 1874 to recognize members for their scientifically or socially distinguished efforts to advance science or its applications. The honorees will be celebrated at the 2015 AAAS Annual Meeting in February. More details can be found here.
Antiangiogenesis drugs could make major improvement in tuberculosis treatment
Use of the same antiangiogenesis drugs that have improved treatment of some cancers could also help surmount persistent difficulties in treating tuberculosis (TB). In their PNAS Early Edition report, investigators from Massachusetts General Hospital (MGH) and the National Institute of Allergy and Infectious Disease (NIAID) show that blood vessels supplying pulmonary granulomas – dense masses of immune cells that surround pockets of the TB bacteria in the lungs of infected patients – have the same sort of structural and functional abnormalities seen in solid tumors and that treatment with the antiangiogenesis drug bevacizumab (Avastin) significantly improved delivery of a small-molecule drug surrogate within granulomas in an animal model. Read more here and here.
Protein identified by Mass. General team may protect tumor-initiating cells in breast cancer