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Nikmaneshi MR, Firoozabadi B, Mozafari A, Munn LL
A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth.
Sci Rep. 2020;10(1):3025 - PMID: 32080250 - DOI: 10.1038/s41598-020-59658-0
Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M
Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
Nat Biotechnol. 2020;:ePub - PMID: 32042168 - DOI: 10.1038/s41587-019-0404-8
Martin JD, Cabral H, Stylianopoulos T, Jain RK
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges.
Nat Rev Clin Oncol. 2020;17(4):251-266 - PMID: 32034288 - DOI: 10.1038/s41571-019-0308-z
Chen J, Duda DG
Overcoming sorafenib treatment-resistance in hepatocellular carcinoma: A future perspective at a time of rapidly changing treatment paradigms.
EBioMedicine. 2020;52:102644 - PMID: 32014823 - DOI: 10.1016/j.ebiom.2020.102644
Mpekris F, Voutouri C, Baish JW, Duda DG, Munn LL, Stylianopoulos T, Jain RK
Combining microenvironment normalization strategies to improve cancer immunotherapy.
Proc Natl Acad Sci U S A. 2020;117(7):3728-3737 - PMID: 32015113 - DOI: 10.1073/pnas.1919764117
Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z
A framework for advancing our understanding of cancer-associated fibroblasts.
Nat Rev Cancer. 2020;20(3):174-186 - PMID: 31980749 - DOI: 10.1038/s41568-019-0238-1
Flores-Toro JA, Luo D, Gopinath A, Sarkisian MR, Campbell JJ, Charo IF, Singh R, Schall TJ, Datta M, Jain RK, Mitchell DA, Harrison JK
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Proc Natl Acad Sci U S A. 2020;117(2):1129-1138 - PMID: 31879345 - DOI: 10.1073/pnas.1910856117
Seano G, Jain RK
Vessel co-option in glioblastoma: emerging insights and opportunities.
Angiogenesis. 2020;23(1):9-16 - PMID: 31679081 - DOI: 10.1007/s10456-019-09691-z
Arvanitis CD, Ferraro GB, Jain RK
The blood-brain barrier and blood-tumour barrier in brain tumours and metastases.
Nat Rev Cancer. 2020;20(1):26-41 - PMID: 31601988 - DOI: 10.1038/s41568-019-0205-x
Gerstner E, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T
Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma.
Clin Cancer Res. 2020;26(1):206-212 - PMID: 31558474 - DOI: 10.1158/1078-0432.CCR-19-1739
Leone JP, Duda DG, Hu J, Barry WT, Trippa L, Gerstner ER, Jain RK, Tan S, Lawler E, Winer EP, Lin NU, Tolaney SM
A phase II study of cabozantinib alone or in combination with trastuzumab in breast cancer patients with brain metastases.
Breast Cancer Res Treat. 2020;179(1):113-123 - PMID: 31541381 - DOI: 10.1007/s10549-019-05445-z
Kong N, Tao W, Ling X, Wang J, Xiao Y, Shi S, Ji X, Shajii A, Gan ST, Kim NY, Duda DG, Xie T, Farokhzad OC, Shi J
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes <i>p53</i>-deficient cancers to mTOR inhibition.
Sci Transl Med. 2019;11(523):ePub - PMID: 31852795 - DOI: 10.1126/scitranslmed.aaw1565
Tamburini BAJ, Padera TP, Lund AW
Editorial: Regulation of Immune Function by the Lymphatic Vasculature.
Front Immunol. 2019;10:2597 - PMID: 31781105 - PMCID: PMC6856668 - DOI: 10.3389/fimmu.2019.02597
Granoff MD, Johnson AR, Lee BT, Padera TP, Bouta EM, Singhal D
A Novel Approach to Quantifying Lymphatic Contractility during Indocyanine Green Lymphangiography.
Plast Reconstr Surg. 2019;144(5):1197-1201 - PMID: 31688768 - DOI: 10.1097/PRS.0000000000006176
Plotkin SR, Duda DG, Muzikansky A, Allen J, Blakeley J, Rosser T, Campian JL, Clapp DW, Fisher MJ, Tonsgard J, Ullrich N, Thomas C, Cutter G, Korf B, Packer R, Karajannis MA
Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannoma.
J Clin Oncol. 2019;:JCO1901367 - PMID: 31626572 - DOI: 10.1200/JCO.19.01367
Munn LL, Nia HT
Mechanosensing tensile solid stresses.
Proc Natl Acad Sci U S A. 2019;116(44):21960-21962 - PMID: 31619566 - DOI: 10.1073/pnas.1916115116
Fernández-Martos C, Pericay C, Losa F, García-Carbonero R, Layos L, Rodríguez-Salas N, Martin-Richard M, Alonso-Orduña V, Vera R, Gallego J, Capdevila J, Salud A, Nogué M, Maurel J, Guash I, Montagut C, Lopez C, Macias I, Jain RK, Garcia-Albeniz X
Effect of Aflibercept Plus Modified FOLFOX6 Induction Chemotherapy Before Standard Chemoradiotherapy and Surgery in Patients With High-Risk Rectal Adenocarcinoma: The GEMCAD 1402 Randomized Clinical Trial.
JAMA Oncol. 2019;:ePub - PMID: 31465088 - DOI: 10.1001/jamaoncol.2019.2294
Lee EQ, Muzikansky A, Duda DG, Gaffey S, Dietrich J, Nayak L, Chukwueke UN, Beroukhim R, Doherty L, Laub CK, LaFrankie D, Fontana B, Stefanik J, Ruland S, Caruso V, Bruno J, Ligon K, Reardon DA, Wen PY
Phase II trial of ponatinib in patients with bevacizumab-refractory glioblastoma.
Cancer Med. 2019;8(13):5988-5994 - PMID: 31444999 - DOI: 10.1002/cam4.2505
Shvedova M, Litvak MM, Roberts JD, Fukumura D, Suzuki T, Şencan İ, Li G, Reventun P, Buys ES, Kim HH, Sakadžić S, Ayata C, Huang PL, Feil R, Atochin DN
cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice.
J Cereb Blood Flow Metab. 2019;:271678X19870583 - PMID: 31423931 - DOI: 10.1177/0271678X19870583
Munn LL, Jain RK
Vascular regulation of antitumor immunity.
Science. 2019;365(6453):544-545 - PMID: 31395771 - DOI: 10.1126/science.aaw7875
Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Cobbold M, Zhu AX, Jain RK, Duda DG
Dual PD-1 and VEGFR-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC.
Hepatology. 2019;:ePub - PMID: 31378984 - DOI: 10.1002/hep.30889
Richter C, Andronesi OC, Borra RJH, Voigt F, Löck S, Duda DG, Guimaraes AR, Hong TS, Bortfeld TR, Seco J
Inter-patient variations of radiation-induced normal-tissue changes in Gd-EOB-DTPA-enhanced hepatic MRI scans during fractionated proton therapy.
Clin Transl Radiat Oncol. 2019;18:113-119 - PMID: 31341986 - PMCID: PMC6630151 - DOI: 10.1016/j.ctro.2019.04.013
Li H, Mei Y, Maimon N, Padera TP, Baish JW, Munn LL
The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations.
Sci Rep. 2019;9(1):10649 - PMID: 31337769 - DOI: 10.1038/s41598-019-46669-9
Saftoiu A, Bhutani MS, Itoi T, Arcidiacono PG, Bories E, Cazacu IM, Constantin A, Coronel E, Dietrich CF, Duda DG, Garcia JI, Hocke M, Ignee A, Jenssen C, Jinga M, Khor C, Oppong KW, Pereira S, Petrone MC, Santo E, Seicean A, Seo DW, Siyu S, Vilmann P, Waxman I, Yeaton P
Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol.
Endosc Ultrasound. 2019;8(4):235-240 - PMID: 31249159 - DOI: 10.4103/eus.eus_16_19
Moran H, Cancel LM, Mayer MA, Qazi H, Munn LL, Tarbell JM
The cancer cell glycocalyx proteoglycan glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis.
Biorheology. 2019;56(2-3):151-161 - PMID: 31256115 - DOI: 10.3233/BIR-180203
Ly KI, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER
Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.
Sci Rep. 2019;9(1):8721 - PMID: 31197238 - DOI: 10.1038/s41598-019-44365-2
Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, Allen JN, Corcoran RB, Ting DT, Faris JE, Zhu AX, Goyal L, Berger DL, Qadan M, Lillemoe KD, Talele N, Jain RK, DeLaney TF, Duda DG, Boucher Y, Fernández-Del Castillo C, Hong TS
Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.
JAMA Oncol. 2019;5(7):1020-1027 - PMID: 31145418 - DOI: 10.1001/jamaoncol.2019.0892
Datta M, Coussens LM, Nishikawa H, Hodi FS, Jain RK
Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies.
Am Soc Clin Oncol Educ Book. 2019;(39):165-174 - PMID: 31099649 - DOI: 10.1200/EDBK_237987
Amoozgar Z, Jain RK, Duda DG
Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?
Cancer Res. 2019;79(9):2104-2106 - PMID: 31043429 - DOI: 10.1158/0008-5472.CAN-19-0749
Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Proc Natl Acad Sci U S A. 2019;116(22):10674-10680 - PMID: 31040208 - DOI: 10.1073/pnas.1819889116
Ruscic KJ, Padera TP
Silence of the Lymphs: Some anaesthetic regimens inhibit lymphatic pumping.
J Physiol. 2019;597(11):2827-2828 - PMID: 31032908 - DOI: 10.1113/JP277914
Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
Nat Biomed Eng. 2019;3(3):230-245 - PMID: 30948807 - DOI: 10.1038/s41551-018-0334-7
Cleary JM, Horick NK, McCleary NJ, Abrams TA, Yurgelun MB, Azzoli CG, Rubinson DA, Brooks GA, Chan JA, Blaszkowsky LS, Clark JW, Goyal L, Meyerhardt JA, Ng K, Schrag D, Savarese DMF, Graham C, Fitzpatrick B, Gibb KA, Boucher Y, Duda DG, Jain RK, Fuchs CS, Enzinger PC
FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial.
Cancer. 2019;125(13):2213-2221 - PMID: 30913304 - DOI: 10.1002/cncr.32029
Johnson AR, Granoff MD, Lee BT, Padera TP, Bouta EM, Singhal D
The Impact of Taxane-based Chemotherapy on the Lymphatic System.
Ann Plast Surg. 2019;82(4S Suppl 3):S173-S178 - PMID: 30855384 - DOI: 10.1097/SAP.0000000000001884
Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N
Retraction Note: A homing system targets therapeutic T cells to brain cancer.
Nature. 2019;567(7746):132 - PMID: 30787441 - DOI: 10.1038/s41586-019-0967-z
Martin JD, Seano G, Jain RK
Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges.
Annu Rev Physiol. 2019;81:505-534 - PMID: 30742782 - DOI: 10.1146/annurev-physiol-020518-114700
Voutouri C, Kirkpatrick ND, Chung E, Mpekris F, Baish JW, Munn LL, Fukumura D, Stylianopoulos T, Jain RK
Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.
Proc Natl Acad Sci U S A. 2019;116(7):2662-2671 - PMID: 30700544 - DOI: 10.1073/pnas.1818322116
Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK
Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.
Proc Natl Acad Sci U S A. 2019;116(10):4558-4566 - PMID: 30700545 - DOI: 10.1073/pnas.1815515116
Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C, Cassará A, Guichard A, Iruela-Arispe ML, Lewis CE, Coussens LM, Bardia A, Jain RK, Pollard JW, De Palma M
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.
Nat Cell Biol. 2019;21(2):190-202 - PMID: 30598531 - DOI: 10.1038/s41556-018-0256-3
Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L
A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.
Nat Protoc. 2019;14(2):541-555 - PMID: 30617350 - DOI: 10.1038/s41596-018-0105-7
Nia HT, Munn LL, Jain RK
Mapping physical tumor microenvironment and drug delivery.
Clin Cancer Res. 2019;25(7):2024-2026 - PMID: 30630829 - DOI: 10.1158/1078-0432.CCR-18-3724
Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L
Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2019;116(6):2210-2219 - PMID: 30659155 - DOI: 10.1073/pnas.1818357116
Askoxylakis V, Ferraro GB, Badeaux M, Kodack DP, Kirst I, Shankaraiah RC, Wong CSF, Duda DG, Fukumura D, Jain RK
Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer.
NPJ Breast Cancer. 2019;5:4 - PMID: 30675514 - PMCID: PMC6333771 - DOI: 10.1038/s41523-018-0100-8
Liao S, Bouta EM, Morris LM, Jones D, Jain RK, Padera TP
Inducible Nitric Oxide Synthase and CD11b<sup>+</sup>Gr1<sup>+</sup> Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels.
Lymphat Res Biol. 2019;17(3):294-300 - PMID: 30358484 - DOI: 10.1089/lrb.2018.0013
Goyal L, Zheng H, Abrams TA, Miksad R, Bullock AJ, Allen JN, Yurgelun MB, Clark JW, Kambadakone A, Muzikansky A, Knowles M, Galway A, Afflitto AJ, DiNicola CF, Regan E, Hato T, Mamessier E, Shigeta K, Jain RK, Duda DG, Zhu AX
A Phase II and Biomarker Study of Sorafenib Combined with FOLFOX in Patients with Advanced Hepatocellular Carcinoma (HCC).
Clin Cancer Res. 2019;25(1):80-89 - PMID: 30190369 - DOI: 10.1158/1078-0432.CCR-18-0847
Khandekar MJ, Jain R
Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study.
Transl Cancer Res. 2018;7(Suppl 1):S16-S20 - PMID: 30175050 - PMCID: PMC6117158
Ina Ly K, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER
Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.
Sci Rep. 2018;8(1):17062 - PMID: 30459364 - PMCID: PMC6244161 - DOI: 10.1038/s41598-018-34820-x
Hong TS, Grassberger C, Yeap BY, Jiang W, Wo JY, Goyal L, Clark JW, Crane CH, Koay EJ, Dima S, Eyler CE, Popescu I, DeLaney TF, Zhu AX, Duda DG
Pretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy.
NPJ Precis Oncol. 2018;2:22 - PMID: 30374460 - PMCID: PMC6194077 - DOI: 10.1038/s41698-018-0065-y
Mitchell MJ, Jain RK, Langer R
Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities.
Nat Rev Cancer. 2018;18(11):720 - PMID: 30337715 - DOI: 10.1038/s41568-018-0072-x
Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N
A homing system targets therapeutic T cells to brain cancer.
Nature. 2018;561(7723):331-337 - PMID: 30185905 - DOI: 10.1038/s41586-018-0499-y
Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK
Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
Proc Natl Acad Sci U S A. 2018;115(37):E8717-E8726 - PMID: 30150398 - PMCID: PMC6140479 - DOI: 10.1073/pnas.1807105115
Lee EQ, Duda DG, Muzikansky A, Gerstner E, Kuhn JG, Reardon DA, Nayak L, Norden AD, Doherty L, LaFrankie D, Stefanik J, Vardam T, Smith KH, McCluskey C, Gaffey SC, Batchelor T, Jain RK, Wen PY
Phase I and biomarker study of plerixafor and bevacizumab in recurrent high-grade glioma.
Clin Cancer Res. 2018;24(19):4643-4649 - PMID: 29941486 - DOI: 10.1158/1078-0432.CCR-18-1025
Grassberger C, Hong TS, Hato T, Yeap BY, Wo JY, Tracy M, Bortfeld T, Wolfgang JA, Eyler CE, Goyal L, Clark JW, Crane CH, Koay EJ, Cobbold M, DeLaney TF, Jain RK, Zhu AX, Duda DG
Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Int J Radiat Oncol Biol Phys. 2018;101(5):1222-1225 - PMID: 29859792 - PMCID: PMC6050125 - DOI: 10.1016/j.ijrobp.2018.04.026
Nathanson SD, Krag D, Kuerer HM, Newman LA, Brown M, Kerjaschki D, Pereira ER, Padera TP
Breast cancer metastasis through the lympho-vascular system.
Clin Exp Metastasis. 2018;35(5-6):443-454 - PMID: 29796854 - DOI: 10.1007/s10585-018-9902-1
Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW
Consensus guidelines for the use and interpretation of angiogenesis assays.
Angiogenesis. 2018;21(3):425-532 - PMID: 29766399 - PMCID: PMC6237663 - DOI: 10.1007/s10456-018-9613-x
Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Nat Med. 2018;24(5):541-550 - PMID: 29686425 - PMCID: PMC5998822 - DOI: 10.1038/s41591-018-0014-x
Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Cancer Cell. 2018;33(5):874-889.e7 - PMID: 29681511 - PMCID: PMC6211172 - DOI: 10.1016/j.ccell.2018.03.020
Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK
Quantifying solid stress and elastic energy from excised or in situ tumors.
Nat Protoc. 2018;13(5):1091-1105 - PMID: 29674756 - DOI: 10.1038/nprot.2018.020
Carr JA, Franke D, Caram JR, Perkinson CF, Saif M, Askoxylakis V, Datta M, Fukumura D, Jain RK, Bawendi MG, Bruns OT
Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green.
Proc Natl Acad Sci U S A. 2018;115(17):4465-4470 - PMID: 29626132 - PMCID: PMC5924901 - DOI: 10.1073/pnas.1718917115
Pinter M, Kwanten WJ, Jain RK
Renin-angiotensin system inhibitors to mitigate cancer treatment-related adverse events.
Clin Cancer Res. 2018;24(16):3803-3812 - PMID: 29610292 - PMCID: PMC6095804 - DOI: 10.1158/1078-0432.CCR-18-0236
Jain RK, Batista A
A Physical View of Cancer.
Trends Cancer. 2018;4(4):257 - PMID: 29606305 - DOI: 10.1016/j.trecan.2018.03.001
Stylianopoulos T, Munn LL, Jain RK
Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.
Trends Cancer. 2018;4(4):258-259 - PMID: 29606306 - PMCID: PMC6161778 - DOI: 10.1016/j.trecan.2018.02.010
Stylianopoulos T, Munn LL, Jain RK
Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.
Trends Cancer. 2018;4(4):292-319 - PMID: 29606314 - PMCID: PMC5930008 - DOI: 10.1016/j.trecan.2018.02.005
Bourquard A, Pablo-Trinidad A, Butterworth I, Sánchez-Ferro Á, Cerrato C, Humala K, Fabra Urdiola M, Del Rio C, Valles B, Tucker-Schwartz JM, Lee ES, Vakoc BJ, Padera TP, Ledesma-Carbayo MJ, Chen YB, Hochberg EP, Gray ML, Castro-González C
Non-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculation.
Sci Rep. 2018;8(1):5301 - PMID: 29593221 - PMCID: PMC5871877 - DOI: 10.1038/s41598-018-23591-0
Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP
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Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma.
Transl Oncol. 2016;9(5):431-437 - PMID: 27751347 - PMCID: PMC5067928 - DOI: 10.1016/j.tranon.2016.07.004
Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.
Sci Transl Med. 2016;8(360):360ra135 - PMID: 27733559 - PMCID: PMC5457741 - DOI: 10.1126/scitranslmed.aaf5219
Bazou D, Ng MR, Song JW, Chin SM, Maimon N, Munn LL
Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting.
Sci Rep. 2016;6:34046 - PMID: 27669993 - PMCID: PMC5037418 - DOI: 10.1038/srep34046
Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK
Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27663981 - PMCID: PMC5131751 - DOI: 10.1101/cshperspect.a027094
Meijer EF, Baish JW, Padera TP, Fukumura D
Measuring Vascular Permeability In Vivo.
Methods Mol Biol. 2016;1458:71-85 - PMID: 27581015 - PMCID: PMC5435480 - DOI: 10.1007/978-1-4939-3801-8_6
Qazi H, Shi ZD, Song JW, Cancel LM, Huang P, Zeng Y, Roberge S, Munn LL, Tarbell JM
Heparan Sulfate Proteoglycans Mediate Renal Carcinoma Metastasis.
Int J Cancer. 2016;139(12):2791-2801 - PMID: 27543953 - DOI: 10.1002/ijc.30397
Ferraro GB, Kodack DP, Askoxylakis V, Jain RK
Closing the gap between astrocytes and brain metastasis progression.
Cell Res. 2016;26(9):973-4 - PMID: 27514701 - PMCID: PMC5034114 - DOI: 10.1038/cr.2016.96
Gupta N, Duda DG
Role of stromal cell-derived factor 1? pathway in bone metastatic prostate cancer.
J Biomed Res. 2016;30(3):181-185 - PMID: 27533927 - PMCID: PMC4885164 - DOI: 10.7555/JBR.30.20150114
Popp I, Grosu AL, Niedermann G, Duda DG
Immune modulation by hypofractionated stereotactic radiation therapy: Therapeutic implications.
Radiother Oncol. 2016;120(2):185-94 - PMID: 27495145 - DOI: 10.1016/j.radonc.2016.07.013
Chng KR, Chan SH, Ng AH, Li C, Jusakul A, Bertrand D, Wilm A, Choo SP, Tan DM, Lim KH, Soetinko R, Ong CK, Duda DG, Dima S, Popescu I, Wongkham C, Feng Z, Yeoh KG, Teh BT, Yongvanit P, Wongkham S, Bhudhisawasdi V, Khuntikeo N, Tan P, Pairojkul C, Ngeow J, Nagarajan N
Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma.
EBioMedicine. 2016;8:195-202 - PMID: 27428430 - PMCID: PMC4919562 - DOI: 10.1016/j.ebiom.2016.04.034
Blatter C, Meijer EF, Nam AS, Jones D, Bouma BE, Padera TP, Vakoc BJ
In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography.
Sci Rep. 2016;6:29035 - PMID: 27377852 - PMCID: PMC4932526 - DOI: 10.1038/srep29035
Han S, Ma X, Zhao Y, Zhao H, Batista A, Zhou S, Zhou X, Yang Y, Wang T, Bi J, Xia Z, Bai Z, Garkavtsev I, Zhang Z
Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer.
Oncotarget. 2016;7(28):44406-44416 - PMID: 27259271 - PMCID: PMC5190106 - DOI: 10.18632/oncotarget.9763
Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK
Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy.
Cancer Discov. 2016;6(8):852-69 - PMID: 27246539 - PMCID: PMC4972679 - DOI: 10.1158/2159-8290.CD-15-1177
Gruionu G, Bazou D, Maimon N, Onita-Lenco M, Gruionu LG, Huang P, Munn LL
Implantable tissue isolation chambers for analyzing tumor dynamics in vivo.
Lab Chip. 2016;16(10):1840-51 - PMID: 27128791 - PMCID: PMC5155583 - DOI: 10.1039/c6lc00237d
Patil MD, Bhaumik J, Babykutty S, Banerjee UC, Fukumura D
Arginine dependence of tumor cells: targeting a chink in cancer's armor.
Oncogene. 2016;35(38):4957-72 - PMID: 27109103 - PMCID: PMC5457742 - DOI: 10.1038/onc.2016.37
Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Proc Natl Acad Sci U S A. 2016;113(16):4470-5 - PMID: 27044097 - PMCID: PMC4843449 - DOI: 10.1073/pnas.1525349113
Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RK
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.
Proc Natl Acad Sci U S A. 2016;113(16):4476-81 - PMID: 27044098 - PMCID: PMC4843473 - DOI: 10.1073/pnas.1525360113
Setia N, Agoston AT, Han HS, Mullen JT, Duda DG, Clark JW, Deshpande V, Mino-Kenudson M, Srivastava A, Lennerz JK, Hong TS, Kwak EL, Lauwers GY
A protein and mRNA expression-based classification of gastric cancer.
Mod Pathol. 2016;29(7):772-84 - PMID: 27032689 - DOI: 10.1038/modpathol.2016.55
Blakeley JO, Ye X, Duda DG, Halpin CF, Bergner AL, Muzikansky A, Merker VL, Gerstner ER, Fayad LM, Ahlawat S, Jacobs MA, Jain RK, Zalewski C, Dombi E, Widemann BC, Plotkin SR
Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas.
J Clin Oncol. 2016;34(14):1669-75 - PMID: 26976425 - PMCID: PMC4872317 - DOI: 10.1200/JCO.2015.64.3817
Hayano K, Kulkarni NM, Duda DG, Heist RS, Sahani DV
Exploration of Imaging Biomarkers for Predicting Survival of Patients With Advanced Non-Small Cell Lung Cancer Treated With Antiangiogenic Chemotherapy.
AJR Am J Roentgenol. 2016;206(5):1-7 - PMID: 26934729 - DOI: 10.2214/AJR.15.15528
Padera TP, Meijer EF, Munn LL
The Lymphatic System in Disease Processes and Cancer Progression.
Annu Rev Biomed Eng. 2016;18:125-58 - PMID: 26863922 - PMCID: PMC4946986 - DOI: 10.1146/annurev-bioeng-112315-031200
Hato T, Zhu AX, Duda DG
Rationally combining anti-VEGF therapy with checkpoint inhibitors in hepatocellular carcinoma.
Immunotherapy. 2016;8(3):299-313 - PMID: 26865127 - PMCID: PMC5619018 - DOI: 10.2217/imt.15.126
Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam T, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop I, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D
PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity.
Clin Cancer Res. 2016;22(12):2993-3004 - PMID: 26861455 - PMCID: PMC4911258 - DOI: 10.1158/1078-0432.CCR-15-1839
Fukumura D, Incio J, Shankaraiah R, Jain RK
Obesity and cancer: an angiogenic and inflammatory link.
Microcirculation. 2016;23(3):191-206 - PMID: 26808917 - PMCID: PMC4818678 - DOI: 10.1111/micc.12270
Park KR, Monsky WL, Lee CG, Song CH, Kim DH, Jain RK, Fukumura D
Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability.
Radiat Res. 2016;185(2):182-189 - PMID: 26771172 - PMCID: PMC4761451 - DOI: 10.1667/RR14190.1
Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE
A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.
Sci Transl Med. 2016;8(320):320ra4 - PMID: 26738797 - PMCID: PMC4794335 - DOI: 10.1126/scitranslmed.aad0293
Kunert C, Baish JW, Liao S, Padera TP, Munn LL
Reply to Davis: Nitric oxide regulates lymphatic contractions.
Proc Natl Acad Sci U S A. 2016;113(2):E106 - PMID: 26719425 - PMCID: PMC4720299 - DOI: 10.1073/pnas.1522233113
Singhal PK, Sassi S, Lan L, Au P, Halvorsen SC, Fukumura D, Jain RK, Seed B
Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity.
Proc Natl Acad Sci U S A. 2016;113(1):122-7 - PMID: 26699463 - PMCID: PMC4711836 - DOI: 10.1073/pnas.1522401112
Askoxylakis V, Ferraro GB, Kodack DP, Badeaux M, Shankaraiah RC, Seano G, Kloepper J, Vardam T, Martin JD, Naxerova K, Bezwada D, Qi X, Selig MK, Brachtel E, Duda DG, Huang P, Fukumura D, Engelman JA, Jain RK
Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment.
J Natl Cancer Inst. 2016;108(2):ePub - PMID: 26547932 - PMCID: PMC4862418 - DOI: 10.1093/jnci/djv313
Datta M, Via LE, Chen W, Baish JW, Xu L, Barry CE, Jain RK
Mathematical Model of Oxygen Transport in Tuberculosis Granulomas.
Ann Biomed Eng. 2016;44(4):863-872 - PMID: 26253038 - PMCID: PMC4795989 - DOI: 10.1007/s10439-015-1415-3
Lee EQ, Kaley TJ, Duda DG, Schiff D, Lassman AB, Wong ET, Mikkelsen T, Purow BW, Muzikansky A, Ancukiewicz M, Huse JT, Ramkissoon S, Drappatz J, Norden AD, Beroukhim R, Weiss SE, Alexander BM, McCluskey CS, Gerard M, Smith KH, Jain RK, Batchelor TT, Ligon KL, Wen PY
A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients.
Clin Cancer Res. 2015;21(16):3610-8 - PMID: 25910950 - PMCID: PMC4790106 - DOI: 10.1158/1078-0432.CCR-14-3220
Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, Duda DG
CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.
Hepatology. 2015;61(5):1591-602 - PMID: 25529917 - PMCID: PMC4406806 - DOI: 10.1002/hep.27665
Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D
Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.
PLoS One. 2015;10(12):e0141392 - PMID: 26641266 - PMCID: PMC4671732 - DOI: 10.1371/journal.pone.0141392
Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, Winer EP, Krop IE, Jain RK
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.
Proc Natl Acad Sci U S A. 2015;112(46):14325-14330 - PMID: 26578779 - PMCID: PMC4655544 - DOI: 10.1073/pnas.1518808112
Gao X, Zhao Y, Stemmer-Rachamimov AO, Liu H, Huang P, Chin S, Selig MK, Plotkin SR, Jain RK, Xu L
Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model.
Proc Natl Acad Sci U S A. 2015;112(47):14676-81 - PMID: 26554010 - PMCID: PMC4664377 - DOI: 10.1073/pnas.1512570112
Samuel R, Duda DG, Fukumura D, Jain RK
Vascular diseases await translation of blood vessels engineered from stem cells.
Sci Transl Med. 2015;7(309):309rv6 - PMID: 26468328 - PMCID: PMC4799660 - DOI: 10.1126/scitranslmed.aaa1805
Chen Y, Duda DG
Targeting immunosuppression after standard sorafenib treatment to facilitate immune checkpoint blockade in hepatocellular carcinoma - an auto-commentary on clinical potential and future development.
Oncoimmunology. 2015;4(10):e1029703 - PMID: 26451297 - PMCID: PMC4589048 - DOI: 10.1080/2162402X.2015.1029703
Setia N, Clark JW, Duda DG, Hong TS, Kwak EL, Mullen JT, Lauwers GY
Familial Gastric Cancers.
Oncologist. 2015;20(12):1365-1377 - PMID: 26424758 - PMCID: PMC4679084 - DOI: 10.1634/theoncologist.2015-0205
Stylianopoulos T, Jain RK
Design considerations for nanotherapeutics in oncology.
Nanomedicine. 2015;11(8):1893-907 - PMID: 26282377 - PMCID: PMC4628869 - DOI: 10.1016/j.nano.2015.07.015
Kunert C, Baish JW, Liao S, Padera TP, Munn LL
Mechanobiological oscillators control lymph flow.
Proc Natl Acad Sci U S A. 2015;112(35):10938-43 - PMID: 26283382 - PMCID: PMC4568261 - DOI: 10.1073/pnas.1508330112
Jain RK, Fukumura D, Duda DG
From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey.
Cancer J. 2015;21(4):235-236 - PMID: 26222072 - PMCID: PMC4791947 - DOI: 10.1097/PPO.0000000000000136
Batista A, Riedemann L, Vardam T, Jain RK
Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment.
Cancer J. 2015;21(4):307-313 - PMID: 26222083 - DOI: 10.1097/PPO.0000000000000125
Reiberger T, Chen Y, Ramjiawan RR, Hato T, Fan C, Samuel R, Roberge S, Huang P, Lauwers GY, Zhu AX, Bardeesy N, Jain RK, Duda DG
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Nat Protoc. 2015;10(8):1264-1274 - PMID: 26203823 - PMCID: PMC4800979 - DOI: 10.1038/nprot.2015.080
Goyal L, Chong DQ, Duda DG, Zhu AX
Chemotherapy and antiangiogenics in biliary tract cancer.
Lancet Oncol. 2015;16(8):882-3 - PMID: 26179202 - DOI: 10.1016/S1470-2045(15)00093-5
Lemon CM, Karnas E, Han X, Bruns OT, Kempa TJ, Fukumura D, Bawendi MG, Jain RK, Duda DG, Nocera DG
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.
J Am Chem Soc. 2015;137(31):9832-42 - PMID: 26149349 - PMCID: PMC4750386 - DOI: 10.1021/jacs.5b04765
Zou HY, Friboulet L, Kodack DP, Engstrom LD, Li Q, West M, Tang RW, Wang H, Tsaparikos K, Wang J, Timofeevski S, Katayama R, Dinh DM, Lam H, Lam JL, Yamazaki S, Hu W, Patel B, Bezwada D, Frias RL, Lifshits E, Mahmood S, Gainor JF, Affolter T, Lappin PB, Gukasyan H, Lee N, Deng S, Jain RK, Johnson TW, Shaw AT, Fantin VR, Smeal T
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Cancer Cell. 2015;28(1):70-81 - PMID: 26144315 - PMCID: PMC4504786 - DOI: 10.1016/j.ccell.2015.05.010
Duda DG, Heist RS, Sahani DV, Stylianopoulos T, Engelman JA, Jain RK
Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.
Proc Natl Acad Sci U S A. 2015;112(27):E3454 - PMID: 26080434 - PMCID: PMC4500270 - DOI: 10.1073/pnas.1507225112
Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP
Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.
J Natl Cancer Inst. 2015;107(9):ePub - PMID: 26063793 - PMCID: PMC4651102 - DOI: 10.1093/jnci/djv155
Jain RK, Fukumura D, Duda DG
Lessons From 30 Years of Teaching About the Microenvironment of Tumors.
Cancer J. 2015;21(3):137 - PMID: 26049690 - PMCID: PMC4792516 - DOI: 10.1097/PPO.0000000000000119
Gerstner ER, Ye X, Duda DG, Levine MA, Mikkelsen T, Kaley TJ, Olson JJ, Nabors BL, Ahluwalia MS, Wen PY, Jain RK, Batchelor TT, Grossman S
A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma.
Neuro Oncol. 2015;17(10):1386-92 - PMID: 26008604 - PMCID: PMC4578584 - DOI: 10.1093/neuonc/nov085
Kesler CT, Pereira ER, Cui CH, Nelson GM, Masuck DJ, Baish JW, Padera TP
Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation.
FASEB J. 2015;29(9):3668-77 - PMID: 25977256 - PMCID: PMC4550378 - DOI: 10.1096/fj.14-268920
Cho JK, Hyun SH, Choi N, Kim MJ, Padera TP, Choi JY, Jeong HS
Significance of lymph node metastasis in cancer dissemination of head and neck cancer.
Transl Oncol. 2015;8(2):119-25 - PMID: 25926078 - PMCID: PMC4415144 - DOI: 10.1016/j.tranon.2015.03.001
Choi JW, Kim P, Kim JK, Kim YR, Fukumura D, Yun SH
Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis.
Theranostics. 2015;5(7):724-32 - PMID: 25897337 - PMCID: PMC4402496 - DOI: 10.7150/thno.10734
Padera TP
Editorial.
Semin Cell Dev Biol. 2015;38:53-4 - PMID: 25868083 - DOI: 10.1016/j.semcdb.2015.03.007
Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI
Local Failure in Parameningeal Rhabdomyosarcoma Correlates With Poor Response to Induction Chemotherapy.
Int J Radiat Oncol Biol Phys. 2015;92(2):358-67 - PMID: 25864172 - PMCID: PMC5479480 - DOI: 10.1016/j.ijrobp.2015.01.049
Hayano K, Tian F, Kambadakone AR, Yoon SS, Duda DG, Ganeshan B, Sahani DV
Texture Analysis of Non-Contrast-Enhanced Computed Tomography for Assessing Angiogenesis and Survival of Soft Tissue Sarcoma.
J Comput Assist Tomogr. 2015;39(4):607-612 - PMID: 25793653 - PMCID: PMC4504795 - DOI: 10.1097/RCT.0000000000000239
Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK
Lessons From Anti-Vascular Endothelial Growth Factor and Anti-Vascular Endothelial Growth Factor Receptor Trials in Patients With Glioblastoma.
J Clin Oncol. 2015;33(10):1197-213 - PMID: 25713439 - PMCID: PMC4517055 - DOI: 10.1200/JCO.2014.55.9575
Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK
Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.
J Natl Cancer Inst. 2015;107(4):ePub - PMID: 25710962 - PMCID: PMC4402365 - DOI: 10.1093/jnci/djv017
Kodack DP, Askoxylakis V, Ferraro GB, Fukumura D, Jain RK
Emerging Strategies for Treating Brain Metastases from Breast Cancer.
Cancer Cell. 2015;27(2):163-175 - PMID: 25670078 - PMCID: PMC4325273 - DOI: 10.1016/j.ccell.2015.01.001
Stylianopoulos T, Economides EA, Baish JW, Fukumura D, Jain RK
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors.
Ann Biomed Eng. 2015;43(9):2291-300 - PMID: 25670323 - PMCID: PMC4519365 - DOI: 10.1007/s10439-015-1276-9
Munn LL
Mechanobiology of lymphatic contractions.
Semin Cell Dev Biol. 2015;38:67-74 - PMID: 25636584 - DOI: 10.1016/j.semcdb.2015.01.010
Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK
Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery.
Proc Natl Acad Sci U S A. 2015;112(6):1827-32 - PMID: 25624495 - PMCID: PMC4330784 - DOI: 10.1073/pnas.1424563112
Pereira ER, Jones D, Jung K, Padera TP
The lymph node microenvironment and its role in the progression of metastatic cancer.
Semin Cell Dev Biol. 2015;38:98-105 - PMID: 25620792 - PMCID: PMC4397158 - DOI: 10.1016/j.semcdb.2015.01.008
Han HS, Niemeyer E, Huang Y, Kamoun WS, Martin JD, Bhaumik J, Chen Y, Roberge S, Cui J, Martin MR, Fukumura D, Jain RK, Bawendi MG, Duda DG
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice.
Proc Natl Acad Sci U S A. 2015;112(5):1350-5 - PMID: 25605916 - PMCID: PMC4321304 - DOI: 10.1073/pnas.1421632111
Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, Temel JS, Shaw AT, Pennell NA, Neal JW, Gandhi L, Lynch TJ, Engelman JA, Jain RK
Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.
Proc Natl Acad Sci U S A. 2015;112(5):1547-52 - PMID: 25605928 - PMCID: PMC4321320 - DOI: 10.1073/pnas.1424024112
Naxerova K, Jain RK
Using tumour phylogenetics to identify the roots of metastasis in humans.
Nat Rev Clin Oncol. 2015;12(5):258-272 - PMID: 25601447 - DOI: 10.1038/nrclinonc.2014.238
Kuo AH, Ancukiewicz M, Kozak KR, Yock TI, Padera TP
Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation.
Radiat Oncol. 2015;10(1):5 - PMID: 25573181 - PMCID: PMC4293110 - DOI: 10.1186/s13014-014-0324-1
Kambadakone A, Yoon SS, Kim TM, Karl DL, Duda DG, DeLaney TF, Sahani DV
CT Perfusion as an Imaging Biomarker in Monitoring Response to Neoadjuvant Bevacizumab and Radiation in Soft-Tissue Sarcomas: Comparison With Tumor Morphology, Circulating and Tumor Biomarkers, and Gene Expression.
AJR Am J Roentgenol. 2015;204(1):W11-8 - PMID: 25539263 - PMCID: PMC4479405 - DOI: 10.2214/AJR.13.12412
Stroh M, Duda DG, Takimoto CH, Yamazaki S, Vicini P
Translation of anticancer efficacy from nonclinical models to the clinic.
CPT Pharmacometrics Syst Pharmacol. 2014;3:e128 - PMID: 25098530 - PMCID: PMC4150926 - DOI: 10.1038/psp.2014.28
Gerweck LE, Huang P, Lu HM, Paganetti H, Zhou Y
Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons.
Int J Radiat Oncol Biol Phys. 2014;89(1):161-6 - PMID: 24725699 - PMCID: PMC4298825 - DOI: 10.1016/j.ijrobp.2014.01.057
Babykutty S, Heishi T, Tsukada K, Huang Y, Kozin S, Conner D, Lin Q, Kucherlapati R, Jain RK, Fukumura D
Restoring perivascular nitric oxide gradients normalizes breast cancer vasculature.
Nitric Oxide. 2014;42C:115 - PMID: 25519573
Jain RK
Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia.
Cancer Cell. 2014;26(5):605-622 - PMID: 25517747 - PMCID: PMC4269830 - DOI: 10.1016/j.ccell.2014.10.006
Zhang L, Li K, Sun R, Zhang Y, Ji J, Huang P, Yang H, Tian Y
Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study.
Radiat Oncol. 2014;9(1):281 - PMID: 25498371 - PMCID: PMC4271325 - DOI: 10.1186/s13014-014-0281-8
Liao S, Jones D, Cheng G, Padera TP
Method for the quantitative measurement of collecting lymphatic vessel contraction in mice.
J Biol Methods. 2014;1(2):ePub - PMID: 25512945 - PMCID: PMC4264607 - DOI: 10.14440/jbm.2014.26
Song JW, Bazou D, Munn LL
Microfluidic model of angiogenic sprouting.
Methods Mol Biol. 2014;1214:243-54 - PMID: 25468609 - DOI: 10.1007/978-1-4939-1462-3_15
Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R
Correlative intravital imaging of cGMP signals and vasodilation in mice.
Front Physiol. 2014;5:394 - PMID: 25352809 - PMCID: PMC4196583 - DOI: 10.3389/fphys.2014.00394
Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, Cordero JM, Wang Z, Jasanoff A, Fukumura D, Reimer R, Dahan M, Jain RK, Bawendi MG
Magneto-fluorescent core-shell supernanoparticles.
Nat Commun. 2014;5:5093 - PMID: 25298155 - PMCID: PMC4264679 - DOI: 10.1038/ncomms6093
Li W, Huang P, Chen DJ, Gerweck LE
Determinates of tumor response to radiation: Tumor cells, tumor stroma and permanent local control.
Radiother Oncol. 2014;113(1):146-9 - PMID: 25284063 - PMCID: PMC4280081 - DOI: 10.1016/j.radonc.2014.09.006
Jain RK, Netti PA
Letter to the editor regarding recent article by Wu et Al. [journal of theoretical biology, 355, 194-207 (2014)].
J Theor Biol. 2014;363C:453 - PMID: 25219622 - DOI: 10.1016/j.jtbi.2014.08.052
Seano G, Chiaverina G, Gagliardi PA, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L
Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.
Nat Cell Biol. 2014;16(10):931-941 - PMID: 25218639 - PMCID: PMC4564017 - DOI: 10.1038/ncb3036
Richter C, Seco J, Hong TS, Duda DG, Bortfeld T
Radiation-induced changes in hepatocyte-specific Gd-EOB-DTPA enhanced MRI: Potential mechanism.
Med Hypotheses. 2014;83(4):477-81 - PMID: 25175713 - DOI: 10.1016/j.mehy.2014.08.004
Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen B, Loeffler JS, Wen PY, Sorensen AG, Jain RK
Increased perfusion due to vascular normalization improves oxygenation and survival in glioblastoma patients treated with cediranib with or without chemoradiation.
Neuro Oncol. 2014;16 Suppl 3:iii12 - PMID: 25165209 - PMCID: PMC4144509
Emblem KE, Farrar CT, Gerstner ER, Batchelor TT, Borra RJ, Rosen BR, Sorensen AG, Jain RK
Vessel calibre-a potential MRI biomarker of tumour response in clinical trials.
Nat Rev Clin Oncol. 2014;11(10):566-584 - PMID: 25113840 - PMCID: PMC4445139 - DOI: 10.1038/nrclinonc.2014.126
Duda DG, Ancukiewicz M, Isakoff SJ, Krop IE, Jain RK
Seeds and soil: unraveling the role of local tumor stroma in distant metastasis.
J Natl Cancer Inst. 2014;106(8):ePub - PMID: 25082335 - DOI: 10.1093/jnci/dju187
Jain RK, Fukumura D, Duda DG
Modes of neovascularization in tumors and clinical translation of antiangiogenic therapy.
In: Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (Editor: LM McManus & RN Mitchell). Elsevier Press, Oxford. 2014;:(in press)
Chung E, Yeon C, Jain RK, Fukumura D
Uncovering tumor biology by intravital microscopy.
In: Comprehensive Biomedical Physics, Volume: IV 'Optical molecular imaging' (Editor: Kiessling Alves & Anders Brahme). Elsevier Press. 2014;:(in press)
Jain RK, Duda DG
Molecular Pathophysiology of Tumors.
In: Principles and Practice of Radiation Oncology, 6th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2014;Chapter 4:(in press)
Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA
Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Proc Natl Acad Sci U S A. 2014;111(30):E3091-100 - PMID: 25024225 - PMCID: PMC4121834 - DOI: 10.1073/pnas.1411679111
Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK
Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure.
Cancer Cell. 2014;26(1):14-15 - PMID: 25026209 - PMCID: PMC4381566 - DOI: 10.1016/j.ccr.2014.06.003
Jain RK, Martin JD, Stylianopoulos T
The role of mechanical forces in tumor growth and therapy.
Annu Rev Biomed Eng. 2014;16:321-46 - PMID: 25014786 - PMCID: PMC4109025 - DOI: 10.1146/annurev-bioeng-071813-105259
Wang Y, Li W, Patel SS, Cong J, Zhang N, Sabbatino F, Liu X, Qi Y, Huang P, Lee H, Taghian A, Li JJ, DeLeo AB, Ferrone S, Epperly MW, Ferrone CR, Ly A, Brachtel EF, Wang X
Blocking the formation of radiation-induced breast cancer stem cells.
Oncotarget. 2014;5(11):3743-55 - PMID: 25003837 - PMCID: PMC4116517 - DOI: 10.18632/oncotarget.1992
Munn LL, Padera TP
Imaging the Lymphatic System.
Microvasc Res. 2014;96C:55-63 - PMID: 24956510 - PMCID: PMC4268344 - DOI: 10.1016/j.mvr.2014.06.006
Hato T, Goyal L, Greten TF, Duda DG, Zhu AX
Immune checkpoint blockade in hepatocellular carcinoma: Current progress and future directions.
Hepatology. 2014;60(5):1776-82 - PMID: 24912948 - PMCID: PMC4211962 - DOI: 10.1002/hep.27246
Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-Del Castillo C, Duda DG
A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma.
Int J Radiat Oncol Biol Phys. 2014;89(4):830-8 - PMID: 24867540 - PMCID: PMC4791180 - DOI: 10.1016/j.ijrobp.2014.03.034
Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK
Hypermutable DNA chronicles the evolution of human colon cancer.
Proc Natl Acad Sci U S A. 2014;111(18):E1889-98 - PMID: 24753616 - PMCID: PMC4020055 - DOI: 10.1073/pnas.1400179111
Cucu D, Chiritoiu G, Petrescu S, Babes A, Stanica L, Duda DG, Horii A, Dima SO, Popescu I
Characterization of Functional Transient Receptor Potential Melastatin 8 Channels in Human Pancreatic Ductal Adenocarcinoma Cells.
Pancreas. 2014;43(5):795-800 - PMID: 24658318 - DOI: 10.1097/MPA.0000000000000106
Schwabl P, Payer BA, Grahovac J, Klein S, Horvatits T, Mitterhauser M, Stift J, Boucher Y, Trebicka J, Trauner M, Angermayr B, Fuhrmann V, Reiberger T, Peck-Radosavljevic M
Pioglitazone decreases portosystemic shunting by modulating inflammation and angiogenesis in cirrhotic and non-cirrhotic portal hypertensive rats.
J Hepatol. 2014;60(6):1135-42 - PMID: 24530596 - DOI: 10.1016/j.jhep.2014.01.025
Jain RK
An indirect way to tame cancer
Sci Am. 2014;310(2):46-53 - PMID: 24640331
Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER
Low Incidence of Pseudoprogression by Imaging in Newly Diagnosed Glioblastoma Patients Treated With Cediranib in Combination With Chemoradiation.
Oncologist. 2014;19(1):75-81 - PMID: 24309981 - PMCID: PMC3903059 - DOI: 10.1634/theoncologist.2013-0101
Chen Y, Huang Y, Reiberger T, Duyverman AM, Huang P, Samuel R, Hiddingh L, Roberge S, Koppel C, Lauwers GY, Zhu AX, Jain RK, Duda DG
Differential effects of sorafenib on liver versus tumor fibrosis mediated by SDF1a/CXCR4 axis and Gr-1+ myeloid cell infiltration in mice.
Hepatology. 2014;59(4):1435-47 - PMID: 24242874 - PMCID: PMC3966948 - DOI: 10.1002/hep.26790
Hagendoorn J, Yock TI, Borel Rinkes IH, Padera TP, Ebb DH
Novel molecular pathways in Gorham disease: Implications for treatment.
Pediatr Blood Cancer. 2014;61(3):401-6 - PMID: 24214028 - PMCID: PMC4123459 - DOI: 10.1002/pbc.24832
Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP
Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells.
Angiogenesis. 2014;17(2):419-27 - PMID: 24201897 - PMCID: PMC3981926 - DOI: 10.1007/s10456-013-9400-7
Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, Corcoran RB, Rivera MN, Ramaswamy S, Hung KE, Benes CH, Engelman JA
mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL inhibition by Suppressing MCL-1.
Cancer Discov. 2014;4(1):42-52 - PMID: 24163374 - PMCID: PMC3973435 - DOI: 10.1158/2159-8290.CD-13-0315
Lemon CM, Curtin PN, Somers RC, Greytak AB, Lanning RM, Jain RK, Bawendi MG, Nocera DG
Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.
Inorg Chem. 2014;53(4):1900-15 - PMID: 24143874 - PMCID: PMC3944830 - DOI: 10.1021/ic401587r
Duda DG
Molecular Biomarkers of Response to Antiangiogenic Therapy for Cancer.
ISRN Cell Biol. 2013;2012:ePub - PMID: 24340224 - PMCID: PMC3856765 - DOI: 10.5402/2012/587259
Munn LL
Dynamics of tissue topology during cancer invasion and metastasis.
Phys Biol. 2013;10(6):065003 - PMID: 24304856 - PMCID: PMC4324506 - DOI: 10.1088/1478-3975/10/6/065003
Chan-On W, Nairismägi ML, Ong CK, Lim WK, Dima S, Pairojkul C, Lim KH, McPherson JR, Cutcutache I, Heng HL, Ooi L, Chung A, Chow P, Cheow PC, Lee SY, Choo SP, Tan IB, Duda D, Nastase A, Myint SS, Wong BH, Gan A, Rajasegaran V, Ng CC, Nagarajan S, Jusakul A, Zhang S, Vohra P, Yu W, Huang D, Sithithaworn P, Yongvanit P, Wongkham S, Khuntikeo N, Bhudhisawasdi V, Popescu I, Rozen SG, Tan P, Teh BT
Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.
Nat Genet. 2013;45(12):1474-8 - PMID: 24185513 - DOI: 10.1038/ng.2806
Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK
Benefits of Vascular Normalization Are Dose and Time Dependent--Letter.
Cancer Res. 2013;73(23):7144-6 - PMID: 24265277 - PMCID: PMC3876035 - DOI: 10.1158/0008-5472.CAN-13-1989
Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Proc Natl Acad Sci U S A. 2013;110(47):19059-64 - PMID: 24190997 - PMCID: PMC3839699 - DOI: 10.1073/pnas.1318022110
Stylianopoulos T, Jain RK
Combining two strategies to improve perfusion and drug delivery in solid tumors.
Proc Natl Acad Sci U S A. 2013;110(46):18632-7 - PMID: 24167277 - PMCID: PMC3832007 - DOI: 10.1073/pnas.1318415110
Chauhan VP, Jain RK
Strategies for advancing cancer nanomedicine.
Nat Mater. 2013;12(11):958-62 - PMID: 24150413 - PMCID: PMC4120281 - DOI: 10.1038/nmat3792
Zhu AX, Finn RS, Mulcahy M, Gurtler J, Sun W, Schwartz JD, Dalal RP, Joshi A, Hozak RR, Xu Y, Ancukiewicz M, Jain RK, Nugent F, Duda DG, Stuart K
A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2 in Patients with Advanced Hepatocellular Cancer.
Clin Cancer Res. 2013;19(23):6614-23 - PMID: 24088738 - PMCID: PMC4795808 - DOI: 10.1158/1078-0432.CCR-13-1442
Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Nat Commun. 2013;4:2516 - PMID: 24084631 - PMCID: PMC3806395 - DOI: 10.1038/ncomms3516
Qazi H, Palomino R, Shi ZD, Munn LL, Tarbell JM
Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion.
Integr Biol (Camb). 2013;5(11):1334-43 - PMID: 24077103 - PMCID: PMC4249644 - DOI: 10.1039/c3ib40057c
Liao S, Padera TP
Lymphatic Function and Immune Regulation in Health and Disease.
Lymphat Res Biol. 2013;11(3):136-43 - PMID: 24024577 - PMCID: PMC3780287 - DOI: 10.1089/lrb.2013.0012
Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
Nat Med. 2013;19(9):1178-83 - PMID: 23955713 - PMCID: PMC3769525 - DOI: 10.1038/nm.3289
Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, Mason W, Mikkelsen T, Phuphanich S, Ashby LS, Degroot J, Gattamaneni R, Cher L, Rosenthal M, Payer F, Jürgensmeier JM, Jain RK, Sorensen AG, Xu J, Liu Q, van den Bent M
Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma.
J Clin Oncol. 2013;31(26):3212-3218 - PMID: 23940216 - PMCID: PMC4021043 - DOI: 10.1200/JCO.2012.47.2464
Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK
Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164
Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
Proc Natl Acad Sci U S A. 2013;110(31):12774-9 - PMID: 23861493 - PMCID: PMC3732948 - DOI: 10.1073/pnas.1310675110
Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, Dietrich J, Stemmer-Rachamimov AO, Batchelor TT, Jain RK
Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
Neuro Oncol. 2013;15(8):1079-87 - PMID: 23828240 - PMCID: PMC3714160 - DOI: 10.1093/neuonc/not082
Sahani DV, Jiang T, Hayano K, Duda DG, Catalano OA, Ancukiewicz M, Jain RK, Zhu AX
Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy.
J Hematol Oncol. 2013;6(1):51 - PMID: 23842041 - PMCID: PMC3722053 - DOI: 10.1186/1756-8722-6-51
Jain RK, Munn LL, Fukumura D
Measuring Interstitial pH and pO2 in Mouse Tumors.
Cold Spring Harb Protoc. 2013;2013(7):675-7 - PMID: 23818669 - DOI: 10.1101/pdb.prot075713
Jain RK, Munn LL, Fukumura D
Measuring interstitial diffusion, convection, and binding parameters in mouse tumors.
Cold Spring Harb Protoc. 2013;2013(7):678-80 - PMID: 23818670 - DOI: 10.1101/pdb.prot075721
Thunemann M, Wen L, Hillenbrand M, Vachaviolos IA, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R
Transgenic Mice for cGMP Imaging.
Circ Res. 2013;113(4):365-71 - PMID: 23801067 - PMCID: PMC3896241 - DOI: 10.1161/CIRCRESAHA.113.301063
Jain RK, Munn LL, Fukumura D
Measuring leukocyte-endothelial interactions in mice.
Cold Spring Harb Protoc. 2013;2013(6):561-3 - PMID: 23734020 - DOI: 10.1101/pdb.prot075085
Jain RK
Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers.
J Clin Oncol. 2013;31(17):2205-18 - PMID: 23669226 - PMCID: PMC3731977 - DOI: 10.1200/JCO.2012.46.3653
Duda DG, Munn LL, Jain RK
Can We Identify Predictive Biomarkers for Antiangiogenic Therapy of Cancer Using Mathematical Modeling?
J Natl Cancer Inst. 2013;105(11):762-5 - PMID: 23670727 - PMCID: PMC3672078 - DOI: 10.1093/jnci/djt114
Stylianopoulos T, Martin JD, Snuderl M, Mpekris F, Jain SR, Jain RK
Co-evolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse.
Cancer Res. 2013;73(13):3833-3841 - PMID: 23633490 - PMCID: PMC3702668 - DOI: 10.1158/0008-5472.CAN-12-4521
Jain RK, Munn LL, Fukumura D
Measuring vascular permeability in mice.
Cold Spring Harb Protoc. 2013;2013(5):444-6 - PMID: 23637370 - DOI: 10.1101/pdb.prot074344
Jain RK, Munn LL, Fukumura D
Measuring angiogenesis and hemodynamics in mice.
Cold Spring Harb Protoc. 2013;2013(4):354-8 - PMID: 23547161 - DOI: 10.1101/pdb.prot073916
Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Cell. 2013;152(5):1065-76 - PMID: 23452854 - PMCID: PMC3587980 - DOI: 10.1016/j.cell.2013.01.036
Huang Y, Goel S, Duda DG, Fukumura D, Jain RK
Vascular normalization as an emerging strategy to enhance cancer immunotherapy.
Cancer Res. 2013;73(10):2943-8 - PMID: 23440426 - PMCID: PMC3655127 - DOI: 10.1158/0008-5472.CAN-12-4354
Prabhakar U, Blakey DC, Maeda H, Jain RK, Sevick-Muraca EM, Zamboni W, Farokhzad OC, Barry ST, Gabizon A, Grodzinski P
Challenges and key considerations of the enhanced permeability and retention effect (EPR) for nanomedicine drug delivery in oncology.
Cancer Res. 2013;73(8):2412-2417 - PMID: 23423979 - PMCID: PMC3916009 - DOI: 10.1158/0008-5472.CAN-12-4561
Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, Bawendi MG
Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.
Nat Mater. 2013;12(5):445-51 - PMID: 23377294 - PMCID: PMC3677691 - DOI: 10.1038/nmat3539
Zhu AX, Ancukiewicz M, Supko JG, Sahani DV, Blaszkowsky LS, Meyerhardt JA, Abrams TA, Jackson McCleary N, Bhargava P, Muzikansky A, Sheehan S, Regan E, Vasudev E, Knowles M, Fuchs CS, Ryan DP, Jain RK, Duda DG
Efficacy, safety, pharmacokinetics and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: A phase II study.
Clin Cancer Res. 2013;19(6):1557-66 - PMID: 23362324 - PMCID: PMC3609423 - DOI: 10.1158/1078-0432.CCR-12-3041
Jain RK, Munn LL, Fukumura D
Lung window preparation in mice.
Cold Spring Harb Protoc. 2013;2013(1):ePub - PMID: 23282642 - DOI: 10.1101/pdb.prot072678
Han HS, Martin JD, Lee J, Harris DK, Fukumura D, Jain RK, Bawendi M
Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo.
Angew Chem Int Ed Engl. 2013;52(5):1414-9 - PMID: 23255143 - PMCID: PMC3755124 - DOI: 10.1002/anie.201208331
Stylianopoulos T, Soteriou K, Fukumura D, Jain RK
Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model.
Ann Biomed Eng. 2013;41(1):68-77 - PMID: 22855118 - PMCID: PMC3886728 - DOI: 10.1007/s10439-012-0630-4
Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG, Nocera DG
A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.
Chem Sci. 2012;3(10):2980-2985 - PMID: 26413260 - PMCID: PMC4582792 - DOI: 10.1039/C2SC20212C
Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG and Nocera DG
A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.
Chemical Science. 2012;:ePub
Jain RK
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2012;64(Suppl):353-365 - PMID: 24511174 - PMCID: PMC3914635 - DOI: 10.1016/j.addr.2012.09.011
Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK
Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment.
Intravital. 2012;1(1):ePub - PMID: 24353926 - PMCID: PMC3864876 - DOI: 10.4161/intv.21557
Kesler CT, Liao S, Munn LL, Padera TP
Lymphatic vessels in health and disease.
Wiley Interdiscip Rev Syst Biol Med. 2012;5(1):111-24 - PMID: 23209022 - PMCID: PMC3527689 - DOI: 10.1002/wsbm.1201
Jain RK, Munn LL, Fukumura D
Pancreatic tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209145 - DOI: 10.1101/pdb.prot072363
Jain RK, Munn LL, Fukumura D
Liver tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209146 - DOI: 10.1101/pdb.prot072371
Jain RK, Munn LL, Fukumura D
Lymphangiography of the mouse tail.
Cold Spring Harb Protoc. 2012;2012(11):1177-8 - PMID: 23118364 - DOI: 10.1101/pdb.prot072108
Jain RK, Munn LL, Fukumura D
Lymphangiography of the mouse ear.
Cold Spring Harb Protoc. 2012;2012(11):1179-80 - PMID: 23118365 - DOI: 10.1101/pdb.prot072116
Song JW, Daubriac J, Tse JM, Bazou D, Munn LL
RhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis.
Lab Chip. 2012;12(23):5000-6 - PMID: 23073300 - PMCID: PMC3490212 - DOI: 10.1039/c2lc40389g
Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Proc Natl Acad Sci U S A. 2012;109(45):E3119-27 - PMID: 23071298 - PMCID: PMC3494882 - DOI: 10.1073/pnas.1216078109
Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Proc Natl Acad Sci U S A. 2012;109(43):17561-6 - PMID: 23045683 - PMCID: PMC3491458 - DOI: 10.1073/pnas.1215397109
Jain RK, Munn LL, Fukumura D
Mammary fat pad chamber preparation in mice.
Cold Spring Harb Protoc. 2012;2012(10):1113-4 - PMID: 23028075 - DOI: 10.1101/pdb.prot071506
Jain RK, Munn LL, Fukumura D
Mammary fat pad tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(10):1115-6 - PMID: 23028076 - DOI: 10.1101/pdb.prot071514
Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L
TGF-? blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2012;109(41):16618-23 - PMID: 22996328 - PMCID: PMC3478596 - DOI: 10.1073/pnas.1117610109
Jain RK
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2012;:ePub - PMID: 22983334
Duda DG, Willett CG
Going beyond systemic fluoropyrimidines with radiation therapy for rectal cancer: what should be the priority?
Oncology (Williston Park). 2012;26(8):741-3 - PMID: 22957407 - PMCID: PMC3682651
Jain RK, Munn LL, Fukumura D
Corneal pocket assay in rabbits.
Cold Spring Harb Protoc. 2012;2012(9):1017-8 - PMID: 22949714 - DOI: 10.1101/pdb.prot070052
Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Proc Natl Acad Sci U S A. 2012;109(38):15101-8 - PMID: 22932871 - PMCID: PMC3458380 - DOI: 10.1073/pnas.1213353109
Sorensen AG, Emblem KE, Polaskova P, Jennings D, Kim H, Ancukiewicz M, Wang M, Wen PY, Ivy P, Batchelor TT, Jain RK
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.
Cancer Res. 2012;72(2):402-7 - PMID: 22127927 - PMCID: PMC3261301 - DOI: 10.1158/0008-5472.CAN-11-2464
Goel S, Wong AH, Jain RK
Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
Cold Spring Harb Perspect Med. 2012;2(3):a006486 - PMID: 22393532 - PMCID: PMC3282493 - DOI: 10.1101/cshperspect.a006486
Plotkin SR, Bredella MA, Cai W, Kassarjian A, Harris GJ, Esparza S, Merker VL, Munn LL, Muzikansky A, Askenazi M, Nguyen R, Wenzel R, Mautner VF
Quantitative assessment of whole-body tumor burden in adult patients with neurofibromatosis.
PLoS One. 2012;7(4):e35711 - PMID: 22558206 - PMCID: PMC3338705 - DOI: 10.1371/journal.pone.0035711
Song JW, Bazou D, Munn LL
Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis.
Integr Biol (Camb). 2012;4(8):857-62 - PMID: 22673771 - PMCID: PMC3759296 - DOI: 10.1039/c2ib20061a
Jain RK, Carmeliet P
SnapShot: Tumor angiogenesis.
Cell. 2012;149(6):1408-1408.e1 - PMID: 22682256 - DOI: 10.1016/j.cell.2012.05.025
Meyerhardt JA, Ancukiewicz M, Abrams TA, Schrag D, Enzinger PC, Chan JA, Kulke MH, Wolpin BM, Goldstein M, Blaszkowsky L, Zhu AX, Elliott M, Regan E, Jain RK, Duda DG
Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.
PLoS One. 2012;7(6):e38231 - PMID: 22701615 - PMCID: PMC3373492 - DOI: 10.1371/journal.pone.0038231
Dima SO, Tanase C, Albulescu R, Herlea V, Chivu-Economescu M, Purnichescu-Purtan R, Dumitrascu T, Duda DG, Popescu I
An Exploratory Study of Inflammatory Cytokines as Prognostic Biomarkers in Patients With Ductal Pancreatic Adenocarcinoma.
Pancreas. 2012;41(7):1001-7 - PMID: 22722257 - DOI: 10.1097/MPA.0b013e3182546e13
Jain RK, Munn LL, Fukumura D
Rabbit ear chambers.
Cold Spring Harb Protoc. 2012;2012(7):813-14 - PMID: 22753607 - DOI: 10.1101/pdb.prot070045
Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK
Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.
Neoplasia. 2012;14(2):84-94 - PMID: 22431917 - PMCID: PMC3306254 - DOI: 10.1593/neo.111600
Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK
Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Annu Rev Chem Biomol Eng. 2012;2:281-98 - PMID: 22432620 - DOI: 10.1146/annurev-chembioeng-061010-114300
Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Boucher Y, Jain RK, Munn LL
Mechanical compression drives cancer cells toward invasive phenotype.
Proc Natl Acad Sci U S A. 2012;109(3):911-6 - PMID: 22203958 - PMCID: PMC3271885 - DOI: 10.1073/pnas.1118910109
Saylor PJ, Kozak KR, Smith MR, Ancukiewicz MA, Efstathiou JA, Zietman AL, Jain RK, Duda DG
Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer.
Oncologist. 2012;17(2):212-9 - PMID: 22302227 - PMCID: PMC3286170 - DOI: 10.1634/theoncologist.2011-0321
Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK
Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).
PLoS One. 2012;7(2):e26331 - PMID: 22347360 - PMCID: PMC3274514 - DOI: 10.1371/journal.pone.0026331
Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK
An isolated tumor perfusion model in mice.
Nat Protoc. 2012;7(4):749-55 - PMID: 22441293 - PMCID: PMC3375334 - DOI: 10.1038/nprot.2012.030
Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG
Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
Nat Protoc. 2012;7(4):756-62 - PMID: 22441294 - PMCID: PMC3380105 - DOI: 10.1038/nprot.2012.031
Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D
A transient parabiosis skin transplantation model in mice.
Nat Protoc. 2012;7(4):763-70 - PMID: 22441295 - PMCID: PMC3375333 - DOI: 10.1038/nprot.2012.032
Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D
Multistage nanoparticles for improved delivery into tumor tissue.
Methods Enzymol. 2012;508:109-30 - PMID: 22449923 - PMCID: PMC3774840 - DOI: 10.1016/B978-0-12-391860-4.00006-9
Vakoc BJ, Fukumura D, Jain RK, Bouma BE
Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.
Nat Rev Cancer. 2012;12(5):363-8 - PMID: 22475930 - PMCID: PMC3560400 - DOI: 10.1038/nrc3235
Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Nat Nanotechnol. 2012;7(6):383-8 - PMID: 22484912 - PMCID: PMC3370066 - DOI: 10.1038/nnano.2012.45
Goel S, Fukumura D, Jain RK
Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology.
Proc Natl Acad Sci U S A. 2012;109(20):E1214 - PMID: 22550180 - PMCID: PMC3356659 - DOI: 10.1073/pnas.1203794109
Kozin SV, Duda DG, Munn LL, Jain RK
Neovascularization After Irradiation: What is the Source of Newly Formed Vessels in Recurring Tumors?
J Natl Cancer Inst. 2012;104(12):899-905 - PMID: 22572994 - PMCID: PMC3379722 - DOI: 10.1093/jnci/djs239
Duda DG
Targeting Tumor Angiogenesis: Biomarkers of Angiogenesis and Antiangiogenic Therapy in Cancer
Angiogenesis Foundation CME e-publication. 2011;:ePub
Yoon SS, Duda DG, Karl DL, Kim TM, Kambadakone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M, Sahani DV, Park PJ, Jain RK, Delaney TF
Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas.
Int J Radiat Oncol Biol Phys. 2011;81(4):1081-90 - PMID: 20932656 - PMCID: PMC3021107 - DOI: 10.1016/j.ijrobp.2010.07.024
Van Cutsem E, Lambrechts D, Prenen H, Jain RK, Carmeliet P
Lessons from the adjuvant bevacizumab trial on colon cancer: what next?
J Clin Oncol. 2011;29(1):1-4 - PMID: 21115866 - DOI: 10.1200/JCO.2010.32.2701
Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG
Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.
PLoS One. 2011;6(3):e17228 - PMID: 21390238 - PMCID: PMC3048404 - DOI: 10.1371/journal.pone.0017228
Emblem KE, Bjornerud A, Mouridsen K, Borra RJ, Batchelor TT, Jain RK, Sorensen AG
T(1)- and T(2)(*)-dominant extravasation correction in DSC-MRI: part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients.
J Cereb Blood Flow Metab. 2011;31(10):2054-64 - PMID: 21505476 - PMCID: PMC3208147 - DOI: 10.1038/jcbfm.2011.39
Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG
Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma.
Cancer Res. 2011;71(11):3745-52 - PMID: 21507932 - PMCID: PMC3107375 - DOI: 10.1158/0008-5472.CAN-10-2991
Carmeliet P, Jain RK
Molecular mechanisms and clinical applications of angiogenesis.
Nature. 2011;473(7347):298-307 - PMID: 21593862 - PMCID: PMC4049445 - DOI: 10.1038/nature10144
Carmeliet P, Jain RK
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases.
Nat Rev Drug Discov. 2011;10(6):417-27 - PMID: 21629292 - DOI: 10.1038/nrd3455
Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jain RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM
Cell-surface sensors for real-time probing of cellular environments.
Nat Nanotechnol. 2011;6(8):524-31 - PMID: 21765401 - PMCID: PMC3163485 - DOI: 10.1038/nnano.2011.101
Song JW, Munn LL
Fluid forces control endothelial sprouting.
Proc Natl Acad Sci U S A. 2011;108(37):15342-7 - PMID: 21876168 - PMCID: PMC3174629 - DOI: 10.1073/pnas.1105316108
Faber AC, Corcoran RB, Ebi H, Sequist LV, Waltman BA, Chung E, Incio J, Digumarthy SR, Pollack SF, Song Y, Muzikansky A, Lifshits E, Roberge S, Coffman EJ, Benes CH, Gómez HL, Baselga J, Arteaga CL, Rivera MN, Dias-Santagata D, Jain RK, Engelman JA
BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
Cancer Discov. 2011;1(4):352-65 - PMID: 22145099 - PMCID: PMC3229203 - DOI: 10.1158/2159-8290.CD-11-0106
Jain A, Munn LL
Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip.
Lab Chip. 2011;11(17):2941-7 - PMID: 21773633 - PMCID: PMC3743538 - DOI: 10.1039/c1lc20401g
Huang Y, Snuderl M, Jain RK
Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
Cancer Cell. 2011;19(1):1-2 - PMID: 21251607 - PMCID: PMC3037265 - DOI: 10.1016/j.ccr.2011.01.005
di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK
Glioblastoma recurrence after cediranib therapy in patients: lack of rebound revascularization as mode of escape.
Cancer Res. 2011;71(1):19-28 - PMID: 21199795 - PMCID: PMC3074948 - DOI: 10.1158/0008-5472.CAN-10-2602
Jain RK, Munn LL, Fukumura D, Melder RJ
In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.
Methods Mol Med. 2011;18:553-75 - PMID: 21370203 - DOI: 10.1385/0-89603-516-6:553
Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT
Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
J Neurooncol. 2011;103(2):325-32 - PMID: 20821342 - PMCID: PMC4090923 - DOI: 10.1007/s11060-010-0390-7
Wang E, Feng Y, Zhang M, Zou L, Li Y, Buys ES, Huang P, Brouckaert P, Chao W
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms.
Anesthesiology. 2011;114(3):603-13 - PMID: 21270629 - PMCID: PMC3044772 - DOI: 10.1097/ALN.0b013e31820a4d5b
Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK
Dehydro-alpha-lapachone, a plant product with antivascular activity.
Proc Natl Acad Sci U S A. 2011;108(28):11596-601 - PMID: 21709229 - PMCID: PMC3136298 - DOI: 10.1073/pnas.1104225108
Zhu AX, Duda DG, Ancukiewicz M, di Tomaso E, Clark JW, Miksad R, Fuchs CS, Ryan DP, Jain RK
Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value.
Clin Cancer Res. 2011;17(4):918-27 - PMID: 20843836 - PMCID: PMC3023846 - DOI: 10.1158/1078-0432.CCR-10-0515
Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proc Natl Acad Sci U S A. 2011;108(1):302-7 - PMID: 21173223 - PMCID: PMC3017172 - DOI: 10.1073/pnas.1016917108
Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK
Scaling rules for diffusive drug delivery in tumor and normal tissues.
Proc Natl Acad Sci U S A. 2011;108(5):1799-803 - PMID: 21224417 - PMCID: PMC3033252 - DOI: 10.1073/pnas.1018154108
Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D
Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Proc Natl Acad Sci U S A. 2011;108(6):2426-31 - PMID: 21245339 - PMCID: PMC3038705 - DOI: 10.1073/pnas.1018382108
Liao S, Liu J, Lin P, Shi T, Jain RK, Xu L
TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.
Clin Cancer Res. 2011;17(6):1415-24 - PMID: 21278244 - PMCID: PMC3060297 - DOI: 10.1158/1078-0432.CCR-10-2429
Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Proc Natl Acad Sci U S A. 2011;108(7):2909-14 - PMID: 21282607 - PMCID: PMC3041115 - DOI: 10.1073/pnas.1018892108
Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A. 2011;108(9):3725-30 - PMID: 21321210 - PMCID: PMC3048115 - DOI: 10.1073/pnas.1100446108
Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK
CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Clin Cancer Res. 2011;17(8):2074-80 - PMID: 21349998 - PMCID: PMC3079023 - DOI: 10.1158/1078-0432.CCR-10-2636
Zhu AX, Duda DG, Sahani DV, Jain RK
HCC and angiogenesis: possible targets and future directions.
Nat Rev Clin Oncol. 2011;8(5):292-301 - PMID: 21386818 - PMCID: PMC3266719 - DOI: 10.1038/nrclinonc.2011.30
Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L
PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
Clin Cancer Res. 2011;17(11):3638-48 - PMID: 21459800 - PMCID: PMC3107920 - DOI: 10.1158/1078-0432.CCR-10-2456
Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK
The biology of brain metastases-translation to new therapies.
Nat Rev Clin Oncol. 2011;8(6):344-56 - PMID: 21487419 - PMCID: PMC3259742 - DOI: 10.1038/nrclinonc.2011.58
Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cancer Res. 2011;71(13):4527-38 - PMID: 21571860 - DOI: 10.1158/0008-5472.CAN-10-4376
Kozin SV, Duda DG, Munn LL, Jain RK
Is vasculogenesis crucial for the regrowth of irradiated tumours?
Nat Rev Cancer. 2011;11(7):532 - PMID: 21701514 - PMCID: PMC4790119 - DOI: 10.1038/nrc2007-c1
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Normalization of the vasculature for treatment of cancer and other diseases.
Physiol Rev. 2011;91(3):1071-121 - PMID: 21742796 - PMCID: PMC3258432 - DOI: 10.1152/physrev.00038.2010
Huang P, Westmoreland SV, Jain RK, Fukumura D
Spontaneous nonthymic tumors in SCID mice.
Comp Med. 2011;61(3):227-34 - PMID: 21819692 - PMCID: PMC3123755
Dawson MR, Chae SS, Jain RK, Duda DG
Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
Am J Cancer Res. 2011;1(2):144-54 - PMID: 21822499 - PMCID: PMC3150110
Horowitz NS, Penson RT, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Cohen KS, Berlin S, Krasner CN, Moses MA, Jain RK
Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Clin Ovarian Cancer Other Gynecol Malig. 2011;4(1):26-33 - PMID: 21833345 - PMCID: PMC3151740 - DOI: 10.1016/j.cloc.2011.04.003
Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LL
Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.
Blood. 2011;118(17):4740-9 - PMID: 21835951 - PMCID: PMC3208287 - DOI: 10.1182/blood-2011-02-338426
Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP
Impaired lymphatic contraction associated with immunosuppression.
Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108
Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK
Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.
Angew Chem Int Ed Engl. 2011;50(48):11417-20 - PMID: 22113800 - PMCID: PMC3260125 - DOI: 10.1002/anie.201104449
Jain RK, Munn LL, Fukumura D
Intravital microscopy of normal and diseased tissues in the mouse.
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Xu L, Czito BG, Willett CG
Epigenetic markers in rectal cancer.
Clin Cancer Res. 2010;16(10):2699-701 - PMID: 20460492 - DOI: 10.1158/1078-0432.CCR-10-0559
Duda DG, Ancukiewicz M, Jain RK
Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers?
J Clin Oncol. 2010;28(2):183-5 - PMID: 19949009 - DOI: 10.1200/JCO.2009.24.8021
Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
Science. 2010;327(5965):593-6 - PMID: 20019247 - PMCID: PMC2897160 - DOI: 10.1126/science.1166202
Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG
In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.
Neuro Oncol. 2010;12(4):341-50 - PMID: 20308312 - PMCID: PMC2940602 - DOI: 10.1093/neuonc/nop032
Duda DG, Willett CG, Ancukiewicz M, di Tomaso E, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK
Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.
Oncologist. 2010;15(6):577-83 - PMID: 20484123 - PMCID: PMC3061828 - DOI: 10.1634/theoncologist.2010-0029
Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH
Lymphotoxin-alpha contributes to lymphangiogenesis.
Blood. 2010;116(12):2173-82 - PMID: 20566898 - PMCID: PMC2951858 - DOI: 10.1182/blood-2009-12-256065
Duda DG, Jain RK
Premetastatic lung niche: is vascular endothelial growth factor receptor 1 activation required?
Cancer Res. 2010;70(14):5670-3 - PMID: 20587530 - PMCID: PMC2919170 - DOI: 10.1158/0008-5472.CAN-10-0119
Willett CG, Duda DG, Ancukiewicz M, Shah M, Czito BG, Bentley R, Poleski M, Fujita H, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Chung DC, Clark JW, Jain RK
A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.
Oncologist. 2010;15(8):845-51 - PMID: 20667969 - PMCID: PMC3078712 - DOI: 10.1634/theoncologist.2010-0030
Liao S, Padera TP, Jain RK
Notch leads lymphatics and links them to blood vessels.
Arterioscler Thromb Vasc Biol. 2010;30(9):1682-3 - PMID: 20720193 - PMCID: PMC2945915 - DOI: 10.1161/ATVBAHA.110.210633
Jain RK, Stylianopoulos T
Delivering nanomedicine to solid tumors.
Nat Rev Clin Oncol. 2010;7(11):653-64 - PMID: 20838415 - PMCID: PMC3065247 - DOI: 10.1038/nrclinonc.2010.139
Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG
Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.
Cancer Res. 2010;70(14):5679-85 - PMID: 20631066 - PMCID: PMC2918387 - DOI: 10.1158/0008-5472.CAN-09-4446
Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
J Clin Oncol. 2010;28(17):2817-23 - PMID: 20458050 - PMCID: PMC2903316 - DOI: 10.1200/JCO.2009.26.3988
Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E
Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.
Cancer Res. 2010;70(9):3483-93 - PMID: 20406973 - PMCID: PMC4785015 - DOI: 10.1158/0008-5472.CAN-09-3107
Gerstner ER, Chen PJ, Wen PY, Jain RK, Batchelor TT, Sorensen G
Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib.
Neuro Oncol. 2010;12(5):466-72 - PMID: 20406897 - PMCID: PMC2940624 - DOI: 10.1093/neuonc/nop051
Finn AV, Jain RK
Coronary plaque neovascularization and hemorrhage: a potential target for plaque stabilization?
JACC Cardiovasc Imaging. 2010;3(1):41-4 - PMID: 20129529 - PMCID: PMC2842010 - DOI: 10.1016/j.jcmg.2009.11.001
Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG
InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
J Am Chem Soc. 2010;132(2):470-1 - PMID: 20025222 - PMCID: PMC2862004 - DOI: 10.1021/ja908250r
Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG
Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
J Am Chem Soc. 2010;132(2):472-83 - PMID: 20025223 - PMCID: PMC2871316 - DOI: 10.1021/ja908137d
Choi B, Bouma B, Fukumura D, Jain RK
Optical methods in vascular biology and medicine.
J Biomed Opt. 2010;15(1):011001 - PMID: 20210426 - DOI: 10.1117/1.3338696
Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH
In vivo wide-area cellular imaging by side-view endomicroscopy.
Nat Methods. 2010;7(4):303-5 - PMID: 20228814 - PMCID: PMC2849759 - DOI: 10.1038/nmeth.1440
Fukumura D, Duda DG, Munn LL, Jain RK
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Microcirculation. 2010;17(3):206-25 - PMID: 20374484 - PMCID: PMC2859831 - DOI: 10.1111/j.1549-8719.2010.00029.x
Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D
Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Clin Cancer Res. 2010;16(14):3618-27 - PMID: 20501615 - PMCID: PMC2905497 - DOI: 10.1158/1078-0432.CCR-09-3073
Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL
Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
Nat Methods. 2010;7(8):655-60 - PMID: 20581828 - PMCID: PMC2921873 - DOI: 10.1038/nmeth.1475
Brown E, Munn LL, Fukumura D, Jain RK
In vivo imaging of tumors.
Cold Spring Harb Protoc. 2010;2010(7):pdb.prot5452 - PMID: 20647356 - PMCID: PMC3891051 - DOI: 10.1101/pdb.prot5452
Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK
Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Biophys J. 2010;99(5):1342-9 - PMID: 20816045 - PMCID: PMC2931749 - DOI: 10.1016/j.bpj.2010.06.016
Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG
A nanoparticle size series for in vivo fluorescence imaging.
Angew Chem Int Ed Engl. 2010;49(46):8649-52 - PMID: 20886481 - PMCID: PMC3035057 - DOI: 10.1002/anie.201003142
Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RK
Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
Biophys J. 2010;99(10):3119-28 - PMID: 21081058 - PMCID: PMC2980743 - DOI: 10.1016/j.bpj.2010.08.065
Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK
Malignant cells facilitate lung metastasis by bringing their own soil.
Proc Natl Acad Sci U S A. 2010;107(50):21677-82 - PMID: 21098274 - PMCID: PMC3003109 - DOI: 10.1073/pnas.1016234107
Jain RK, Tam J, Au P, Fukumura D
Angiogenesis in Development, Disease and Regeneration.
In: Santin M, editor. Strategies in Regenerative Medicine: Integrating Biology with Materials Design. Springer, New York. 2009;Chapter 6:ePub
Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT
The potential utility of anti-VEGF agents to normalize tumor vasculature and alleviate edema in brain and spinal cord tumor patients.
Nat Clin Pract Oncol. 2009;6:229-36
Jain RK, Duda DG, Sorensen AG
Emerging paradigms and potential biomarkers of response and resistance in anatiangiogenic therapy of cancer
ASCO 2009 Educational Book. 2009;:716-21
Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK
Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
J Cell Physiol. 2009;219(2):430-7 - PMID: 19170073 - PMCID: PMC2665001 - DOI: 10.1002/jcp.21686
Cheng G, Tse J, Jain RK, Munn LL
Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.
PLoS One. 2009;4(2):e4632 - PMID: 19247489 - PMCID: PMC2645686 - DOI: 10.1371/journal.pone.0004632
Perentes JY, Duda DG, Jain RK
Visualizing anti-tumor immune responses in vivo.
Dis Model Mech. 2009;2(3-4):107-10 - PMID: 19259379 - PMCID: PMC2650205 - DOI: 10.1242/dmm.001842
Wen PY, Yung WK, Lamborn KR, Norden AD, Cloughesy TF, Abrey LE, Fine HA, Chang SM, Robins HI, Fink K, Deangelis LM, Mehta M, Di Tomaso E, Drappatz J, Kesari S, Ligon KL, Aldape K, Jain RK, Stiles CD, Egorin MJ, Prados MD
Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08).
Neuro Oncol. 2009;11(6):853-60 - PMID: 19293394 - PMCID: PMC2802405 - DOI: 10.1215/15228517-2009-010
Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D
Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
Cancer Res. 2009;69(7):2801-8 - PMID: 19318557 - PMCID: PMC2670480 - DOI: 10.1158/0008-5472.CAN-08-4051
Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK
Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
J Clin Oncol. 2009;27(15):2542-52 - PMID: 19332720 - PMCID: PMC2739611 - DOI: 10.1200/JCO.2008.19.9356
Tam J, Duda DG, Perentes JY, Quadri RS, Fukumura D, Jain RK
Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells.
PLoS One. 2009;4(3):e4974 - PMID: 19333381 - PMCID: PMC2659427 - DOI: 10.1371/journal.pone.0004974
Gerstner ER, Sorensen AG, Jain RK, Batchelor TT
Anti-vascular endothelial growth factor therapy for malignant glioma.
Curr Neurol Neurosci Rep. 2009;9(3):254-62 - PMID: 19348715 - PMCID: PMC4790123
di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RK
PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.
PLoS One. 2009;4(4):e5123 - PMID: 19352490 - PMCID: PMC2662415 - DOI: 10.1371/journal.pone.0005123
Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
J Clin Oncol. 2009;27(18):3020-6 - PMID: 19470921 - PMCID: PMC2702234 - DOI: 10.1200/JCO.2008.21.1771
Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG
Biomarkers of response and resistance to antiangiogenic therapy.
Nat Rev Clin Oncol. 2009;6(6):327-38 - PMID: 19483739 - PMCID: PMC3057433 - DOI: 10.1038/nrclinonc.2009.63
Jain RK
A new target for tumor therapy.
N Engl J Med. 2009;360(25):2669-71 - PMID: 19535806 - PMCID: PMC4792114 - DOI: 10.1056/NEJMcibr0902054
Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y
Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.
Int J Radiat Oncol Biol Phys. 2009;74(5):1580-91 - PMID: 19540073 - DOI: 10.1016/j.ijrobp.2009.03.047
Sorensen AG, Batchelor TT, Zhang WT, Chen PJ, Yeo P, Wang M, Jennings D, Wen PY, Lahdenranta J, Ancukiewicz M, di Tomaso E, Duda DG, Jain RK
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.
Cancer Res. 2009;69(13):5296-300 - PMID: 19549889 - PMCID: PMC2824172 - DOI: 10.1158/0008-5472.CAN-09-0814
Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA
Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast.
Opt Lett. 2009;34(13):2066-8 - PMID: 19572001 - PMCID: PMC2872111
Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK
Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Biophys J. 2009;97(1):330-6 - PMID: 19580771 - PMCID: PMC2711376 - DOI: 10.1016/j.bpj.2009.03.064
Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
N Engl J Med. 2009;361(4):358-67 - PMID: 19587327 - PMCID: PMC4816642 - DOI: 10.1056/NEJMoa0902579
Jain A, Munn LL
Determinants of leukocyte margination in rectangular microchannels.
PLoS One. 2009;4(9):e7104 - PMID: 19768109 - PMCID: PMC2740820 - DOI: 10.1371/journal.pone.0007104
Zhu AX, Duda DG, Sahani DV, Jain RK
Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.
Cancer J. 2009;15(4):263-8 - PMID: 19672141 - PMCID: PMC4792519 - DOI: 10.1097/PPO.0b013e3181af5e35
Chi AS, Sorensen AG, Jain RK, Batchelor TT
Angiogenesis as a therapeutic target in malignant gliomas.
Oncologist. 2009;14(6):621-36 - PMID: 19487335 - PMCID: PMC4790121 - DOI: 10.1634/theoncologist.2008-0272
Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK
Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo.
Am J Pathol. 2009;175(1):294-302 - PMID: 19477947 - PMCID: PMC2708815 - DOI: 10.2353/ajpath.2009.080887
Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
J Clin Oncol. 2009;27(18):3027-35 - PMID: 19470923 - PMCID: PMC2702235 - DOI: 10.1200/JCO.2008.20.9908
Jones R, Capen DE, Jacobson M, Cohen KS, Scadden DT, Duda DG
VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI).
J Cell Mol Med. 2009;13(9B):3720-9 - PMID: 19426150 - PMCID: PMC2832073 - DOI: 10.1111/j.1582-4934.2009.00785.x
Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT
VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer.
Nat Rev Clin Oncol. 2009;6(4):229-36 - PMID: 19333229 - PMCID: PMC4793889 - DOI: 10.1038/nrclinonc.2009.14
Mok W, Stylianopoulos T, Boucher Y, Jain RK
Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.
Clin Cancer Res. 2009;15(7):2352-60 - PMID: 19318482 - PMCID: PMC2872130 - DOI: 10.1158/1078-0432.CCR-08-2082
Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nat Methods. 2009;6(2):143-5 - PMID: 19151720 - PMCID: PMC2877598 - DOI: 10.1038/nmeth.1295
Tam J, Fukumura D, Jain RK
A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.
Cell Metab. 2009;9(1):52-63 - PMID: 19117546 - PMCID: PMC2643084 - DOI: 10.1016/j.cmet.2008.11.005
Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971
Dawson MR, Duda DG, Fukumura D, Jain RK
VEGFR1-activity-independent metastasis formation.
Nature. 2009;461(7262):E4; discussion E5 - PMID: 19759568 - PMCID: PMC3065241 - DOI: 10.1038/nature08254
Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK
VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
PLoS One. 2009;4(9):e6525 - PMID: 19763275 - PMCID: PMC2744279 - DOI: 10.1371/journal.pone.0006525
Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK
Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Cancer Res. 2009;69(20):7905-10 - PMID: 19826039 - PMCID: PMC2859041 - DOI: 10.1158/0008-5472.CAN-09-2099
Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK
Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
PLoS One. 2009;4(12):e8316 - PMID: 20016816 - PMCID: PMC2789383 - DOI: 10.1371/journal.pone.0008316
Willett CG, Duda DG, Xu L, diTomaso E, Boucher Y, Czito B, Ancukiewicz M, Clark J, Carroll M, Lauwers G, Jain RK
Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC).
J Clin Oncol. 2008;26(15_suppl):4096 - PMID: 27949464
Jain RK, Duda DG, Batchelor TT, Sorensen AG, Willett CG
Normalization of tumor vasculature and microenvironment.
In: Angiogenesis: An Integrative Approach from Science to Medicine (Editors: W. D. Figg and J. Folkman), Springer. 2008;:173-282
Jain RK, Duda DG
Vascular and interstitial biology of tumors
In: Clinical Oncology. 4th Edition, (Editors: Abeloff M, Armitage J, Niederhuber J, Kastan M, McKenna WG), Elsevier, Philadelphia. 2008;:105-24
Jain RK, Kozak K
Molecular Pathophysiology of Tumors.
In: Principles and Practice of Radiation Oncology, 5th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2008;Chapter 4:126-141
Jain RK, Booth MF, Padera TP, Munn LL, Fukumura D, Brown E
Applications of nonlinear intravital microscopy in tumor biology.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 29:735-756
Brown E, Majewska A, Jain RK
Photobleaching and recovery with nonlinear microscopy.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 26:673-688
Jain RK
Judah Folkman
Journal of Clinical Investigation. 2008;118:823
Kozin SV, Niemierko A, Huang P, Silva J, Doppke KP, Suit HD
Inter- and intramouse heterogeneity of radiation response for a growing paired organ.
Radiat Res. 2008;170(2):264-7 - PMID: 18666813 - DOI: 10.1667/RR1262.1
Jain RK, Lahdenranta J, Fukumura D
Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
PLoS Med. 2008;5(1):e24 - PMID: 18232729 - PMCID: PMC2214795 - DOI: 10.1371/journal.pmed.0050024
Sun C, Munn LL
Lattice Boltzmann simulation of blood flow in digitized vessel networks.
Comput Math Appl. 2008;55(7):1594-1600 - PMID: 19343080 - PMCID: PMC2390865 - DOI: 10.1016/j.camwa.2007.08.019
Gerstner ER, Sorensen AG, Jain RK, Batchelor TT
Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.
Curr Opin Neurol. 2008;21(6):728-35 - PMID: 18989120 - DOI: 10.1097/WCO.0b013e328318402a
Fukumura D, Jain RK
Imaging angiogenesis and the microenvironment.
APMIS. 2008;116(7-8):695-715 - PMID: 18834413 - PMCID: PMC2859845 - DOI: 10.1111/j.1600-0463.2008.01148.x
Sorensen AG, Batchelor TT, Wen PY, Zhang WT, Jain RK
Response criteria for glioma.
Nat Clin Pract Oncol. 2008;5(11):634-44 - PMID: 18711427 - PMCID: PMC4795821 - DOI: 10.1038/ncponc1204
Padera TP, Jain RK
VEGFR3: a new target for antiangiogenesis therapy?
Dev Cell. 2008;15(2):178-9 - PMID: 18694556 - PMCID: PMC4790102 - DOI: 10.1016/j.devcel.2008.07.014
Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK
Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182
Huang P, Duda DG, Jain RK, Fukumura D
Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079
Nagano S, Perentes JY, Jain RK, Boucher Y
Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer Res. 2008;68(10):3795-802 - PMID: 18483263 - PMCID: PMC2871708 - DOI: 10.1158/0008-5472.CAN-07-6193
Jain RK
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.
Nat Rev Cancer. 2008;8(4):309-16 - PMID: 18337733 - DOI: 10.1038/nrc2346
Jones RC, Capen DE, Cohen KS, Munn LL, Jain RK, Duda DG
A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):388-97 - PMID: 18323810 - PMCID: PMC2676340 - DOI: 10.1038/nprot.2007.537
Jones RC, Capen D, Petersen B, Jain RK, Duda DG
A protocol for a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):378-87 - PMID: 18323809 - PMCID: PMC2676330 - DOI: 10.1038/nprot.2007.536
Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D
Perivascular nitric oxide gradients normalize tumor vasculature.
Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730
Au P, Tam J, Fukumura D, Jain RK
Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.
Blood. 2008;111(9):4551-8 - PMID: 18256324 - PMCID: PMC2343592 - DOI: 10.1182/blood-2007-10-118273
Jain RK
Taming vessels to treat cancer.
Sci Am. 2008;298(1):56-63 - PMID: 18225696
Munn LL, Dupin MM
Blood cell interactions and segregation in flow.
Ann Biomed Eng. 2008;36(4):534-44 - PMID: 18188702 - PMCID: PMC2752714 - DOI: 10.1007/s10439-007-9429-0
Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.
Blood. 2008;111(3):1302-5 - PMID: 17993613 - PMCID: PMC2214740 - DOI: 10.1182/blood-2007-06-094318
Jain RK, Fukumura D, Munn LL, Brown E
Tumor Angiogenesis and Blood Flow.
In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:199-201
Jain RK, Fukumura D, Munn LL, Brown E
Optical Microscopy in Small Animal Research
In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:183-187
Jain RK, Batchelor TT, Duda DG, Willett CG
Normalization of tumor vasculature and microenvironment.
In: Antiangiogenic Agents in Cancer Therapy. (Editors: Beverly Teicher and Lee Ellis), Humana Press. 2007;:261-76
Jain RK, Duda DG
Normalization of tumor vasculature and microenvironment by antiangiogenic therapy.
In: Angiogenesis: Mechanisms and Cancer Therapy (Editors: Dieter Marm and Norbert E. Fusenig), Springer-Verlag, Berlin. 2007;:577-92
Jain RK, Duda DG
Angiogenesis in Solid Tumors
In: Antiangiogenic Cancer Therapy (Editors: James L. Abbruzzese, Darren W. Davis and Roy S. Herbst), CRC Press, Boca Raton. 2007;:43-90
Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK
Data do not support benefits of anti-VEGFR3 therapy
Cancer Research. 2007;67:5055
Willett CG, Duda DG, Jain RK
Surrogate biomarkers for anti-angiogenic therapy for advanced colorectal cancer.
Current Colorectal Cancer Reports. 2007;3:94-98
Jain RK, Munn LL
Vascular normalization as rationale for combining chemotherapy with antiangiogenic agents
PPO Updates. 2007;21:1-7
Duda DG, Cohen KS, Au P, Scadden DT, Willett CG, Jain RK
Detection of circulating endothelial cells: CD146- based magnetic separation enrichment or flow cytometric assay?
J Clin Oncol. 2007;25:e3-e5
Duda DG
Endothelial cell-based therapy for hematopoiesis
Blood. 2007;109(6):2272-3
Fukumura D, Jain RK
Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.
J Cell Biochem. 2007;101(4):937-49 - PMID: 17171643 - DOI: 10.1002/jcb.21187
Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Cancer Cell. 2007;11(1):83-95 - PMID: 17222792 - PMCID: PMC2748664 - DOI: 10.1016/j.ccr.2006.11.021
Tyrrell JA, di Tomaso E, Fuja D, Tong R, Kozak K, Jain RK, Roysam B
Robust 3-D modeling of vasculature imagery using superellipsoids.
IEEE Trans Med Imaging. 2007;26(2):223-37 - PMID: 17304736 - DOI: 10.1109/TMI.2006.889722
Jain RK, Tong RT, Munn LL
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.
Cancer Res. 2007;67(6):2729-35 - PMID: 17363594 - PMCID: PMC3022341 - DOI: 10.1158/0008-5472.CAN-06-4102
Duda DG, Cohen KS, Scadden DT, Jain RK
A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.
Nat Protoc. 2007;2(4):805-10 - PMID: 17446880 - PMCID: PMC2686125 - DOI: 10.1038/nprot.2007.111
Bockhorn M, Jain RK, Munn LL
Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
Lancet Oncol. 2007;8(5):444-8 - PMID: 17466902 - PMCID: PMC2712886 - DOI: 10.1016/S1470-2045(07)70140-7
Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE
Influence of tumor cell and stroma sensitivity on tumor response to radiation.
Cancer Res. 2007;67(9):4016-21 - PMID: 17483312 - DOI: 10.1158/0008-5472.CAN-06-4498
Fukumura D, Jain RK
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.
Microvasc Res. 2007;74(2-3):72-84 - PMID: 17560615 - PMCID: PMC2100036 - DOI: 10.1016/j.mvr.2007.05.003
Duda DG
American Association for Cancer Research 98th Annual Meeting. Angiogenesis and anti-angiogenesis in cancer.
IDrugs. 2007;10(6):366-9 - PMID: 17641996
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT
Angiogenesis in brain tumours.
Nat Rev Neurosci. 2007;8(8):610-22 - PMID: 17643088 - DOI: 10.1038/nrn2175
Jain RK, Finn AV, Kolodgie FD, Gold HK, Virmani R
Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization.
Nat Clin Pract Cardiovasc Med. 2007;4(9):491-502 - PMID: 17712362 - DOI: 10.1038/ncpcardio0979
Au P, Tam J, Fukumura D, Jain RK
Small blood vessel engineering.
Methods Mol Med. 2007;140:183-95 - PMID: 18085210
Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK
Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938
Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT
Antiangiogenic agents for the treatment of glioblastoma.
Expert Opin Investig Drugs. 2007;16(12):1895-908 - PMID: 18041999 - DOI: 10.1517/13543784.16.12.1895
Mok W, Boucher Y, Jain RK
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107
Jain RK, Xu L
alphaPlGF: a new kid on the antiangiogenesis block.
Cell. 2007;131(3):443-5 - PMID: 17981110 - DOI: 10.1016/j.cell.2007.10.023
Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK
Targeted therapy in rectal cancer.
Oncology (Williston Park). 2007;21(9):1055-65 - PMID: 17910311 - PMCID: PMC2686129
Sun C, Jain RK, Munn LL
Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.
Ann Biomed Eng. 2007;35(12):2121-9 - PMID: 17846892 - PMCID: PMC2752713 - DOI: 10.1007/s10439-007-9377-8
Duda DG, Jain RK, Willett CG
Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.
J Clin Oncol. 2007;25(26):4033-42 - PMID: 17827451 - PMCID: PMC2686120 - DOI: 10.1200/JCO.2007.11.3985
Xu L, Jain RK
Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma.
Mol Cancer Res. 2007;5(9):873-80 - PMID: 17704140 - DOI: 10.1158/1541-7786.MCR-06-0141
Dupin MM, Halliday I, Care CM, Alboul L, Munn LL
Modeling the flow of dense suspensions of deformable particles in three dimensions.
Phys Rev E Stat Nonlin Soft Matter Phys. 2007;75(6 Pt 2):066707 - PMID: 17677389 - PMCID: PMC2752716 - DOI: 10.1103/PhysRevE.75.066707
Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y
Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.
Cancer Res. 2007;67(11):5076-82 - PMID: 17545583 - DOI: 10.1158/0008-5472.CAN-06-3664
Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK
Anti-VEGFR-3 therapy and lymph node metastasis [corrected].
Cancer Res. 2007;67(10):5055; author reply 5056 - PMID: 17510438 - DOI: 10.1158/0008-5472.CAN-06-2935
Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK
Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.
Nat Clin Pract Oncol. 2007;4(5):316-21 - PMID: 17464339 - PMCID: PMC2686127 - DOI: 10.1038/ncponc0813
Duda DG, Batchelor TT, Willett CG, Jain RK
VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects.
Trends Mol Med. 2007;13(6):223-30 - PMID: 17462954 - PMCID: PMC2686126 - DOI: 10.1016/j.molmed.2007.04.001
Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.
Nat Biotechnol. 2007;25(3):317-8 - PMID: 17322871 - DOI: 10.1038/nbt1287
Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB
Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma.
J Soc Integr Oncol. 2007;5(1):11-7 - PMID: 17309809 - DOI: 10.2310/7200.2006.033
Saito Y, Sunamura M, Motoi F, Abe H, Egawa S, Duda DG, Hoshida T, Fukuyama S, Hamada H, Matsuno S
Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region.
Cancer Gene Ther. 2006;13(3):242-52 - PMID: 16179928 - DOI: 10.1038/sj.cgt.7700902
Jones R, Capen D, Jacobson M, Munn L
PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension.
Cell Tissue Res. 2006;326(3):759-69 - PMID: 16794827 - DOI: 10.1007/s00441-006-0177-5
Jain RK
Seminal findings and an allergy to black flies.
In: Reflections from the Frontiers, Explorations for the Future: Gordon Research Conferences, 1931-2006 (Editors: Arthur A. Daemmrich, Nancy Ryan Gray and Leah Shaper), Gordon Research Conferences and Chemical Heritage Foundation, Philadelphia. 2006;:70-71
Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK
Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
Blood. 2006;107(7):2774-6 - PMID: 16339405 - PMCID: PMC1895376 - DOI: 10.1182/blood-2005-08-3210
Jain RK, Duda DG, Clark JW, Loeffler JS
Lessons from phase III clinical trials on anti-VEGF therapy for cancer.
Nat Clin Pract Oncol. 2006;3(1):24-40 - PMID: 16407877 - DOI: 10.1038/ncponc0403
Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Proc Natl Acad Sci U S A. 2006;103(4):855-60 - PMID: 16418262 - PMCID: PMC1348013 - DOI: 10.1073/pnas.0510412103
McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Cancer Res. 2006;66(5):2509-13 - PMID: 16510565 - DOI: 10.1158/0008-5472.CAN-05-2242
Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK
Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
J Clin Oncol. 2006;24(9):1449-53 - PMID: 16549839 - PMCID: PMC2718681 - DOI: 10.1200/JCO.2005.04.2861
Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK
Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer Res. 2006;66(7):3360-4 - PMID: 16585153 - DOI: 10.1158/0008-5472.CAN-05-2655
Duda DG
Antiangiogenesis and drug delivery to tumors: bench to bedside and back.
Cancer Res. 2006;66(8):3967-70 - PMID: 16618712 - DOI: 10.1158/0008-5472.CAN-05-4536
Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D
Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.
Cancer Res. 2006;66(8):3971-7 - PMID: 16618713 - DOI: 10.1158/0008-5472.CAN-04-3085
Reddy ST, Berk DA, Jain RK, Swartz MA
A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.
J Appl Physiol. 2006;101(4):1162-9 - PMID: 16763103 - DOI: 10.1152/japplphysiol.00389.2006
Hoon DS, Kitago M, Kim J, Mori T, Piris A, Szyfelbein K, Mihm MC, Nathanson SD, Padera TP, Chambers AF, Vantyghem SA, MacDonald IC, Shivers SC, Alsarraj M, Reintgen DS, Passlick B, Sienel W, Pantel K
Molecular mechanisms of metastasis.
Cancer Metastasis Rev. 2006;25(2):203-20 - PMID: 16770533 - DOI: 10.1007/s10555-006-8500-x
Fukumura D, Kashiwagi S, Jain RK
The role of nitric oxide in tumour progression.
Nat Rev Cancer. 2006;6(7):521-34 - PMID: 16794635 - DOI: 10.1038/nrc1910
Cochran DM, Fukumura D, Ancukiewicz M, Carmeliet P, Jain RK
Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.
Ann Biomed Eng. 2006;34(8):1247-58 - PMID: 16832606 - DOI: 10.1007/s10439-006-9134-4
Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK
Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Cancer Res. 2006;66(16):8065-75 - PMID: 16912183 - DOI: 10.1158/0008-5472.CAN-06-1392
Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, Delaney TF, Gaissert HA, Pearce J, Rosenberg AE, Jain RK, Ebb DH
Platelet-derived growth factor receptor-beta in Gorham's disease.
Nat Clin Pract Oncol. 2006;3(12):693-7 - PMID: 17139320 - PMCID: PMC2693369 - DOI: 10.1038/ncponc0660
Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK
Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Semin Oncol. 2006;33(5 Suppl 10):S35-40 - PMID: 17145523 - PMCID: PMC2686124 - DOI: 10.1053/j.seminoncol.2006.08.007
Brown EB, Munn LL, Fukumura D, Jain RK
A Practical Guide to in vivo Imaging of Tumors.
In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 92:695-700
Brown E, Majewska A, Jain RK
FRAP and Multiphoton FRAP.
In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 56:429-438
Sun C, Munn LL
Particulate nature of blood determines macroscopic rheology: a 2-D lattice Boltzmann analysis.
Biophys J. 2005;88(3):1635-45 - PMID: 15613630 - PMCID: PMC1305220 - DOI: 10.1529/biophysj.104.051151
Jain RK
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
Science. 2005;307(5706):58-62 - PMID: 15637262 - DOI: 10.1126/science.1104819
Shevkoplyas SS, Yoshida T, Munn LL, Bitensky MW
Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device.
Anal Chem. 2005;77(3):933-7 - PMID: 15679363 - PMCID: PMC3022340 - DOI: 10.1021/ac049037i
Garkavtsev I, Boucher Y
An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol.
Cancer Biol Ther. 2005;4(1):48-9 - PMID: 15711122
Duda DG, Jain RK
Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.
J Clin Invest. 2005;115(3):596-8 - PMID: 15765145 - PMCID: PMC1052004 - DOI: 10.1172/JCI24511
Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, Molokhia P, Attia K, Sullivan T, Kuter I, Boucher Y, Powell SN
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.
J Clin Oncol. 2005;23(9):1951-61 - PMID: 15774788 - DOI: 10.1200/JCO.2005.08.119
Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Nat Med. 2005;11(6):678-82 - PMID: 15880117 - PMCID: PMC2686110 - DOI: 10.1038/nm1247
Jain RK
Antiangiogenic therapy for cancer: current and emerging concepts.
Oncology (Williston Park). 2005;19(4 Suppl 3):7-16 - PMID: 15934498
Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D
NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
J Clin Invest. 2005;115(7):1816-27 - PMID: 15951843 - PMCID: PMC1143589 - DOI: 10.1172/JCI24015
Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer Res. 2005;65(13):5674-82 - PMID: 15994941 - DOI: 10.1158/0008-5472.CAN-04-1682
Xu L, Tong R, Cochran DM, Jain RK
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Cancer Res. 2005;65(13):5711-9 - PMID: 15994946 - DOI: 10.1158/0008-5472.CAN-04-4313
di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL
Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
Cancer Res. 2005;65(13):5740-9 - PMID: 15994949 - DOI: 10.1158/0008-5472.CAN-04-4552
Jain RK, Au P, Tam J, Duda DG, Fukumura D
Engineering vascularized tissue.
Nat Biotechnol. 2005;23(7):821-3 - PMID: 16003365 - DOI: 10.1038/nbt0705-821
Huang P, McKee TD, Jain RK, Fukumura D
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comp Med. 2005;55(3):236-43 - PMID: 16089171
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer Cell. 2005;8(2):131-41 - PMID: 16098466 - DOI: 10.1016/j.ccr.2005.07.003
Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Héligon C, Terclavers S, Ciesiolka M, Kälin R, Man WY, Senn I, Wyns S, Lupu F, Brändli A, Vleminckx K, Collen D, Dewerchin M, Conway EM, Moons L, Jain RK, Carmeliet P
A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Nat Med. 2005;11(9):998-1004 - PMID: 16116431 - DOI: 10.1038/nm1285
Hagendoorn J, Padera TP, Fukumura D, Jain RK
Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Trends Cardiovasc Med. 2005;15(5):169-73 - PMID: 16165013 - DOI: 10.1016/j.tcm.2005.06.003
Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B
A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.
Microvasc Res. 2005;70(3):165-78 - PMID: 16239015 - DOI: 10.1016/j.mvr.2005.08.005
Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
J Clin Oncol. 2005;23(31):8136-9 - PMID: 16258121 - DOI: 10.1200/JCO.2005.02.5635
Jain RK
Vascular and Interstitial Biology of Tumors.
In: Clinical Oncology, 3rd Edition (Editors: M. Abeleff, J. Armitage, J. Niederhuber, M. Kastan and G. McKenna), Elsevier, Philadelphia, PA. 2004;Chapter 9:153-172
Jain RK, Brown EB, Munn LL, Fukumura D
Intravital microscopy of normal and diseased tissues in the mouse.
In: Live Cell Imaging: A Laboratory Manual (Editors: R. D. Goldman and D. L. Spector). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 2004;Chapter 24:435-466
Jain RK
Correspondence: Recognition of tumor blood vessel normalization as a new antiangiogenic concept.
Nature Medicine. 2004;10:329-330
Chan YT, Zimmer JP, Stroh M, Steckel JS, Jain RK, Bawendi MG
Incorporation of luminescent nanocrystals into monodisperse core-shell silica microspheres.
Advanced Materials. 2004;16:23-24
Willett CG, Duda DG, Fischman A, Jain RK
Correspondence: PET concerns in bevacizumab treatment
Nature Medicine. 2004;10:561
Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Nat Med. 2004;10(2):203-7 - PMID: 14716306 - DOI: 10.1038/nm981
Xu L, Pathak PS, Fukumura D
Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells.
Clin Cancer Res. 2004;10(2):701-7 - PMID: 14760093
Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK
Pathology: cancer cells compress intratumour vessels.
Nature. 2004;427(6976):695 - PMID: 14973470 - DOI: 10.1038/427695a
Gohongi T, Todoroki T, Fukumura D, Jain RK
Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.
Oncol Rep. 2004;11(4):803-7 - PMID: 15010876
Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK
Tissue engineering: creation of long-lasting blood vessels.
Nature. 2004;428(6979):138-9 - PMID: 15014486 - DOI: 10.1038/428138a
Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
Nature. 2004;428(6980):328-32 - PMID: 15029197 - DOI: 10.1038/nature02329
Bockhorn M, Roberge S, Sousa C, Jain RK, Munn LL
Differential gene expression in metastasizing cells shed from kidney tumors.
Cancer Res. 2004;64(7):2469-73 - PMID: 15059900
Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S
The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.
Pancreas. 2004;28(3):311-6 - PMID: 15084978
Brown EB, Boucher Y, Nasser S, Jain RK
Measurement of macromolecular diffusion coefficients in human tumors.
Microvasc Res. 2004;67(3):231-6 - PMID: 15121448 - DOI: 10.1016/j.mvr.2004.02.001
Duda DG, Fukumura D, Jain RK
Role of eNOS in neovascularization: NO for endothelial progenitor cells.
Trends Mol Med. 2004;10(4):143-5 - PMID: 15162796
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.
Cancer Res. 2004;64(11):3731-6 - PMID: 15172975 - DOI: 10.1158/0008-5472.CAN-04-0074
Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK
Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Cancer Res. 2004;64(13):4400-4 - PMID: 15231646 - DOI: 10.1158/0008-5472.CAN-04-0752
Jain RK, Stroh M
Zooming in and out with quantum dots.
Nat Biotechnol. 2004;22(8):959-60 - PMID: 15286644 - DOI: 10.1038/nbt0804-959
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Cancer Cell. 2004;6(6):553-63 - PMID: 15607960 - DOI: 10.1016/j.ccr.2004.10.011
Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK
Differential transplantability of tumor-associated stromal cells.
Cancer Res. 2004;64(17):5920-4 - PMID: 15342367 - DOI: 10.1158/0008-5472.CAN-04-1268
Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK
Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.
Circ Res. 2004;95(2):204-9 - PMID: 15192027 - DOI: 10.1161/01.RES.0000135549.72828.24
Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Nat Med. 2004;10(2):145-7 - PMID: 14745444 - PMCID: PMC2693485 - DOI: 10.1038/nm988
Fidler IJ, Yoneda J, Herrera C, Wood J, Xu L
Specific keynote: molecular determinants of angiogenesis in ovarian cancer.
Gynecol Oncol. 2003;88(1 Pt 2):S29-36; discussion S37-42 - PMID: 12586082
Friedrich EB, Tager AM, Liu E, Pettersson A, Owman C, Munn L, Luster AD, Gerszten RE
Mechanisms of leukotriene B4--triggered monocyte adhesion.
Arterioscler Thromb Vasc Biol. 2003;23(10):1761-7 - PMID: 12947016 - DOI: 10.1161/01.ATV.0000092941.77774.3C
Jain RK
Molecular Pathophysiology of Tumors
In: Principles and Practice of Radiation Oncology, 4th Edition (Editors: C. A. Parez, L. W. Brady, E. C. Halperin, and R. Schmidt-Ullrich), Lippincott, Williams & Wilkins, New York. 2003;Chapter 4:163-179
Netti PA, Jain RK
Interstitial Transport in Solid Tumors
In: Cancer Modeling and Simulation (Editor: L Preziosi), Chapman & Hall, Boca Raton, FL. 2003;Chapter 3:51-74
Netti PA, Travascio F, Jain RK
Coupled Macromolecular Transport and Gel Mechanics: Poroviscoelastic Approach.
AIChE Journal. 2003;49:1580-1596
Jain RK
Angiogenesis and lymphangiogenesis in tumors: insights from intravital microscopy.
Cold Spring Harb Symp Quant Biol. 2003;67:239-48 - PMID: 12858546
Fidler IJ, Yoneda J, Herrera C, Wood J, Xu L
Specific Keynote: Molecular determinants of angiogenesis in ovarian cancer
Gynecologic Oncology. 2003;88:S290S36
Mollica F, Jain RK, Netti PA
A model for temporal heterogeneities of tumor blood flow.
Microvasc Res. 2003;65(1):56-60 - PMID: 12535873
Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD
Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Cancer Res. 2003;63(4):747-51 - PMID: 12591719
Dolmans DE, Fukumura D, Jain RK
Photodynamic therapy for cancer.
Nat Rev Cancer. 2003;3(5):380-7 - PMID: 12724736 - DOI: 10.1038/nrc1071
Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Nat Med. 2003;9(6):796-800 - PMID: 12754503 - DOI: 10.1038/nm879
Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RK
A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.
Blood. 2003;102(7):2555-61 - PMID: 12775571 - DOI: 10.1182/blood-2003-02-0365
Jain RK
Molecular regulation of vessel maturation.
Nat Med. 2003;9(6):685-93 - PMID: 12778167 - DOI: 10.1038/nm0603-685
Jain RK, Duda DG
Role of bone marrow-derived cells in tumor angiogenesis and treatment.
Cancer Cell. 2003;3(6):515-6 - PMID: 12842078
Padera TP, Stoll BR, So PT, Jain RK
Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.
Mol Imaging. 2003;1(1):9-15 - PMID: 12920856
Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B
Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.
Microvasc Res. 2003;66(2):113-25 - PMID: 12935769
Forbes NS, Munn LL, Fukumura D, Jain RK
Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Cancer Res. 2003;63(17):5188-93 - PMID: 14500342
Sunamura M, Duda DG, Ghattas MH, Lozonschi L, Motoi F, Yamauchi J, Matsuno S, Shibahara S, Abraham NG
Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.
Angiogenesis. 2003;6(1):15-24 - PMID: 14517400
Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D
Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts.
Clin Cancer Res. 2003;9(11):4221-6 - PMID: 14519649
Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK
Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.
Circ Res. 2003;93(9):e88-97 - PMID: 14525808 - PMCID: PMC2755542 - DOI: 10.1161/01.RES.0000099243.20096.FA
Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, Abe T, Inoue H, Motoi F, Egawa S, Matsuno S, Horii A
Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.
Oncogene. 2003;22(44):6857-64 - PMID: 14534532 - DOI: 10.1038/sj.onc.1206751
Jain RK, Booth MF
What brings pericytes to tumor vessels?
J Clin Invest. 2003;112(8):1134-6 - PMID: 14561696 - PMCID: PMC213497 - DOI: 10.1172/JCI20087
Roose T, Netti PA, Munn LL, Boucher Y, Jain RK
Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled.
Microvasc Res. 2003;66(3):204-12 - PMID: 14609526
Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.
Clin Cancer Res. 2003;9(15):5508-13 - PMID: 14654530
Padera TP, Boucher Y, Jain RK
Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Cancer Res. 2003;63(23):8555-6; author reply 8558 - PMID: 14679026
Sun C, Migliorini C, Munn LL
Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis.
Biophys J. 2003;85(1):208-22 - PMID: 12829477 - PMCID: PMC1303078 - DOI: 10.1016/S0006-3495(03)74467-1
Munn LL
Aberrant vascular architecture in tumors and its importance in drug-based therapies.
Drug Discov Today. 2003;8(9):396-403 - PMID: 12706657 - DOI: 10.1016/s1359-6446(03)02686-2
Jain RK, Padera TP
Development. Lymphatics make the break.
Science. 2003;299(5604):209-10 - PMID: 12522236 - DOI: 10.1126/science.1081345
Davies Cde L, Berk DA, Pluen A, Jain RK
Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.
Br J Cancer. 2002;86(10):1639-44 - PMID: 12085216 - PMCID: PMC2746604 - DOI: 10.1038/sj.bjc.6600270
Herrera CA, Xu L, Bucana CD, Silva el VG, Hess KR, Gershenson DM, Fidler IJ
Expression of metastasis-related genes in human epithelial ovarian tumors.
Int J Oncol. 2002;20(1):5-13 - PMID: 11743636
Sunamura M, Yatsuoka T, Motoi F, Duda DG, Kimura M, Abe T, Yokoyama T, Inoue H, Oonuma M, Takeda K, Matsuno S
Gene therapy for pancreatic cancer based on genetic characterization of the disease.
J Hepatobiliary Pancreat Surg. 2002;9(1):32-8 - PMID: 12021895 - DOI: 10.1007/s005340200002
Lefter LP, Furukawa T, Sunamura M, Duda DG, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A
Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.
Genes Chromosomes Cancer. 2002;34(2):234-42 - PMID: 11979557 - DOI: 10.1002/gcc.10060
Xu L, Fukumura D, Jain RK
Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF.
J Biol Chem. 2002;277(13):11368-74 - PMID: 11741977 - DOI: 10.1074/jbc.M108347200
Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.
Am J Pathol. 2002;160(3):985-1000 - PMID: 11891196 - PMCID: PMC1867175 - DOI: 10.1016/S0002-9440(10)64920-6
Jain RK, Fenton BT
Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
J Natl Cancer Inst. 2002;94(6):417-21 - PMID: 11904313
Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK
Tumour biology: herceptin acts as an anti-angiogenic cocktail.
Nature. 2002;416(6878):279-80 - PMID: 11907566 - DOI: 10.1038/416279b
Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.
Neoplasia. 2002;4(1):3-8 - PMID: 11922388 - PMCID: PMC1503314 - DOI: 10.1038/sj/neo/7900209
Dolmans DE, Kadambi A, Hill JS, Waters CA, Robinson BC, Walker JP, Fukumura D, Jain RK
Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Cancer Res. 2002;62(7):2151-6 - PMID: 11929837
Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK
Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.
Clin Cancer Res. 2002;8(4):1008-13 - PMID: 11948107
Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
Clin Cancer Res. 2002;8(4):1284-91 - PMID: 11948144
Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK
Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
Br J Cancer. 2002;86(6):947-53 - PMID: 11953828 - PMCID: PMC2364140 - DOI: 10.1038/sj.bjc.6600158
Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK
Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science. 2002;296(5574):1883-6 - PMID: 11976409 - DOI: 10.1126/science.1071420
Jain RK, Munn LL, Fukumura D
Dissecting tumour pathophysiology using intravital microscopy.
Nat Rev Cancer. 2002;2(4):266-76 - PMID: 12001988 - DOI: 10.1038/nrc778
Jain RK, Padera TP
Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy.
J Natl Cancer Inst. 2002;94(11):785-7 - PMID: 12048260
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett. 2002;524(1-3):163-71 - PMID: 12135761
Hoshida T, Sunamura M, Duda DG, Egawa S, Miyazaki S, Shineha R, Hamada H, Ohtani H, Satomi S, Matsuno S
Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor.
Pancreas. 2002;25(2):111-21 - PMID: 12142732
Dolmans DE, Kadambi A, Hill JS, Flores KR, Gerber JN, Walker JP, Borel Rinkes IH, Jain RK, Fukumura D
Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.
Cancer Res. 2002;62(15):4289-94 - PMID: 12154031
Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Biophys J. 2002;83(3):1650-60 - PMID: 12202388 - PMCID: PMC1302261 - DOI: 10.1016/S0006-3495(02)73933-7
Migliorini C, Qian Y, Chen H, Brown EB, Jain RK, Munn LL
Red blood cells augment leukocyte rolling in a virtual blood vessel.
Biophys J. 2002;83(4):1834-41 - PMID: 12324405 - PMCID: PMC1302276 - DOI: 10.1016/S0006-3495(02)73948-9
Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Cancer Res. 2002;62(23):6831-6 - PMID: 12460895
Jain RK
Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.
Semin Oncol. 2002;29(6 Suppl 16):3-9 - PMID: 12516032 - DOI: 10.1053/sonc.2002.37265
Friedrich SW, Lin SC, Stoll BR, Baxter LT, Munn LL, Jain RK
Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.
Neoplasia. 2002;4(5):449-63 - PMID: 12192604 - PMCID: PMC1661679 - DOI: 10.1038/sj.neo.7900260
Chung HW, Chung HJ
Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683-3688, 2000.
Cancer Res. 2001;61(22):8347-50 - PMID: 11719469
Jain RK, Munn LL, Fukumura D
Transparent Window Models and Intravital Microscopy: Imaging Gene Expression
Physiological Function and Drug Delivery in Tumors, In: Tumor Models in Cancer Research, B. Teicher, Ed., Humana Press, Inc., Totowa, NJ. 2001;Chapter 34:647-671
Jain RK
In Memoriam: Pietro M. Gullino (1919-2001)
Cancer Research. 2001;61:8930-8931
Baish JW, Jain RK
Correspondence Regarding Fractals and Cancer.
Cancer Research. 2001;61:8347-8351
Jain RK, Carmeliet PF
Vessels of death or life.
Sci Am. 2001;285(6):38-45 - PMID: 11759584
Jain RK, Forbes NS
Can engineered bacteria help control cancer?
Proc Natl Acad Sci U S A. 2001;98(26):14748-50 - PMID: 11752416 - PMCID: PMC64926 - DOI: 10.1073/pnas.261606598
Jain RK
Transport of molecules, particles, and cells in solid tumors.
Annu Rev Biomed Eng. 2001;1:241-63 - PMID: 11701489 - DOI: 10.1146/annurev.bioeng.1.1.241
Jain RK
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.
Nat Med. 2001;7(9):987-9 - PMID: 11533692 - DOI: 10.1038/nm0901-987
Jain RK
Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.
J Control Release. 2001;74(1-3):7-25 - PMID: 11489479
Jain RK
Clearing the smoke on nicotine and angiogenesis.
Nat Med. 2001;7(7):775-7 - PMID: 11433337 - DOI: 10.1038/89889
Jain RK
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2001;46(1-3):149-68 - PMID: 11259838
Ding L, Sunamura M, Kodama T, Yamauchi J, Duda DG, Shimamura H, Shibuya K, Takeda K, Matsuno S
In vivo evaluation of the early events associated with liver metastasis of circulating cancer cells
Br J Cancer. 2001;85:431-8 - PMID: 11487277 - PMCID: PMC2364062 - DOI: 10.1054/bjoc.2001.1911
Yuan J, Melder RJ, Jain RK, Munn LL
Lateral view flow system for studies of cell adhesion and deformation under flow conditions.
Biotechniques. 2001;30(2):388-94 - PMID: 11233608 - PMCID: PMC2752719 - DOI: 10.2144/01302rr02
Dull RO, Yuan J, Chang YS, Tarbell J, Jain RK, Munn LL
Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation.
Microvasc Res. 2001;61(2):203-10 - PMID: 11254400 - DOI: 10.1006/mvre.2000.2298
Melder RJ, Kristensen CA, Munn LL, Jain RK
Modulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery.
Biorheology. 2001;38(2-3):151-9 - PMID: 11381172
Patan S, Munn LL, Tanda S, Roberge S, Jain RK, Jones RC
Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy.
Circ Res. 2001;89(8):723-31 - PMID: 11597996
Patan S, Tanda S, Roberge S, Jones RC, Jain RK, Munn LL
Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation.
Circ Res. 2001;89(8):732-9 - PMID: 11597997 - PMCID: PMC2752899
Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Cancer Res. 2001;61(1):39-44 - PMID: 11196192
Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Proc Natl Acad Sci U S A. 2001;98(8):4628-33 - PMID: 11274375 - PMCID: PMC31885 - DOI: 10.1073/pnas.081626898
Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer Res. 2001;61(6):2404-8 - PMID: 11289105
Davies Cde L, Melder RJ, Munn LL, Mouta-Carreira C, Jain RK, Boucher Y
Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.
Microvasc Res. 2001;62(1):26-42 - PMID: 11421658 - DOI: 10.1006/mvre.2001.2311
Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Nat Med. 2001;7(7):864-8 - PMID: 11433354 - DOI: 10.1038/89997
Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
Cancer Res. 2001;61(16):6020-4 - PMID: 11507045
Tsuzuki Y, Mouta Carreira C, Bockhorn M, Xu L, Jain RK, Fukumura D
Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Lab Invest. 2001;81(10):1439-51 - PMID: 11598156
Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK
LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer Res. 2001;61(22):8079-84 - PMID: 11719431
Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA
A potential murine model for flap-related investigations.
Plast Reconstr Surg. 2001;107(6):1504-8 - PMID: 11335827 - DOI: 10.1097/00006534-200105000-00032
Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.
Proc Natl Acad Sci U S A. 2001;98(5):2604-9 - PMID: 11226286 - PMCID: PMC30185 - DOI: 10.1073/pnas.041359198
Jain RK
Delivery of Biologic Molecules and Cells to Tumors
In: Biologic Therapy of Cancer: Principles and Practice, S. Rosenberg, Ed., Lippincott, Williams and Watkins, Philadelphia. 2000;:865-874
Carmeliet P, Jain RK
Angiogenesis in cancer and other diseases.
Nature. 2000;407(6801):249-57 - PMID: 11001068 - DOI: 10.1038/35025220
Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK
Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.
Cancer Res. 2000;60(16):4324-7 - PMID: 10969769
Baish JW, Jain RK
Fractals and cancer.
Cancer Res. 2000;60(14):3683-8 - PMID: 10919633
Helmlinger G, Endo M, Ferrara N, Hlatky L, Jain RK
Formation of endothelial cell networks.
Nature. 2000;405(6783):139-41 - PMID: 10821260 - DOI: 10.1038/35012132
Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK
Role of extracellular matrix assembly in interstitial transport in solid tumors.
Cancer Res. 2000;60(9):2497-503 - PMID: 10811131
Dellian M, Yuan F, Trubetskoy VS, Torchilin VP, Jain RK
Vascular permeability in a human tumour xenograft: molecular charge dependence.
Br J Cancer. 2000;82(9):1513-8 - PMID: 10789717 - PMCID: PMC2363402 - DOI: 10.1054/bjoc.1999.1171
Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, Jain RK, McDonald DM
Openings between defective endothelial cells explain tumor vessel leakiness.
Am J Pathol. 2000;156(4):1363-80 - PMID: 10751361 - PMCID: PMC1876882 - DOI: 10.1016/S0002-9440(10)65006-7
Fidler IJ, Bielenberg DR, Slaton J, Xu L, Dinney CPN, Dong Z
Interferon-mediated antiangiogenic therapy
Journal of National Cancer Institute. 2000;1092:4-12
Fidler IJ, Singh RK, Yoneda J, Kumar R, Xu L, Dong Z, Bielenberg DR, McCarty M, Ellis LM
Critical determinants of neoplastic angiogenesis
The Cancer Journal. 2000;6 (supl 3):S225-­S236 - PMID: 10874492
Xu L, Fidler IJ
Interleukin 8: an autocrine growth factor for human ovarian cancer.
Oncol Res. 2000;12(2):97-106 - PMID: 11132928
Xu L, Yoneda J, Herrera C, Wood J, Killion JJ, Fidler IJ
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
Int J Oncol. 2000;16(3):445-54 - PMID: 10675474
Xu L, Fidler IJ
Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells.
Cancer Res. 2000;60(16):4610-6 - PMID: 10969814
Ramanujan S, Koenig GC, Padera TP, Stoll BR, Jain RK
Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
Cancer Res. 2000;60(5):1442-8 - PMID: 10728711
Sunamura M, Sun L, Lozonschi L, Duda DG, Kodama T, Matsumoto G, Shimamura H, Takeda K, Kobari M, Hamada H, Matsuno S
The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice.
Pancreas. 2000;20(3):227-33 - PMID: 10766447
Duda DG, Sunamura M, Lozonschi L, Kodama T, Egawa S, Matsumoto G, Shimamura H, Shibuya K, Takeda K, Matsuno S
Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12.
Cancer Res. 2000;60(4):1111-6 - PMID: 10706132
Motoi F, Sunamura M, Ding L, Duda DG, Yoshida Y, Zhang W, Matsuno S, Hamada H
Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.
Hum Gene Ther. 2000;11(2):223-35 - PMID: 10680837 - DOI: 10.1089/10430340050015978
Jain RK, Munn LL
Leaky vessels? Call Ang1!
Nat Med. 2000;6(2):131-2 - PMID: 10655092 - DOI: 10.1038/72212
Chang YS, Munn LL, Hillsley MV, Dull RO, Yuan J, Lakshminarayanan S, Gardner TW, Jain RK, Tarbell JM
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Microvasc Res. 2000;59(2):265-77 - PMID: 10684732 - DOI: 10.1006/mvre.1999.2225
Melder RJ, Yuan J, Munn LL, Jain RK
Erythrocytes enhance lymphocyte rolling and arrest in vivo.
Microvasc Res. 2000;59(2):316-22 - PMID: 10684738 - DOI: 10.1006/mvre.1999.2223
Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL
Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.
Proc Natl Acad Sci U S A. 2000;97(26):14608-13 - PMID: 11121063 - PMCID: PMC18966 - DOI: 10.1073/pnas.97.26.14608
McDonald DM, Munn L, Jain RK
Vasculogenic mimicry: how convincing, how novel, and how significant?
Am J Pathol. 2000;156(2):383-8 - PMID: 10666365 - PMCID: PMC1850027 - DOI: 10.1016/S0002-9440(10)64740-2
Hartford AC, Gohongi T, Fukumura D, Jain RK
Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.
Cancer Res. 2000;60(8):2128-31 - PMID: 10786673
Stohrer M, Boucher Y, Stangassinger M, Jain RK
Oncotic pressure in solid tumors is elevated.
Cancer Res. 2000;60(15):4251-5 - PMID: 10945638
Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK
Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Cancer Res. 2000;60(16):4556-60 - PMID: 10969807
Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer Res. 2000;60(19):5565-70 - PMID: 11034104
Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--&amp;gt; hypoxia response element--&amp;gt; VEGF cascade differentially regulates vascular response and growth rate in tumors.
Cancer Res. 2000;60(22):6248-52 - PMID: 11103778
Kaur A, Hale CL, Ramanujan S, Jain RK, Johnson RP
Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection.
J Virol. 2000;74(18):8413-24 - PMID: 10954541 - PMCID: PMC116352 - DOI: 10.1128/jvi.74.18.8413-8424.2000
Somasundaran P, Simpson S, Jain RK, Ivanov I, Raghuraman V
Investigation of Thin Aqueous Films on Silica Using a Modified Interferometric Technique.
J Colloid Interface Sci. 2000;225(1):243-246 - PMID: 10767167 - DOI: 10.1006/jcis.2000.6735
Somasundaran P, Simpson S, Ivanov I, Jain RK, Sarkar D
Thinning and Rupture of Aqueous Surfactant Films on Silica
Langmuir. 1999;15:7658-7661
Kristensen CA, Hamberg LM, Hunter GJ, Roberge S, Kierstead D, Wolf GL, Jain RK
Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy.
Neoplasia. 1999;1(6):518-25 - PMID: 10935499 - PMCID: PMC1508121
Heijn M, Roberge S, Jain RK
Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor.
Cancer Res. 1999;59(17):4458-63 - PMID: 10485498
Endo M, Jain RK, Witwer B, Brown D
Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas.
Microvasc Res. 1999;58(2):89-98 - PMID: 10458924 - DOI: 10.1006/mvre.1999.2158
Jain RK
Understanding barriers to drug delivery: high resolution in vivo imaging is key.
Clin Cancer Res. 1999;5(7):1605-6 - PMID: 10430057
Moulton KS, Melder RJ, Dharnidharka VR, Hardin-Young J, Jain RK, Briscoe DM
Angiogenesis in the huPBL-SCID model of human transplant rejection.
Transplantation. 1999;67(12):1626-31 - PMID: 10401773
Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK
Return of lymphatic function after flap transfer for acute lymphedema.
Ann Surg. 1999;229(3):421-7 - PMID: 10077056 - PMCID: PMC1191709
Kristensen CA, Askenasy N, Jain RK, Koretsky AP
Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies.
Br J Cancer. 1999;79(2):278-85 - PMID: 9888469 - PMCID: PMC2362210 - DOI: 10.1038/sj.bjc.6690045
Xu L, Xie K, Mukaida N, Matsushima K, Fidler IJ
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
Cancer Res. 1999;59(22):5822-9 - PMID: 10582705
Lichtenbeld HC, Ferarra N, Jain RK, Munn LL
Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.
Microvasc Res. 1999;57(3):357-62 - PMID: 10329263 - DOI: 10.1006/mvre.1998.2140
Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA
Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.
Microcirculation. 1999;5(2-3):153-71 - PMID: 9789256
Suzuki M, Mori M, Fukumura D, Suzuki H, Miura S, Ishii H
Omeprazole attenuates neutrophil-endothelial cell adhesive interaction induced by extracts of Helicobacter pylori.
J Gastroenterol Hepatol. 1999;14(1):27-31 - PMID: 10029274
Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK
Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.
Proc Natl Acad Sci U S A. 1999;96(6):3137-42 - PMID: 10077650 - PMCID: PMC15908
Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK
Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.
Cancer Res. 1999;59(15):3776-82 - PMID: 10446995
Monsky WL, Fukumura D, Gohongi T, Ancukiewcz M, Weich HA, Torchilin VP, Yuan F, Jain RK
Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Cancer Res. 1999;59(16):4129-35 - PMID: 10463618
Toyama T, Iwase H, Watson P, Muzik H, Saettler E, Magliocco A, DiFrancesco L, Forsyth P, Garkavtsev I, Kobayashi S, Riabowol K
Suppression of ING1 expression in sporadic breast cancer.
Oncogene. 1999;18(37):5187-93 - PMID: 10498868 - DOI: 10.1038/sj.onc.1202905
Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK
Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Nat Med. 1999;5(10):1203-8 - PMID: 10502827 - DOI: 10.1038/13524
Garkavtsev I
Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation
Nat Genet. 1999;23(3):373 - PMID: 10545957 - DOI: 10.1038/15564
Swartz MA, Kristensen CA, Melder RJ, Roberge S, Calautti E, Fukumura D, Jain RK
Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.
Br J Cancer. 1999;81(5):756-9 - PMID: 10555742 - PMCID: PMC2374305 - DOI: 10.1038/sj.bjc.6690760
Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK
Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
J Biomech. 1999;32(12):1297-307 - PMID: 10569708
Pluen A, Netti PA, Jain RK, Berk DA
Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations.
Biophys J. 1999;77(1):542-52 - PMID: 10388779 - PMCID: PMC1300351 - DOI: 10.1016/S0006-3495(99)76911-0
Berlin K, Jain RK, Richert C
Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins.
Biotechnol Bioeng. 1998;61(2):107-18 - PMID: 10099504
Jain RK
Delivery of Monoclonal Antibodies to the Tumor Cell
In: Monoclonal Antibody-Based Therapy of Cancer, M.L. Grossbard, Ed., Marcel Dekker, Inc., New York. 1998;:23-52
Jain RK, Munn LL, Fukumura D, Melder RJ
In Vitro and In Vivo Quantification of Adhesion Between Leukocytes and Vascular Endothelium.
In: Methods in Molecular Medicine - Methods in Tissue Engineering, J.R. Morgan and M.L. Yarmush, Eds., Humana Press, Totowa. 1998;:553-575
Jain RK
Microcirculation and Transport Phenomena in Tumours
In: Connective Tissue Biology: Integration and Reductionism. Eds. R.K. Reed and K. Rubin, Portland Press Ltd, London. 1998;71:269-293
Sckell A, Safabakhsh N, Dellian M, Jain RK
Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice.
Cancer Res. 1998;58(24):5866-9 - PMID: 9865747
Jain RK
Delivery of molecular and cellular medicine to solid tumors.
J Control Release. 1998;53(1-3):49-67 - PMID: 9741913
Baish JW, Jain RK
Cancer, angiogenesis and fractals.
Nat Med. 1998;4(9):984 - PMID: 9734370 - DOI: 10.1038/1952
Jain RK, Safabakhsh N, Sckell A, Chen Y, Jiang P, Benjamin L, Yuan F, Keshet E
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor.
Proc Natl Acad Sci U S A. 1998;95(18):10820-5 - PMID: 9724788 - PMCID: PMC27979
Jain RK
The next frontier of molecular medicine: delivery of therapeutics.
Nat Med. 1998;4(6):655-7 - PMID: 9623964
Jain RK
Integrative pathophysiology of solid tumors: role in detection and treatment.
Cancer J Sci Am. 1998;4 Suppl 1:S48-57 - PMID: 9619271
Rosenzweig M, DeMaria MA, Harper DM, Friedrich S, Jain RK, Johnson RP
Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques.
Proc Natl Acad Sci U S A. 1998;95(11):6388-93 - PMID: 9600975 - PMCID: PMC27734
Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R
Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.
Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01
Hunter GJ, Hamberg LM, Choi N, Jain RK, McCloud T, Fischman AJ
Dynamic T1-weighted magnetic resonance imaging and positron emission tomography in patients with lung cancer: correlating vascular physiology with glucose metabolism.
Clin Cancer Res. 1998;4(4):949-55 - PMID: 9563889
Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
Proc Natl Acad Sci U S A. 1998;95(8):4607-12 - PMID: 9539785 - PMCID: PMC22537
Zhu H, Jain RK, Baxter LT
Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
J Nucl Med. 1998;39(1):65-76 - PMID: 9443740
Xu L, Xie K, Fidler IJ
Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase.
Hum Gene Ther. 1998;9(18):2699-708 - PMID: 9874268 - DOI: 10.1089/hum.1998.9.18-2699
Juang SH, Xie K, Xu L, Shi Q, Wang Y, Yoneda J, Fidler IJ
Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene.
Hum Gene Ther. 1998;9(6):845-54 - PMID: 9581907 - DOI: 10.1089/hum.1998.9.6-845
Huang P, Olive PL, Durand RE
Use of the comet assay for assessment of drug resistance and its modulation in vivo.
Br J Cancer. 1998;77(3):412-6 - PMID: 9472636 - PMCID: PMC2151301
Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV
The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control.
Nature. 1998;391(6664):295-8 - PMID: 9440695 - DOI: 10.1038/34675
Garkavtsev I, Hull C, Riabowol K
Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence.
Exp Gerontol. 1998;33(1-2):81-94 - PMID: 9467719
Fukumura D, Jain RK
Role of nitric oxide in angiogenesis and microcirculation in tumors.
Cancer Metastasis Rev. 1998;17(1):77-89 - PMID: 9544424
Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK
Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.
J Invest Dermatol. 1998;111(1):1-6 - PMID: 9665379 - DOI: 10.1046/j.1523-1747.1998.00262.x
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E, Keshet E
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Nature. 1998;394(6692):485-90 - PMID: 9697772 - DOI: 10.1038/28867
Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B
Tumor induction of VEGF promoter activity in stromal cells.
Cell. 1998;94(6):715-25 - PMID: 9753319
Boucher Y, Brekken C, Netti PA, Baxter LT, Jain RK
Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.
Br J Cancer. 1998;78(11):1442-8 - PMID: 9836476 - PMCID: PMC2063228
Jain RK
Tumor Microcirculation: Role in Drug and Nutrient Delivery
In: Advances in Blood Substitutes, Eds, R.M. Winslow, K. D. Vandegriff, and M. Intaglietta, Birkhuser, Boston. 1997;:46-70
Jain RK
Delivery of Molecular Medicine to Solid Tumors
In: Microcirculation Annual 1997, M. Tsuchiya, M. Asano and N. Sato, Eds, Nihon-Igakukan, Tokyo. 1997;13:1-5
Jain RK
Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection and Treatment
In: Tumor Angiogenesis, R. Bicknell, C. Lewis and N. Ferrara, Eds, Oxford University Press, Oxford. 1997;:45-59
Jain RK
Tumor Microcirculation: Role in Delivery of Molecular and Cellular Medicine
In: The Biology of Tumors, Proceedings of the Ninth Annual Pezcoller Symposium on the Biology of Tumors, Rovereto, Italy. 1997;:319-345
Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK
Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors
AIChE Journal. 1997;43:818-834
Kristensen CA, Roberge S, Jain RK
Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts.
Clin Cancer Res. 1997;3(3):319-24 - PMID: 10026014
Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, Jain RK
Fractal characteristics of tumor vascular architecture during tumor growth and regression.
Microcirculation. 1997;4(4):395-402 - PMID: 9431507
Jain RK, Schlenger K, Höckel M, Yuan F
Quantitative angiogenesis assays: progress and problems.
Nat Med. 1997;3(11):1203-8 - PMID: 9359693
Griffon-Etienne G, Boucher Y, Jain RK, Suit HD
Effects of needle insertion in tumors on interstitial fluid pressure.
Microvasc Res. 1997;54(2):174-7 - PMID: 9327388 - DOI: 10.1006/mvre.1997.2037
Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, Dewhirst MW, Milross CG, Milas L, Song CW, Thomas CD, Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, Suit HD
Interlaboratory variation in oxygen tension measurement by Eppendorf &amp;quot;Histograph&amp;quot; and comparison with hypoxic marker.
J Surg Oncol. 1997;66(1):30-8 - PMID: 9290690
Helmlinger G, Netti PA, Lichtenbeld HC, Melder RJ, Jain RK
Solid stress inhibits the growth of multicellular tumor spheroids.
Nat Biotechnol. 1997;15(8):778-83 - PMID: 9255794 - DOI: 10.1038/nbt0897-778
Leunig M, Yuan F, Gerweck LE, Jain RK
Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice.
Int J Microcirc Clin Exp. 1997;17(1):1-9 - PMID: 9176719
Baish JW, Netti PA, Jain RK
Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Microvasc Res. 1997;53(2):128-41 - PMID: 9143544 - DOI: 10.1006/mvre.1996.2005
Less JR, Posner MC, Skalak TC, Wolmark N, Jain RK
Geometric resistance and microvascular network architecture of human colorectal carcinoma.
Microcirculation. 1997;4(1):25-33 - PMID: 9110281
Jain RK
The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.
Microcirculation. 1997;4(1):1-23 - PMID: 9110280
Briscoe DM, Ganz P, Alexander SI, Melder RJ, Jain RK, Cotran RS, Lichtman AH
The problem of chronic rejection: influence of leukocyte-endothelial interactions.
Kidney Int Suppl. 1997;58:S22-7 - PMID: 9067938
Berk DA, Yuan F, Leunig M, Jain RK
Direct in vivo measurement of targeted binding in a human tumor xenograft.
Proc Natl Acad Sci U S A. 1997;94(5):1785-90 - PMID: 9050856 - PMCID: PMC19994
Helmlinger G, Yuan F, Dellian M, Jain RK
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Nat Med. 1997;3(2):177-82 - PMID: 9018236
Juang SH, Xie K, Xu L, Wang Y, Yoneda J, Fidler IJ
Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma.
Cancer Biother Radiopharm. 1997;12(3):167-75 - PMID: 10851463 - DOI: 10.1089/cbr.1997.12.167
Xie K, Bielenberg D, Huang S, Xu L, Salas T, Juang SH, Dong Z, Fidler IJ
Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.
Clin Cancer Res. 1997;3(12 Pt 1):2283-94 - PMID: 9815626
Xie K, Wang Y, Huang S, Xu L, Bielenberg D, Salas T, McConkey DJ, Jiang W, Fidler IJ
Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2.
Oncogene. 1997;15(7):771-9 - PMID: 9266963 - DOI: 10.1038/sj.onc.1201239
Melder RJ, Koenig GC, Munn LL, Jain RK
Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.
Nat Immun. 1997;15(2-3):154-63 - PMID: 9162265
Shioda T, Munn LL, Fenner MH, Jain RK, Isselbacher KJ
Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.
Am J Pathol. 1997;150(6):2099-112 - PMID: 9176401 - PMCID: PMC1858325
Suzuki M, Mori M, Miura S, Suematsu M, Fukumura D, Kimura H, Ishii H
Omeprazole attenuates oxygen-derived free radical production from human neutrophils.
Free Radic Biol Med. 1997;21(5):727-31 - PMID: 8891677
Boucher Y, Salehi H, Witwer B, Harsh GR, Jain RK
Interstitial fluid pressure in intracranial tumours in patients and in rodents.
Br J Cancer. 1997;75(6):829-36 - PMID: 9062403 - PMCID: PMC2063404
Garkavtsev I, Demetrick D, Riabowol K
Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1).
Cytogenet Cell Genet. 1997;76(3-4):176-8 - PMID: 9186514 - DOI: 10.1159/000134539
Fukumura D, Yuan F, Endo M, Jain RK
Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.
Am J Pathol. 1997;150(2):713-25 - PMID: 9033284 - PMCID: PMC1858293
Tanaka S, Miura S, Kimura H, Ohkubo N, Tsuzuki Y, Fukumura D, Serizawa H, Kurose I, Mori M, Ishii H
Amelioration of chronic inflammation by ingestion of elemental diet in a rat model of granulomatous enteritis.
Dig Dis Sci. 1997;42(2):408-19 - PMID: 9052527
Helbing CC, Veillette C, Riabowol K, Johnston RN, Garkavtsev I
A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis.
Cancer Res. 1997;57(7):1255-8 - PMID: 9102209
Garkavtsev I, Riabowol K
Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor.
Mol Cell Biol. 1997;17(4):2014-9 - PMID: 9121449 - PMCID: PMC232048
Higuchi H, Kurose I, Fukumura D, Yan HJ, Saito H, Miura S, Hokari R, Watanabe N, Zeki S, Yoshida M, Kitajima M, Granger DN, Ishii H
Active oxidants mediate IFN-alpha-induced microvascular alterations in rat mesentery.
J Immunol. 1997;158(10):4893-900 - PMID: 9144506
Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.
Science. 1997;276(5317):1423-5 - PMID: 9162011
Garkavtsev I, Mizukami T
Integrated map of the Schizosaccharomyces pombe genome.
Chromosoma. 1997;106(4):254-65 - PMID: 9254727
Fukumura D, Yuan F, Monsky WL, Chen Y, Jain RK
Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
Am J Pathol. 1997;151(3):679-88 - PMID: 9284816 - PMCID: PMC1857859
Horie Y, Kato S, Ohki E, Hamamatsu H, Fukumura D, Kurose I, Suzuki H, Suematsu M, Miura S, Ishii H
Effect of lipopolysaccharides on erythrocyte flow velocity in rat liver.
J Gastroenterol. 1997;32(6):783-90 - PMID: 9430017
Garkavtsev I, Boland D, Mai J, Wilson H, Veillette C, Riabowol K
Specific monoclonal antibody raised against the p33ING1 tumor suppressor.
Hybridoma. 1997;16(6):537-40 - PMID: 9455706 - DOI: 10.1089/hyb.1997.16.537
Jain RK
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 1997;26(2-3):71-90 - PMID: 10837535 - DOI: 10.1016/s0169-409x(97)00027-6
Zhu H, Baxter LT, Jain RK
Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.
J Nucl Med. 1997;38(5):731-41 - PMID: 9170438
Neelamegham S, Munn LL, Zygourakis K
A model for the kinetics of homotypic cellular aggregation under static conditions.
Biophys J. 1997;72(1):51-64 - PMID: 8994592 - PMCID: PMC1184296 - DOI: 10.1016/S0006-3495(97)78646-6
Jain RK
Solid Tumor Barriers to Anticancer Drugs.
Cope. 1996;12:22-23
Saltzman WM, Jain RK
Drug Delivery: Barriers to Drug Transport and the Design of Novel Therapeutic Agents.
Molecular Medicine Today. 1996;1:4
Kristjansen PE, Brown TJ, Shipley LA, Jain RK
Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.
Clin Cancer Res. 1996;2(2):359-67 - PMID: 9816179
Lichtenbeld HC, Yuan F, Michel CC, Jain RK
Perfusion of single tumor microvessels: application to vascular permeability measurement.
Microcirculation. 1996;3(4):349-57 - PMID: 9086446
Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK
Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Microvasc Res. 1996;51(3):327-46 - PMID: 8992232 - DOI: 10.1006/mvre.1996.0031
Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Proc Natl Acad Sci U S A. 1996;93(25):14765-70 - PMID: 8962129 - PMCID: PMC26210
Johnson ME, Berk DA, Blankschtein D, Golan DE, Jain RK, Langer RS
Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Biophys J. 1996;71(5):2656-68 - PMID: 8913603 - PMCID: PMC1233752 - DOI: 10.1016/S0006-3495(96)79457-2
Dellian M, Helmlinger G, Yuan F, Jain RK
Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.
Br J Cancer. 1996;74(8):1206-15 - PMID: 8883406 - PMCID: PMC2075944
Jain RK
1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Ann Biomed Eng. 1996;24(4):457-73 - PMID: 8841721
Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK
Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice.
Acta Orthop Scand. 1996;67(4):383-8 - PMID: 8792744
Zhu H, Melder RJ, Baxter LT, Jain RK
Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Cancer Res. 1996;56(16):3771-81 - PMID: 8706023
Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK
Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.
Am J Pathol. 1996;149(1):59-71 - PMID: 8686763 - PMCID: PMC1865247
Nozue M, Lee I, Manning JM, Manning LR, Jain RK
Oxygenation in tumors by modified hemoglobins.
J Surg Oncol. 1996;62(2):109-14 - PMID: 8649036 - DOI: 10.1002/(SICI)1096-9098(199606)62:2&lt;109::AID-JSO6&gt;3.0.CO;2-C
Jain RK
Delivery of molecular medicine to solid tumors.
Science. 1996;271(5252):1079-80 - PMID: 8599082
Leunig M, Yuan F, Gerweck LE, Berk DA, Jain RK
Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach.
Res Exp Med (Berl). 1996;195(5):275-88 - PMID: 8578003
Nozue M, Lee I, Hartford A, Tanda S, Suit H, Jain R
pO(2) measurement in murine tumors by Eppendorf 'Histograph'.
Int J Oncol. 1996;9(5):955-62 - PMID: 21541601
Skalak R, Zargaryan S, Jain RK, Netti PA, Hoger A
Compatibility and the genesis of residual stress by volumetric growth.
J Math Biol. 1996;34(8):889-914 - PMID: 8858855
Johnson EM, Berk DA, Jain RK, Deen WM
Hindered diffusion in agarose gels: test of effective medium model.
Biophys J. 1996;70(2):1017-23 - PMID: 8789119 - PMCID: PMC1225002 - DOI: 10.1016/S0006-3495(96)79645-5
Berk DA, Swartz MA, Leu AJ, Jain RK
Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching.
Am J Physiol. 1996;270(1 Pt 2):H330-7 - PMID: 8769769 - DOI: 10.1152/ajpheart.1996.270.1.H330
Swartz MA, Berk DA, Jain RK
Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory.
Am J Physiol. 1996;270(1 Pt 2):H324-9 - PMID: 8769768 - DOI: 10.1152/ajpheart.1996.270.1.H324
Baxter LT, Jain RK
Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.
Br J Cancer. 1996;73(4):447-56 - PMID: 8595158 - PMCID: PMC2074453
Huang P, Taghian A, Allam A, Freeman J, Duffy M, Suit H
The effect of whole-body irradiation of nude mice on the tumor transplantability and control probability of a human soft tissue sarcoma xenograft.
Radiat Res. 1996;145(3):337-42 - PMID: 8927702
Huang P, Taghian A, Hsu DW, Perez LA, Allam A, Duffy M, DaCosta A, Suit HD
Spontaneous metastasis, proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenografts.
Radiother Oncol. 1996;41(1):73-81 - PMID: 8961371
Huang P, Suit HD
Spontaneous osteosarcoma in a severe combined immunodeficient (SCID/Sed) mouse.
Contemp Top Lab Anim Sci. 1996;35(6):75-7 - PMID: 16450991
Patan S, Munn LL, Jain RK
Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.
Microvasc Res. 1996;51(2):260-72 - PMID: 8778579 - DOI: 10.1006/mvre.1996.0025
Melder RJ, Koenig GC, Witwer BP, Safabakhsh N, Munn LL, Jain RK
During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.
Nat Med. 1996;2(9):992-7 - PMID: 8782456
Munn LL, Melder RJ, Jain RK
Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.
Biophys J. 1996;71(1):466-78 - PMID: 8804629 - PMCID: PMC1233497 - DOI: 10.1016/S0006-3495(96)79248-2
Yoshida M, Fukumura D, Wakabayashi G, Otani Y, Oshima A, Shimazu M, Kubota T, Kumai K, Kurose I, Miura S
Gastric microcirculatory disturbance and behaviour of leucocytes after thermal injury: intravital observation of arteriovenous shunting channels in the gastric submucosal layer.
J Gastroenterol Hepatol. 1996;10(4):365-70 - PMID: 8527699
Miura S, Fukumura D, Shiozaki H, Suzuki M, Kurose I, Suematsu M, Tsuchiya M, Ishii H
Bile acid-induced depolarization of mitochondrial membrane potential preceding cell injury in cultured gastric mucosal cells.
J Gastroenterol Hepatol. 1996;10(6):621-6 - PMID: 8580403
Suzuki H, Miura S, Imaeda H, Suzuki M, Han JY, Mori M, Fukumura D, Tsuchiya M, Ishii H
Enhanced levels of chemiluminescence and platelet activating factor in urease-positive gastric ulcers.
Free Radic Biol Med. 1996;20(3):449-54 - PMID: 8720917
Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK
Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer Res. 1996;56(5):964-68 - PMID: 8640786
Fukumura D, Kurose I, Miura S, Serizawa H, Sekizuka E, Nagata H, Tsuchiya M, Ishii H
Role of endothelin-1 in repeated electrical stimulation-induced microcirculatory disturbance and mucosal damage in rat stomach.
J Gastroenterol Hepatol. 1996;11(3):279-85 - PMID: 8742927
Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJ
Leukocyte-endothelial adhesion and angiogenesis in tumors.
Cancer Metastasis Rev. 1996;15(2):195-204 - PMID: 8842491
Fukumura D, Yonei Y, Kurose I, Saito H, Ohishi T, Higuchi H, Miura S, Kato S, Kimura H, Ebinuma H, Ishi H
Role in nitric oxide in Kupffer cell-mediated hepatoma cell cytotoxicity in vitro and ex vivo.
Hepatology. 1996;24(1):141-9 - PMID: 8707254 - DOI: 10.1053/jhep.1996.v24.pm0008707254
Saito H, Kurose I, Ebinuma H, Fukumura D, Higuchi H, Atsukawa K, Tada S, Kimura H, Yonei Y, Masuda T, Miura S, Ishii H
Kupffer cell-mediated cytotoxicity against hepatoma cells occurs through production of nitric oxide and adhesion via ICAM-1/CD18.
Int Immunol. 1996;8(7):1165-72 - PMID: 8757962
Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK
Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Microvasc Res. 1996;52(1):27-46 - PMID: 8812751 - DOI: 10.1006/mvre.1996.0041
Kristensen CA, Nozue M, Boucher Y, Jain RK
Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
Br J Cancer. 1996;74(4):533-6 - PMID: 8761366 - PMCID: PMC2074665
Miura S, Fukumura D, Kurose I, Higuchi H, Kimura H, Tsuzuki Y, Shigematsu T, Han JY, Tsuchiya M, Ishii H
Roles of ET-1 in endotoxin-induced microcirculatory disturbance in rat small intestine.
Am J Physiol. 1996;271(3 Pt 1):G461-9 - PMID: 8843771 - DOI: 10.1152/ajpgi.1996.271.3.G461
Boucher Y, Leunig M, Jain RK
Tumor angiogenesis and interstitial hypertension.
Cancer Res. 1996;56(18):4264-6 - PMID: 8797602
Kurose I, Higuchi H, Yonei Y, Ebinuma H, Watanabe N, Hokari R, Fukumura D, Miura S, Takaishi M, Saito H, Nakatsumi RC, Ishii H
Rat Kupffer cell-derived nitric oxide suppresses proliferation and induces apoptosis of syngeneic hepatoma cells.
Gastroenterology. 1996;111(4):1058-70 - PMID: 8831602
Kurose I, Miura S, Higuchi H, Watanabe N, Kamegaya Y, Takaishi M, Tomita K, Fukumura D, Kato S, Ishii H
Increased nitric oxide synthase activity as a cause of mitochondrial dysfunction in rat hepatocytes: roles for tumor necrosis factor alpha.
Hepatology. 1996;24(5):1185-92 - PMID: 8903396 - DOI: 10.1002/hep.510240534
Garkavtsev I, Kazarov A, Gudkov A, Riabowol K
Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation.
Nat Genet. 1996;14(4):415-20 - PMID: 8944021 - DOI: 10.1038/ng1296-415
Fukumura D, Miura S, Kurose I, Higuchi H, Suzuki H, Ebinuma H, Han JY, Watanabe N, Wakabayashi G, Kitajima M, Ishii H
IL-1 is an important mediator for microcirculatory changes in endotoxin-induced intestinal mucosal damage.
Dig Dis Sci. 1996;41(12):2482-92 - PMID: 9011462
Jain RK, Janda KD, Saltzman WM
Drug discovery and delivery.
Mol Med Today. 1995;1(1):4 - PMID: 9415129
Melder RJ, Salehi HA, Jain RK
Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.
Microvasc Res. 1995;50(1):35-44 - PMID: 7476578 - DOI: 10.1006/mvre.1995.1036
Yamada S, Mayadas TN, Yuan F, Wagner DD, Hynes RO, Melder RJ, Jain RK
Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin.
Blood. 1995;86(9):3487-92 - PMID: 7579454
Baxter LT, Zhu H, Mackensen DG, Butler WF, Jain RK
Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.
Cancer Res. 1995;55(20):4611-22 - PMID: 7553638
Yamada S, Melder RJ, Leunig M, Ohkubo C, Jain RK
Leukocyte rolling increases with age.
Blood. 1995;86(12):4707-8 - PMID: 8541569
Huang P, Allam A, Taghian A, Ruka W, Freeman J, Duffy M, Suit HD
Quantitative comparison of xenotransplantation of a human soft tissue sarcoma into the subcutaneous tissue of normal, postincision, and postincision plus indomethacin-treated nude mice.
J Surg Oncol. 1995;58(4):257-62 - PMID: 7723370
Huang P, Allam A, Perez LA, Taghian A, Freeman J, Suit HD
The effect of combining recombinant human tumor necrosis factor-alpha with local radiation on tumor control probability of a human glioblastoma multiforme xenograft in nude mice.
Int J Radiat Oncol Biol Phys. 1995;32(1):93-8 - PMID: 7721643 - DOI: 10.1016/0360-3016(94)00492-4
Allam A, Perez LA, Huang P, Taghian A, Azinovic I, Freeman J, Duffy M, Efird J, Suit HD
The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice.
Int J Radiat Oncol Biol Phys. 1995;32(1):105-11 - PMID: 7721606 - DOI: 10.1016/0360-3016(95)00511-V
Huang P, Allam A, Taghian A, Freeman J, Duffy M, Suit HD
Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice.
J Neurosurg. 1995;83(2):308-15 - PMID: 7616277 - DOI: 10.3171/jns.1995.83.2.0308
Melder RJ, Munn LL, Yamada S, Ohkubo C, Jain RK
Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes.
Biophys J. 1995;69(5):2131-8 - PMID: 8580357 - PMCID: PMC1236447 - DOI: 10.1016/S0006-3495(95)80087-1
Munn LL, Koenig GC, Jain RK, Melder RJ
Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.
Biotechniques. 1995;19(4):622-6, 628-31 - PMID: 8777057
Miura S, Fukumura D, Kurose I, Kimura H, Suzuki M, Morishita T, Nagata H, Tsuchiya M, Ishii H
Spatial heterogeneity of mucosal blood flow during ischemia-reperfusion injury of rat stomach investigated by laser Doppler perfusion imaging.
J Gastroenterol. 1995;30(3):279-86 - PMID: 7647892
Atadja P, Wong H, Garkavtsev I, Veillette C, Riabowol K
Increased activity of p53 in senescing fibroblasts.
Proc Natl Acad Sci U S A. 1995;92(18):8348-52 - PMID: 7667293 - PMCID: PMC41154
Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Cancer Res. 1995;55(17):3752-6 - PMID: 7641188
Boucher Y, Lee I, Jain RK
Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.
Microvasc Res. 1995;50(2):175-82 - PMID: 8538498 - DOI: 10.1006/mvre.1995.1051
Miura S, Tsuzuki Y, Fukumura D, Serizawa H, Suematsu M, Kurose I, Imaeda H, Kimura H, Nagata H, Tsuchiya M
Intravital demonstration of sequential migration process of lymphocyte subpopulations in rat Peyer's patches.
Gastroenterology. 1995;109(4):1113-23 - PMID: 7557076
Fukumura D, Kurose I, Miura S, Tsuchiya M, Ishii H
Oxidative stress in gastric mucosal injury: role of platelet-activating factor-activated granulocytes.
J Gastroenterol. 1995;30(5):565-71 - PMID: 8574326
Fukumura D, Salehi HA, Witwer B, Tuma RF, Melder RJ, Jain RK
Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.
Cancer Res. 1995;55(21):4824-9 - PMID: 7585514
Zlotecki RA, Baxter LT, Boucher Y, Jain RK
Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Microvasc Res. 1995;50(3):429-43 - PMID: 8583955 - DOI: 10.1006/mvre.1995.1069
Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK
Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Cancer Res. 1995;55(22):5451-8 - PMID: 7585615
Kurose I, Miura S, Saito H, Tada S, Fukumura D, Higuchi H, Ishii H
Rat Kupffer cell-derived nitric oxide modulates induction of lymphokine-activated killer cell.
Gastroenterology. 1995;109(6):1958-68 - PMID: 7498662
Gazit Y, Berk DA, Leunig M, Baxter LT, Jain RK
Scale-invariant behavior and vascular network formation in normal and tumor tissue.
Phys Rev Lett. 1995;75(12):2428-2431 - PMID: 10059301 - DOI: 10.1103/PhysRevLett.75.2428
Johnson EM, Berk DA, Jain RK, Deen WM
Diffusion and partitioning of proteins in charged agarose gels.
Biophys J. 1995;68(4):1561-8 - PMID: 7787041 - PMCID: PMC1282050 - DOI: 10.1016/S0006-3495(95)80328-0
Jain RK
Tumor Microcirculation: Role in Cancer Diagnosis and Treatment
In: Progress in Microcirculation Research, H. Niimi, et al, Eds., Pergamon Press, Tarrytown. 1994;:29-36
Jain RK
Transport Phenomena in Tumors
Advances in Chemical Engineering. 1994;20:129-200
Leunig M, Goetz AE, Gamarra F, Zetterer G, Messmer K, Jain RK
Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.
Br J Cancer. 1994;69(1):101-3 - PMID: 8286189 - PMCID: PMC1968758
Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK
Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.
J Natl Cancer Inst. 1994;86(4):293-9 - PMID: 8158684
Baxter LT, Zhu H, Mackensen DG, Jain RK
Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Cancer Res. 1994;54(6):1517-28 - PMID: 8137258
Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK
Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.
Proc Natl Acad Sci U S A. 1994;91(6):2081-5 - PMID: 8134352 - PMCID: PMC43313
Jain RK
Barriers to drug delivery in solid tumors.
Sci Am. 1994;271(1):58-65 - PMID: 8066425
Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Cancer Res. 1994;54(13):3352-6 - PMID: 8012948
Hamberg LM, Kristjansen PE, Hunter GJ, Wolf GL, Jain RK
Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.
Cancer Res. 1994;54(23):6032-6 - PMID: 7954440
Leu AJ, Berk DA, Yuan F, Jain RK
Flow velocity in the superficial lymphatic network of the mouse tail.
Am J Physiol. 1994;267(4 Pt 2):H1507-13 - PMID: 7943396 - DOI: 10.1152/ajpheart.1994.267.4.H1507
Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK
A method for labeling cells for positron emission tomography (PET) studies.
J Immunol Methods. 1994;175(1):79-87 - PMID: 7930641
Melder RJ, Jain RK
Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.
J Immunol Methods. 1994;175(1):69-77 - PMID: 7930640
Martin GR, Jain RK
Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.
Cancer Res. 1994;54(21):5670-4 - PMID: 7923215
Kristjansen PE, Roberge S, Lee I, Jain RK
Tissue-isolated human tumor xenografts in athymic nude mice.
Microvasc Res. 1994;48(3):389-402 - PMID: 7731400 - DOI: 10.1006/mvre.1994.1063
Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK
Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.
Lab Invest. 1994;71(2):300-7 - PMID: 7521447
Melder RJ, Jain RK
Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells.
Cell Biophys. 1994;20(2-3):161-76 - PMID: 1285298
Munn LL, Melder RJ, Jain RK
Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.
Biophys J. 1994;67(2):889-95 - PMID: 7948702 - PMCID: PMC1225432 - DOI: 10.1016/S0006-3495(94)80550-8
Kurose I, Miura S, Fukumura D, Suzuki M, Nagata H, Sekizuka E, Morishita T, Tsuchiya M
Attenuating effect of antithrombin III on the fibrinolytic activation and microvascular derangement in rat gastric mucosa.
Thromb Haemost. 1994;71(1):119-23 - PMID: 8165629
Yonei Y, Kurose I, Fukumura D, Saito H, Miura S, Tsukada N, Oda M, Tsuchiya M
Evidence of direct interaction between Kupffer cells and colon cancer cells: an ultrastructural study of the co-culture.
Liver. 1994;14(1):37-44 - PMID: 8177028
Lee I, Boucher Y, Demhartner TJ, Jain RK
Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline.
Br J Cancer. 1994;69(3):492-6 - PMID: 8123479 - PMCID: PMC1968875
Tashiro H, Miura S, Kurose I, Fukumura D, Suzuki H, Suematsu M, Yoshioka M, Tsuchiya M, Kai A, Kudoh Y
Verotoxin induces hemorrhagic lesions in rat small intestine. Temporal alteration of vasoactive substances.
Dig Dis Sci. 1994;39(6):1230-8 - PMID: 8200255
Lee I, Demhartner TJ, Boucher Y, Jain RK, Intaglietta M
Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation.
Microvasc Res. 1994;48(1):1-12 - PMID: 7990716 - DOI: 10.1006/mvre.1994.1034
Yuan F, Salehi HA, Boucher Y, Vasthare US, Tuma RF, Jain RK
Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.
Cancer Res. 1994;54(17):4564-8 - PMID: 8062241
Suzuki M, Miura S, Mori M, Kai A, Suzuki H, Fukumura D, Suematsu M, Tsuchiya M
Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants.
Gut. 1994;35(10):1375-8 - PMID: 7959190 - PMCID: PMC1375008
Teague TK, Munn L, Zygourakis K, McIntyre BW
Analysis of lymphocyte activation and proliferation by video microscopy and digital imaging.
Cytometry. 1993;14(7):772-82 - PMID: 8243206 - DOI: 10.1002/cyto.990140710
Melder RJ, Jain RK
Delivery of Effector Cells to Tumors
In: '93 Recent Advances in Cancer Research, J.G. Park, Ed., Seoul National University, Seoul. 1993;:202-217
Jain RK
Physiological Resistance to the Treatment of Solid Tumors
In: Drug Resistance in Oncology, B. Teicher, Ed., M. Dekker, New York. 1993;Chapter 4:87-105
Jain RK, Baxter LT
Extravasation and Interstitial Transport in Tumors
In: Biological Barriers to Protein Delivery, K.L. Audus and T.J. Raub, Eds., Plenum Press, New York. 1993;Chapter 15:441-465
Eskey CJ, Koretsky AP, Domach MM, Jain RK
Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.
Proc Natl Acad Sci U S A. 1993;90(7):2646-50 - PMID: 8464871 - PMCID: PMC46152
Yuan F, Leunig M, Berk DA, Jain RK
Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.
Microvasc Res. 1993;45(3):269-89 - PMID: 8321142 - DOI: 10.1006/mvre.1993.1024
Berk DA, Yuan F, Leunig M, Jain RK
Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.
Biophys J. 1993;65(6):2428-36 - PMID: 8312481 - PMCID: PMC1225983 - DOI: 10.1016/S0006-3495(93)81326-2
Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK
Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.
Cancer Res. 1993;53(24):5867-71 - PMID: 8261395
Martin GR, Jain RK
Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.
Microvasc Res. 1993;46(2):216-30 - PMID: 8246820 - DOI: 10.1006/mvre.1993.1048
Munn LL, Glacken MW, McIntyre BW, Zygourakis K
Analysis of lymphocyte aggregation using digital image analysis.
J Immunol Methods. 1993;166(1):11-25 - PMID: 8228280
Mizukami T, Garkavtsev I, Beach D, Marr T, Niwa O, Yanagida M
[Genome mapping of Schizosaccharomyces pombe].
Tanpakushitsu Kakusan Koso. 1993;38(3):677-84 - PMID: 8488304
Mizukami T, Chang WI, Garkavtsev I, Kaplan N, Lombardi D, Matsumoto T, Niwa O, Kounosu A, Yanagida M, Marr TG
A 13 kb resolution cosmid map of the 14 Mb fission yeast genome by nonrandom sequence-tagged site mapping.
Cell. 1993;73(1):121-32 - PMID: 8462095
Miura S, Imaeda H, Shiozaki H, Kurose I, Fukumura D, Tashiro H, Serizawa H, Suematsu M, Sekizuka E, Tsuchiya M
Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid.
Am J Physiol. 1993;264(5 Pt 1):G828-34 - PMID: 8498509 - DOI: 10.1152/ajpgi.1993.264.5.G828
Kurose I, Suematsu M, Miura S, Fukumura D, Sekizuka E, Nagata H, Oshio C, Tsuchiya M
Oxyradical generation from leukocytes during endotoxin-induced microcirculatory disturbance in rat mesentery--attenuating effect of cetraxate.
Toxicol Appl Pharmacol. 1993;120(1):37-44 - PMID: 8511781 - DOI: 10.1006/taap.1993.1084
Kurose I, Fukumura D, Miura S, Suematsu M, Suzuki M, Sekizuka E, Nagata H, Morishita T, Tsuchiya M
Fluorographic study on the oxidative stress in the process of gastric mucosal injury: attenuating effect of vitamin E.
J Gastroenterol Hepatol. 1993;8(3):254-8 - PMID: 8518396
Kurose I, Miura S, Fukumura D, Yonei Y, Saito H, Tada S, Suematsu M, Tsuchiya M
Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: a comparison with oxidative burst.
Cancer Res. 1993;53(11):2676-82 - PMID: 8388320
Zlotecki RA, Boucher Y, Lee I, Baxter LT, Jain RK
Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.
Cancer Res. 1993;53(11):2466-8 - PMID: 8495405
Kurose I, Fukumura D, Miura S, Sekizuka E, Nagata H, Suematsu M, Tsuchiya M
Nitric oxide mediates vasoactive effects of endothelin-3 on rat mesenteric microvascular beds in vivo.
Angiology. 1993;44(6):483-90 - PMID: 8503515 - DOI: 10.1177/000331979304400609
Boucher Y, Pollin B, Azérad J
Microinfusions of excitatory amino acid antagonists into the trigeminal sensory complex antagonize the jaw opening reflex in freely moving rats.
Brain Res. 1993;614(1-2):155-63 - PMID: 8102311
Kurose I, Kato S, Ishii H, Fukumura D, Miura S, Suematsu M, Tsuchiya M
Nitric oxide mediates lipopolysaccharide-induced alteration of mitochondrial function in cultured hepatocytes and isolated perfused liver.
Hepatology. 1993;18(2):380-8 - PMID: 8340067
Kristjansen PE, Boucher Y, Jain RK
Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.
Cancer Res. 1993;53(20):4764-6 - PMID: 8402656
Kurose I, Miura S, Fukumura D, Tsuchiya M
Mechanisms of endothelin-induced macromolecular leakage in microvascular beds of rat mesentery.
Eur J Pharmacol. 1993;250(1):85-94 - PMID: 8119327
Leunig M, Goetz AE, Dellian M, Zetterer G, Gamarra F, Jain RK, Messmer K
Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.
Cancer Res. 1992;52(2):487-90 - PMID: 1728421
Kaufman EN, Jain RK
Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Cancer Res. 1992;52(15):4157-67 - PMID: 1638531
Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, Jain RK
Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.
Cancer Res. 1992;52(7):1993-5 - PMID: 1551128
Eskey CJ, Koretsky AP, Domach MM, Jain RK
2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.
Cancer Res. 1992;52(21):6010-9 - PMID: 1394226
Baxter LT, Yuan F, Jain RK
Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Cancer Res. 1992;52(20):5838-44 - PMID: 1394212
Kaufman EN, Jain RK
In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching.
J Immunol Methods. 1992;155(1):1-17 - PMID: 1383343
Kurose I, Miura S, Suematsu M, Serizawa H, Fukumura D, Asako H, Hibi T, Tsuchiya M
Tissue-type plasminogen activator of colonic mucosa in ulcerative colitis. Evidence of endothelium-derived fibrinolytic activation.
Dig Dis Sci. 1992;37(2):307-11 - PMID: 1735352
Saito H, Fukumura D, Kurose I, Suematsu M, Tada S, Kagawa T, Miura S, Morizane T, Tsuchiya M
Visualization of oxidative processes at the cellular level during neutrophil-mediated cytotoxicity against a human hepatoma cell line, HCC-M.
Int J Cancer. 1992;51(1):124-9 - PMID: 1314229
Lee I, Boucher Y, Jain RK
Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
Cancer Res. 1992;52(11):3237-40 - PMID: 1534273
Kurose I, Miura S, Fukumura D, Tashiro H, Imaeda H, Shiozaki H, Suematsu M, Nagata H, Sekizuka E, Tsuchiya M
Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1.
Gut. 1992;33(7):868-71 - PMID: 1644323 - PMCID: PMC1379395
Shimmura S, Tsubota K, Oguchi Y, Fukumura D, Suematsu M, Tsuchiya M
Oxiradical-dependent photoemission induced by a phacoemulsification probe.
Invest Ophthalmol Vis Sci. 1992;33(10):2904-7 - PMID: 1326494
Liu YY, Miura S, Suzuki H, Kurose I, Fukumura D, Suzuki M, Suematsu M, Tsuchiya M
Quantitative analysis of mesenteric microcirculatory disturbances induced by autonomic nervous irritation.
Keio J Med. 1992;41(3):128-33 - PMID: 1434306
Boucher Y, Jain RK
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.
Cancer Res. 1992;52(18):5110-4 - PMID: 1516068
Suzuki M, Miura S, Suematsu M, Fukumura D, Kurose I, Suzuki H, Kai A, Kudoh Y, Ohashi M, Tsuchiya M
Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury.
Am J Physiol. 1992;263(5 Pt 1):G719-25 - PMID: 1443147 - DOI: 10.1152/ajpgi.1992.263.5.G719
Less JR, Posner MC, Boucher Y, Borochovitz D, Wolmark N, Jain RK
Interstitial hypertension in human breast and colorectal tumors.
Cancer Res. 1992;52(22):6371-4 - PMID: 1423283
Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, Jain RK
Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.
Cancer Res. 1992;52(23):6553-60 - PMID: 1384965
Ward KA, Jain RK
Blood Flow Response to Hyperglycemia.
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Sevick EM, Jain RK
Viscous Resistance to Blood Flow in the Tumor Microcirculation: Clinical Implications.
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Baxter LT, Jain RK
Vascular and Interstitial Transport in Tumors
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Jain RK
Parameters Governing Tumor Blood Flow
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Ward KA, DiPette DJ, Held TN, Jain RK
Effect of intravenous versus intraperitoneal glucose injection on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1991;51(13):3612-6 - PMID: 2054796
Baxter LT, Jain RK
Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.
Microvasc Res. 1991;41(2):252-72 - PMID: 2051960
Baxter LT, Jain RK
Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.
Microvasc Res. 1991;41(1):5-23 - PMID: 2051954
Sasaki A, Melder RJ, Whiteside TL, Herberman RB, Jain RK
Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.
J Natl Cancer Inst. 1991;83(6):433-7 - PMID: 1999850
Sevick EM, Jain RK
Measurement of capillary filtration coefficient in a solid tumor.
Cancer Res. 1991;51(4):1352-5 - PMID: 1997172
Jain RK
Therapeutic implications of tumor physiology.
Curr Opin Oncol. 1991;3(6):1105-8 - PMID: 1843113
Jain RK
Haemodynamic and transport barriers to the treatment of solid tumours.
Int J Radiat Biol. 1991;60(1-2):85-100 - PMID: 1678003
Kaufman EN, Jain RK
Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime.
Biophys J. 1991;60(3):596-610 - PMID: 1932550 - PMCID: PMC1260103 - DOI: 10.1016/S0006-3495(91)82089-6
Huang P
[Xenograft of human nasopharyngeal mucosa in nude mice].
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1991;24(4):219-20, 255 - PMID: 2486076
Huang P
[Adult nasopharyngeal mucosa xenograft and dinitrosopiperazine carcinogenesis in nude mice].
Zhonghua Yi Xue Za Zhi. 1991;71(8):441-3, 32 - PMID: 1660764
Miura S, Kurose I, Fukumura D, Suematsu M, Sekizuka E, Tashiro H, Serizawa H, Asako H, Tsuchiya M
Ischemic bowel necrosis induced by endothelin-1: an experimental model in rats.
Digestion. 1991;48(3):163-72 - PMID: 1916037 - DOI: 10.1159/000200689
Kurose I, Saito H, Suematsu M, Fukumura D, Miura S, Morizane T, Tsuchiya M
Kupffer cell-mediated oxidative stress on colon cancer cell line visualized by digital imaging fluorescence microscopy.
Cancer Lett. 1991;59(3):201-9 - PMID: 1913616
Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK
Interstitial hypertension in superficial metastatic melanomas in humans.
Cancer Res. 1991;51(24):6691-4 - PMID: 1742743
Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK
Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.
Cancer Res. 1991;51(24):6695-8 - PMID: 1742744
Yuan F, Baxter LT, Jain RK
Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Cancer Res. 1991;51(12):3119-30 - PMID: 2039991
Sevick EM, Jain RK
Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Cancer Res. 1991;51(10):2727-30 - PMID: 2021951
Ohkubo C, Bigos D, Jain RK
Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.
Cancer Res. 1991;51(5):1561-3 - PMID: 1997196
Less JR, Skalak TC, Sevick EM, Jain RK
Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
Cancer Res. 1991;51(1):265-73 - PMID: 1988088
Herberman RB, Basse P, Jain RK, Melder RJ, Goldfarb RH, Ernstoff MS, Kirkwood JM, Whiteside TL
Approaches to immunotherapy with defined populations of IL-2 cultured NK cells, immune T Cells or tumor infiltrating lymphocytes.
In: Biology and Clinical Applications of IL-2, R.C. Rees, Ed., Oxford University Press, London. 1990;Chapter 12:111-119
Jain RK
Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.
Cancer Res. 1990;50(3 Suppl):814s-819s - PMID: 2404582
Clauss MA, Jain RK
Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Cancer Res. 1990;50(12):3487-92 - PMID: 2340499
Jain RK
Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Cancer Metastasis Rev. 1990;9(3):253-66 - PMID: 2292138
Kaufman EN, Jain RK
Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.
Biophys J. 1990;58(4):873-85 - PMID: 2248992 - PMCID: PMC1281033 - DOI: 10.1016/S0006-3495(90)82432-2
Jain RK
Tumor physiology and antibody delivery.
Front Radiat Ther Oncol. 1990;24:32-46; discussion 64-8 - PMID: 2187763
Guan EN, Zhou TC, Wang JH, Chen Y, Sun YX, Huang PG, Tang WP, Zhao ML
Effects of monoclonal antibody anti-EGF receptor on human nasopharyngeal carcinoma cell and other tumor cells.
Sci China B. 1990;33(11):1334-40 - PMID: 2095159
Boucher Y, Baxter LT, Jain RK
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer Res. 1990;50(15):4478-84 - PMID: 2369726
Jain RK, Stock RJ, Chary SR, Rueter M
Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.
Microvasc Res. 1990;39(1):77-93 - PMID: 2314308 - DOI: 10.1016/0026-2862(90)90060-5
Baxter LT, Jain RK
Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Microvasc Res. 1990;40(2):246-63 - PMID: 2250603 - DOI: 10.1016/0026-2862(90)90023-k
Chary SR, Jain RK
Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.
Proc Natl Acad Sci U S A. 1989;86(14):5385-9 - PMID: 2748592 - PMCID: PMC297627
Sevick EM, Jain RK
Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.
Cancer Res. 1989;49(13):3506-12 - PMID: 2731172
Jain RK
Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
J Natl Cancer Inst. 1989;81(8):570-6 - PMID: 2649688
Baxter LT, Jain RK
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Microvasc Res. 1989;37(1):77-104 - PMID: 2646512
Guan E, Zhou TC, Wang JH, Huang PG, Tang WP, Zhao ML, Chen Y, Sun YX
Growth inhibition of human nasopharyngeal carcinoma in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies.
Int J Cell Cloning. 1989;7(4):242-56 - PMID: 2768842 - DOI: 10.1002/stem.5530070406
Sevick EM, Jain RK
Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.
Cancer Res. 1989;49(13):3513-9 - PMID: 2731173
Sasaki A, Jain RK, Maghazachi AA, Goldfarb RH, Herberman RB
Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.
Cancer Res. 1989;49(14):3742-6 - PMID: 2500233
Garkavtsev IV, Tsvetkova TG, Yegolina NA, Gudkov AV
Variability of human rRNA genes: inheritance and nonrandom chromosomal distribution of structural variants of nontranscribed spacer sequences.
Hum Genet. 1988;81(1):31-7 - PMID: 3198124
Maldarelli C, Jain RK
Stability of thin films: characterization and applications in industrial and biological systems.
Thin Liquid Films, I.B. Ivanov, Ed., M. Dekker, New York. 1988;:497-568
Jain RK
Transvascular and interstitial transport in tumors
Vascular Endothelium in Health and Disease, S. Chien (Ed.), Elsevier, Amsterdam . 1988;:215-220
Jain RK
Transport of molecules across tumor vasculature.
Cancer Metastasis Rev. 1988;6(4):559-93 - PMID: 3327633
Ward KA, Jain RK
Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia.
Int J Hyperthermia. 1988;4(3):223-50 - PMID: 3290346
Jain RK
Determinants of tumor blood flow: a review.
Cancer Res. 1988;48(10):2641-58 - PMID: 3282647
Tang WP, Huang PG, Zhao ML, Liao SL, Zeng Y
Wikstroemia indica promotes development of nasopharyngeal carcinoma in rats initiated by dinitrosopiperazine.
J Cancer Res Clin Oncol. 1988;114(4):429-31 - PMID: 3410882
DiPette DJ, Ward KA, Jain RK, Kerr NE, Schwarzenberger K
Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1988;48(6):1476-80 - PMID: 3345521
Sevick EM, Jain RK
Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.
Cancer Res. 1988;48(5):1201-7 - PMID: 3342400
Jain RK, Baxter LT
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Cancer Res. 1988;48(24 Pt 1):7022-32 - PMID: 3191477
Baxter LT, Jain RK
Vascular permeability and interstitial diffusion in superfused tissues: a two-dimensional model.
Microvasc Res. 1988;36(1):108-15 - PMID: 3185299 - DOI: 10.1016/0026-2862(88)90043-x
Jain RK
Tumor blood flow response to hyperthermia and pharmacological agents.
Radiation Research, E.M. Fieldman et al (eds.), Taylor and Francis, London. 1987;Volume 2:813-818
Jain RK
Interstitial transport in tumors.
Advances in Microcirculation. 1987;13:266-284
Chary SC, Jain RK
Analysis of diffusive and convective recovery after photobleaching-uniform flow field.
Chemical Engineering Commun. 1987;55:235-249
Ward-Hartley KA, Jain RK
Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.
Cancer Res. 1987;47(2):371-7 - PMID: 3791228
Traykov TT, Jain RK
Effect of glucose and galactose on red blood cell membrane deformability.
Int J Microcirc Clin Exp. 1987;6(1):35-44 - PMID: 3583577
Baxter LT, Jain RK, Svensjö E
Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.
Microvasc Res. 1987;34(3):336-48 - PMID: 2448593
Jain RK, Ward-Hartley KA
Dynamics of cancer cell interactions with microvasculature and interstitium.
Biorheology. 1987;24(2):117-25 - PMID: 3651585 - DOI: 10.3233/bir-1987-24205
Jain RK
Transport of molecules in the tumor interstitium: a review.
Cancer Res. 1987;47(12):3039-51 - PMID: 3555767
DiPette D, Ward-Hartley K, Jain RK
Effect of hyperglycemia on systemic hemodynamics and blood flow rate in normal and neoplastic tissues in rats
Cancer Res. 1986;46:6299-6304
Traykov TT, Jain RK
Effect of transmembrane potential on the deformability of RBC's suspended in carbohydrate-saline solutions.
J Colloid and Interface Science. 1986;114:273-276
Traykov TT, Jain RK
Effect of glucose, galactose, and transmembrane potential on shear elastic modulus of erythrocyte membrane.
AIChE Symposium Series. 1986;82:190-194
Gerlowski LE, Jain RK
Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.
Int J Microcirc Clin Exp. 1986;4(4):363-72 - PMID: 4086191
Jain RK, Gerlowski LE
Extravascular transport in normal and tumor tissues.
Crit Rev Oncol Hematol. 1986;5(2):115-70 - PMID: 3521923
DiPette DJ, Ward-Hartley KA, Jain RK
Effect of glucose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1986;46(12 Pt 1):6299-304 - PMID: 3779648
Gerlowski LE, Jain RK
Microvascular permeability of normal and neoplastic tissues.
Microvasc Res. 1986;31(3):288-305 - PMID: 2423854 - DOI: 10.1016/0026-2862(86)90018-x
Jain RK
Analysis of heat transfer and temperature distributions in tissues during local and whole body hyperthermia
Heat Transfer in Medicine and Biology, A. Shitzer and R. Eberhart, Eds., Plenum Press, New York, Volume 2. 1985;Chapter 16:3-54
Ivanov B, Dimitrov DS, Somasundaran P, Jain RK
Thinning of films with deformable surfaces: diffusion-controlled surfactant transfer
Chemical Engineering Science. 1985;40:137-150
Dimitrov DS, Zhelev DV, Jain RK
Stability of membrane systems modeled as multilayered viscoelastic films.
J Theor Biol. 1985;113(2):353-77 - PMID: 3999781
Boucher Y, Roberge S, Roy PE
Ultrastructural comparative study on lymphatic capillaries of the subendocardium, myocardium, and subepicardium of the heart left ventricle.
Microvasc Res. 1985;29(3):305-19 - PMID: 3999989
Roberge S, Boucher Y, Roy PE
Transient ultrastructural variations of pulmonary lymphatic capillaries during the respiratory cycle of the rat lung.
Anat Rec. 1985;213(4):551-9 - PMID: 4083535 - DOI: 10.1002/ar.1092130411
Jain RK
Transport of macromolecules in tumor microcirculation.
Biotechnol Prog. 1985;1(2):81-94 - PMID: 20568145 - DOI: 10.1002/btpr.5420010205
Jain RK
Mass and heat transfer in tumors: applications in detection and treatment
Advances in Transport Processes. 1984;3:205-339
Jain RK, Ward-Hartley KA
Tumor blood flow: characterization, modifications and role in hyperthermia
IEEE Transactions in Sonics and Ultrasonics; Special Issue on Hyperthermia. 1984;31:504-526
Dimitrov DS, Jain RK
Stability of thin viscoelastic films between permeable membranes
J Colloid and Interface Science. 1984;101:489-499
Dimitrov DS, Li J, Angelova M, Jain RK
Surface effects in preparation of cell-size liposomes.
FEBS Letters. 1984;176:398-400
Dudar TE, Jain RK
Differential response of normal and tumor microcirculation to hyperthermia.
Cancer Res. 1984;44(2):605-12 - PMID: 6692365
Peloso R, Tuma DT, Jain RK
Dielectric properties of solid tumors during normothermia and hyperthermia.
IEEE Trans Biomed Eng. 1984;31(11):725-8 - PMID: 6500596 - DOI: 10.1109/TBME.1984.325399
Dimitrov DS, Jain RK
Membrane stability.
Biochim Biophys Acta. 1984;779(4):437-68 - PMID: 6391549
Nugent LJ, Jain RK
Extravascular diffusion in normal and neoplastic tissues.
Cancer Res. 1984;44(1):238-44 - PMID: 6197161
Nugent LJ, Jain RK
Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed.
Am J Physiol. 1984;246(1 Pt 2):H129-37 - PMID: 6198927 - DOI: 10.1152/ajpheart.1984.246.1.H129
Jain RK, Shah SA, Finney PL
Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia.
J Natl Cancer Inst. 1984;73(2):429-36 - PMID: 6589435 - DOI: 10.1093/jnci/73.2.429
Nugent LJ, Jain RK
Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues.
Microvasc Res. 1984;28(2):270-4 - PMID: 6209533 - DOI: 10.1016/0026-2862(84)90022-0
Nugent LJ, Jain RK
Two-compartment model for plasma pharmacokinetics in individual blood vessels.
J Pharmacokinet Biopharm. 1984;12(4):451-61 - PMID: 6084709 - DOI: 10.1007/bf01062668
Jain RK
Bioheat transfer: mathematical models of thermal systems.
Hyperthermia in Cancer Therapy, F.K. Storm, Ed., G.K. Hall and Co., Boston. 1983;Chapter 2:9-46
Dudar TE, Jain RK
Mathematical models for microcirculatory changes during hyperthermia in normal and neoplastic tissues
AIChE Symposium Series 227. 1983;79:153-162
Nugent LJ, Jain RK
Interstitial diffusion of macromolecules in normal and tumor capillary beds
AIChE Symposium Series 227. 1983;79:1-10
Jain RK, Maldarelli C
Stability of thin viscoelastic films with applications to biological membrane deformation.
Annals of New York Academy of Sciences. 1983;404:89-102
Volpe BT, Jain RK
Temperature distributions and thermal response in humans. II. Simulation of whole-body, regional and localized hyperthermia in cancer patients
AIChE Symposium Series 227. 1983;79:116-123
Shah SA, Jain RK, Finney PL
Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma.
Adv Exp Med Biol. 1983;157:23-42 - PMID: 7158522
Dudar TE, Jain RK
Microcirculatory flow changes during tissue growth.
Microvasc Res. 1983;25(1):1-21 - PMID: 6188025
Shah SA, Jain RK, Finney PL
Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma.
Cancer Lett. 1983;19(3):317-23 - PMID: 6883314
Gerlowski LE, Jain RK
Physiologically based pharmacokinetic modeling: principles and applications.
J Pharm Sci. 1983;72(10):1103-27 - PMID: 6358460
Shah SA, Jain RK, Finney PL
Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rats bearing W256 carcinosarcoma
Hyperthermia, H.I. Bicher and D.F. Bruley, eds., Plenum Publishing Corporation, New York. 1982;:23-42
Maldarelli C, Jain RK
The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film II. Extension of the theory to the study of the onset of small-scale cell membrane motions.
J. Colloid and Interface Science. 1982;90:263-276
Maldarelli C, Jain RK
The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. I. General formulation and a derivation of the dispersion equation.
J. Colloid and Interface Science. 1982;90:233-262
Grossmann IE, Drabbant RD, Jain RK
Incorporating toxicology in the synthesis of industrial chemical complexes
Chemical Engineering Commun. 1982;17:151-170
Townsend JG, Jain RK, Cashmore AR
In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.
J Pharm Sci. 1982;71(10):1102-5 - PMID: 7143204
Gullino PM, Jain RK, Grantham FH
Temperature gradients and local perfusion in a mammary carcinoma.
J Natl Cancer Inst. 1982;68(3):519-33 - PMID: 6950181
Volpe BT, Jain RK
Temperature distributions and thermal response in humans. I. Simulations of various modes of whole-body hyperthermia in normal subjects.
Med Phys. 1982;9(4):506-13 - PMID: 7110081 - DOI: 10.1118/1.595115
Nugent LJ, Jain RK
Monitoring transport in the rabbit ear chamber.
Microvasc Res. 1982;24(2):204-9 - PMID: 7176939
Jain RK, Gerlowski L, Weissbrod J, Wang J, Pierson RN, Jr
Kinetics of uptake, distribution and excretion of zinc in rats.
Annals of Biomedical Engineering. 1981;9:347-361
Zawicki DF, Jain RK, Schmid-Schoenbein GW, Chien S
Dynamics of neovascularization in normal tissue.
Microvasc Res. 1981;21(1):27-47 - PMID: 7010086
Jain RK, Weissbrod JM, Wei J
Mass transport in tumors: characterization and applications to chemotherapy.
Adv Cancer Res. 1981;33:251-310 - PMID: 7006335 - DOI: 10.1016/s0065-230x(08)60672-7
Jain RK
Heat transfer in tumors: characterization and applications to thermography and hyperthermia.
Advances in Biomedical Engineering, edited by D.O. Cooney, Marcel Dekker, Inc., New York, Part I. 1980;Chapter 2:59-91
Jain RK, Ivanov IB
Thinning and rupture of ring-shaped films
J Chemical Society, Faraday Transactions II. 1980;76:250-266
Sien HP, Jain RK
Intratumour temperature distributions during hyperthermia
J Thermal Biology. 1980;5:127-130
Jain RK, Gullino PM
Analysis of transient temperature distribution in a perfused medium Due to a spherical heat source with application to heat transfer in tumors: homogeneous and infinite medium
Chemical Engineering Commun. 1980;4:95-118
Maldarelli C, Jain RK, Ivanov IB, Ruckenstein E
Stability of symmetric and unsymmetric, thin liquid films to short and long wavelength perturbations
J Colloid and Interface Science. 1980;78:118-143
Jain RK
Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia.
Ann N Y Acad Sci. 1980;335:48-66 - PMID: 6931539
Weissbrod JM, Jain RK
Preliminary model for streptozocin metabolism in mice.
J Pharm Sci. 1980;69(6):691-4 - PMID: 6451687
Chryanthopoulos GS, Jain RK
Thermal interactions between normal and neoplastic tissues in the rat, rabbit, swine, and dog during hyperthermia.
Med Phys. 1980;7(5):529-39 - PMID: 7421764 - DOI: 10.1118/1.594668
Ivanov IB, Jain RK, Somasundaran P, Traykov TT
The role of surfactants on the coalescences of emulsion droplets
Solution Chemistry of Surfactants, edited by K.A. Mittal, Plenum Press, New York. 1979;2:817-840
Jain RK, Ivanov IB, Maldarelli C, Ruckenstein E
Instability and rupture of thin liquid films
Dynamics and Instability of Fluid Interfaces, edited by T.S. Sorensen, Springer-Verlag, New York. 1979;:140-167
Ivanov IB, Jain RK
Formation and thinning of thin liquid films
Dynamics and Instability of Fluid Interfaces, edited by T.S. Sorensen, Springer-Verlag, New York. 1979;:120-139
Jain RK
Transient temperature distributions in an infinite perfused medium due to a time-dependent, spherical heat source
Trans. ASME J. Biomechanical Engineering. 1979;101:82-86
Tzeghai G, Jain RK
A semi-empirical model for cell kill kinetics during hyperthermia.
J Thermal Biology. 1979;4:257-258
Sien HP, Jain RK
Temperature distributions in normal and neoplastic tissues during hyperthermia: a lumped parameter model
J Thermal Biology. 1979;4:157-164
Jain RK, Wei J, Gullino PM
Pharmacokinetics of methotrexate in solid tumors.
J Pharmacokinet Biopharm. 1979;7(2):181-94 - PMID: 20218013
Jain RK, Grantham FH, Gullino PM
Blood flow and heat transfer in Walker 256 mammary carcinoma.
J Natl Cancer Inst. 1979;62(4):927-33 - PMID: 285296
Jain RK, Maldarelli C, Ruckenstein E
Onset of microvilli in normal and neoplastic cells.
AIChE Symposium Series, Biorheology. 1978;74:120-124
Jain RK
Effect of inhomogeneities and finite boundaries on temperature distribution in a perfused medium with application to tumors
Trans. ASME J. Biomechanical Engineering. 1978;100:235-241
Weissbrod JM, Jain RK, Sirotnak FM
Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.
J Pharmacokinet Biopharm. 1978;6(6):487-503 - PMID: 731413
Pierson RN, Price DC, Wang J, Jain RK
Extracellular water measurements: organ tracer kinetics of bromide and sucrose in rats and man.
Am J Physiol. 1978;235(3):F254-64 - PMID: 696835 - DOI: 10.1152/ajprenal.1978.235.3.F254
Jain RK, Wei J
Dynamics of drug transport in solid tumors: distributed parameter model
J Bioengineering. 1977;1:313-329
Jain RK, Denn MM
Short term regulation of BOD upsets in an estuary
Trans. ASME J. Dynamic Systems, Measurement and Control. 1976;98, Series G:30-31
Jain RK, Ruckenstein E
Stability of stagnant viscous films on a solid surface
J Colloid and Interface Science. 1976;54:108-116
Ruckenstein E, Jain RK
Spontaneous rupture of thin liquid films
J Chemical Society, Faraday Transactions II. 1974;70:132-147
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