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Chamseddine I, Kim Y, De B, El Naqa I, Duda DG, Wolfgang J, Pursley J, Paganetti H, Wo J, Hong T, Koay EJ, Grassberger C
Predictive Modeling of Survival and Toxicity in Patients With Hepatocellular Carcinoma After Radiotherapy.
JCO Clin Cancer Inform. 2022;6:e2100169 - PMID: 35192402 - PMCID: PMC8863122 - DOI: 10.1200/CCI.21.00169
Xiao Y, Chen J, Zhou H, Zeng X, Ruan Z, Pu Z, Jiang X, Matsui A, Zhu L, Amoozgar Z, Chen DS, Han X, Duda DG, Shi J
Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy.
Nat Commun. 2022;13(1):758 - PMID: 35140208 - PMCID: PMC8828745 - DOI: 10.1038/s41467-022-28279-8
Jones D, Wang Z, Chen I, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, Van Wijnbergen JW, Pereira E, Vakoc B, Huang P, Nia H, Padera T
Solid stress impairs lymphocyte infiltration into lymph node metastases.
FASEB J. 2022;36 Suppl 1:ePub - PMID: 35557097 - DOI: 10.1096/fasebj.2022.36.S1.R4616
Drobni ZD, Michielin O, Quinaglia T, Zlotoff DA, Zubiri L, Gilman HK, Supraja S, Merkely B, Muller V, Sullivan RJ, Reynolds KL, Pittet MJ, Jain RK, Neilan TG
Renin–angiotensin–aldosterone system inhibitors and survival in patients with hypertension treated with immune checkpoint inhibitors
European Journal of Cancer. 2022;163:108-118 - PMID: 35065368 - PMCID: PMC9618285 - DOI: 10.1016/j.ejca.2021.12.024
Subudhi S, Voutouri C, Hardin CC, Nikmaneshi MR, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Jain RK, Munn LL
Strategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling
EBioMedicine. 2022;75:103809 - PMID: 35033853 - PMCID: PMC8757652 - DOI: 10.1016/j.ebiom.2021.103809
Blanc L, Ferraro GB, Tuck M, Prideaux B, Dartois V, Jain RK, Desbenoit N
Kendrick Mass Defect Variation to Decipher Isotopic Labeling in Brain Metastases Studied by Mass Spectrometry Imaging.
Anal Chem. 2021;93(49):16314-16319 - PMID: 34860501 - PMCID: PMC9841243 - DOI: 10.1021/acs.analchem.1c03916
Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, Irvine DJ
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity.
Sci Immunol. 2021;6(66):eabf1152 - PMID: 34860581 - PMCID: PMC8763571 - DOI: 10.1126/sciimmunol.abf1152
Gkika E, Adebahr S, Brenner A, Schimek-Jasch T, Radicioni G, Exner JP, Rühle A, Spohn SKB, Popp I, Zamboglou C, Sprave T, Firat E, Niedermann G, Nicolay NH, Nestle U, Grosu AL, Duda DG
Changes in Blood Biomarkers of Angiogenesis and Immune Modulation after Radiation Therapy and Their Association with Outcomes in Thoracic Malignancies.
Cancers (Basel). 2021;13(22):ePub - PMID: 34830880 - PMCID: PMC8616228 - DOI: 10.3390/cancers13225725
Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, Deik A, Petronio L, Tang AA, Zhu C, Wang L, Rosenberg D, Mangena V, Roth J, Chung K, Jain RK, Clish CB, Vander Heiden MG, Golub TR
Publisher Correction: A metastasis map of human cancer cell lines.
Nature. 2021;599(7885):E7 - PMID: 34732899 - PMCID: PMC8599020 - DOI: 10.1038/s41586-021-04149-z
Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118
Klein S, Duda DG
Machine Learning for Future Subtyping of the Tumor Microenvironment of Gastro-Esophageal Adenocarcinomas.
Cancers (Basel). 2021;13(19):ePub - PMID: 34638408 - PMCID: PMC8507866 - DOI: 10.3390/cancers13194919
Keahey P, Si P, Razavi M, Yu S, Lippok N, Villiger M, Padera TP, de la Zerda A, Bouma B
Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.
Nano Lett. 2021;21(20):8595-8601 - PMID: 34644094 - PMCID: PMC8555503 - DOI: 10.1021/acs.nanolett.1c02291
Munoz NM, Dupuis C, Williams M, Dixon K, McWatters A, Zhang J, Pavuluri S, Rao A, Duda DG, Kaseb A, Sheth RA
Immune modulation by molecularly targeted photothermal ablation in a mouse model of advanced hepatocellular carcinoma and cirrhosis.
Sci Rep. 2022;12(1):14449 - PMID: 36002545 - PMCID: PMC9402568 - DOI: 10.1038/s41598-022-15948-3
Li H, Wei H, Padera TP, Baish JW, Munn LL
Computational simulations of the effects of gravity on lymphatic transport.
PNAS Nexus. 2022;1(5):pgac237 - PMID: 36712369 - PMCID: PMC9802413 - DOI: 10.1093/pnasnexus/pgac237
Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Stylianopoulos T, Munn LL, Jain RK
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2.
Proc Natl Acad Sci U S A. 2023;120(3):e2211132120 - PMID: 36623200 - PMCID: PMC9934028 - DOI: 10.1073/pnas.2211132120
Chen S, Huang C, Liao G, Sun H, Xie Y, Liao C, Wang J, He M, Hu H, Dai Z, Ren X, Zeng X, Lin Z, Zhang GP, Xie W, Shen S, Li S, Peng S, Kuang DM, Zhao Q, Duda DG, Kuang M
Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences.
Gut. 2023;72(6):1196-1210 - PMID: 36596711 - DOI: 10.1136/gutjnl-2022-328428
Mohamed YI, Duda DG, Awiwi MO, Lee SS, Altameemi L, Xiao L, Morris JS, Wolff RA, Elsayes KM, Hatia RI, Qayyum A, Chamseddine SM, Rashid A, Yao JC, Mahvash A, Hassan MM, Amin HM, Kaseb AO
Plasma growth hormone is a potential biomarker of response to atezolizumab and bevacizumab in advanced hepatocellular carcinoma patients.
Oncotarget. 2022;13:1314-1321 - PMID: 36473155 - PMCID: PMC9726202 - DOI: 10.18632/oncotarget.28322
Sasaki T, Shigeta K, Kitahara S, Suzuki Y, Matsui S, Seishima R, Okabayashi K, Duda DG, Kitagawa Y
Inhibition of STAT3 Promotes Effector T Cell Infiltration But also Immunosuppression in the HCC Tumor Microenvironment.
Anticancer Res. 2022;42(11):5205-5215 - PMID: 36288859 - DOI: 10.21873/anticanres.16027
Duda DG, Jain RK
Revisiting Antiangiogenic Multikinase Inhibitors in the Era of Immune Checkpoint Blockade: The Case of Sorafenib.
Cancer Res. 2022;82(20):3665-3667 - PMID: 36245248 - DOI: 10.1158/0008-5472.CAN-22-2639
Nagalo BM, Zhou Y, Loeuillard EJ, Dumbauld C, Barro O, Elliott NM, Baker AT, Arora M, Bogenberger JM, Meurice N, Petit J, Uson Junior PLS, Aslam F, Raupach E, Gabere M, Basnakian A, Simoes CC, Cannon MJ, Post SR, Buetow K, Chamcheu JC, Barrett MT, Duda DG, Jacobs B, Vile R, Barry MA, Roberts LR, Ilyas S, Borad MJ
Characterization of Morreton Virus (MORV) as a Novel Oncolytic Virotherapy Platform for Liver Cancers.
Hepatology. 2022;77(6):1943-1957 - PMID: 36052732 - DOI: 10.1002/hep.32769
Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S
Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy.
FASEB J. 2022;36(10):e22521 - PMID: 36052742 - PMCID: PMC9574655 - DOI: 10.1096/fj.202200033R
Dima SO, Dumitraşcu T, Popescu I, Duda DG
Using Molecular Subtyping of Pancreatic Ductal Adenocarcinoma for Multimodal Treatment Selection in Resectable Disease.
Chirurgia (Bucur). 2022;117(4):407-414 - PMID: 36049097 - DOI: 10.21614/chirurgia.2772
Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP
Solid stress impairs lymphocyte infiltration into lymph-node metastases.
Nat Biomed Eng. 2021;5(12):1426-1436 - PMID: 34282290 - PMCID: PMC8678215 - DOI: 10.1038/s41551-021-00766-1
Patel SA, Nilsson MB, Le X, Cascone T, Jain RK, Heymach JV
Molecular Mechanisms and Future Implications of VEGF/VEGFR in Cancer Therapy.
Clin Cancer Res. 2023;29(1):30-39 - PMID: 35969170 - PMCID: PMC10274152 - DOI: 10.1158/1078-0432.CCR-22-1366
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - PMCID: PMC10290535 - DOI: 10.1038/s41588-022-01134-8
How J, Ren S, Lombardi-Story J, Bergeron M, Foster J, Amrein PC, Brunner AM, Fathi AT, Hock H, Khachatryan A, Kikuchi H, Ng MR, Moran J, Narayan R, Neuberg D, Ramos A, Som T, Vartanian M, Chen YB, Duda DG, Hobbs GS
A nonrandomized phase I and biomarker trial of regorafenib in advanced myeloid malignancies.
EJHaem. 2022;3(2):434-442 - PMID: 35846042 - PMCID: PMC9175677 - DOI: 10.1002/jha2.408
Saulnier Sholler G, Duda DG, Bergendahl G, Ebb D, Snuderl M, Laetsch TW, Michlitsch J, Hanson D, Isakoff MS, Bielamowicz K, Kraveka JM, Ferguson W, Carmeliet P, De Deene A, Gijsen L, Jain RK
A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma.
Clin Cancer Res. 2022;28(18):3950-3957 - PMID: 35833850 - PMCID: PMC9481695 - DOI: 10.1158/1078-0432.CCR-22-1169
Ho WW, Pittet MJ, Fukumura D, Jain RK
The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy.
Cancer Cell. 2022;40(7):701-702 - PMID: 35714604 - PMCID: PMC10894502 - DOI: 10.1016/j.ccell.2022.05.016
Morita S, Duda DG
Refining genetic and molecular classifications to facilitate breakthrough treatments in intrahepatic cholangiocarcinoma: are we there yet?
Gut. 2022;72(4):608-610 - PMID: 35772925 - PMCID: PMC10435277 - DOI: 10.1136/gutjnl-2022-327782
Nuzzo PV, Adib E, Weise N, Curran C, Stewart T, Freeman D, Nassar AH, Abou Alaiwi S, Bakouny Z, McGregor BA, Choueiri TK, Jain RK, McKay RR, Sonpavde G
Impact of renin-angiotensin system inhibitors on outcomes in patients with metastatic renal cell carcinoma treated with immune-checkpoint inhibitors
Clin Genitourin Cancer. 2022;20(4):301-306 - PMID: 35614012 - PMCID: PMC10013974 - DOI: 10.1016/j.clgc.2022.04.012
van den Bent L, Frenkel NC, Poghosyan S, Molenaar IQ, Padera TP, Kranenburg O, Borel Rinkes IHM, Hagendoorn J
Liver lymphatic drainage patterns follow segmental anatomy.
Br J Surg. 2022;109(6):559-560 - PMID: 35576376 - PMCID: PMC10364678 - DOI: 10.1093/bjs/znac076
Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK
Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.
Clin Cancer Res. 2022;28(14):3076-3090 - PMID: 35584239 - PMCID: PMC9355624 - DOI: 10.1158/1078-0432.CCR-22-0486
Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.
Neoplasia. 2002;4(1):3-8 - PMID: 11922388 - PMCID: PMC1503314 - DOI: 10.1038/sj/neo/7900209
Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
Cancer Res. 2000;60(22):6248-52 - PMID: 11103778
Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Cancer Res. 2001;61(1):39-44 - PMID: 11196192
Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Proc Natl Acad Sci U S A. 2001;98(8):4628-33 - PMID: 11274375 - PMCID: PMC31885 - DOI: 10.1073/pnas.081626898
Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer Res. 2001;61(6):2404-8 - PMID: 11289105
Davies Cde L, Melder RJ, Munn LL, Mouta-Carreira C, Jain RK, Boucher Y
Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.
Microvasc Res. 2001;62(1):26-42 - PMID: 11421658 - DOI: 10.1006/mvre.2001.2311
Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Nat Med. 2001;7(7):864-8 - PMID: 11433354 - DOI: 10.1038/89997
Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
Cancer Res. 2001;61(16):6020-4 - PMID: 11507045
Tsuzuki Y, Mouta Carreira C, Bockhorn M, Xu L, Jain RK, Fukumura D
Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Lab Invest. 2001;81(10):1439-51 - PMID: 11598156 - DOI: 10.1038/labinvest.3780357
Xu L, Fukumura D, Jain RK
Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF.
J Biol Chem. 2002;277(13):11368-74 - PMID: 11741977 - DOI: 10.1074/jbc.M108347200
Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.
Am J Pathol. 2002;160(3):985-1000 - PMID: 11891196 - PMCID: PMC1867175 - DOI: 10.1016/S0002-9440(10)64920-6
Jain RK, Fenton BT
Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
J Natl Cancer Inst. 2002;94(6):417-21 - PMID: 11904313 - DOI: 10.1093/jnci/94.6.417
Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK
Tumour biology: herceptin acts as an anti-angiogenic cocktail.
Nature. 2002;416(6878):279-80 - PMID: 11907566 - DOI: 10.1038/416279b
Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer Res. 2000;60(19):5565-70 - PMID: 11034104
Dolmans DE, Kadambi A, Hill JS, Waters CA, Robinson BC, Walker JP, Fukumura D, Jain RK
Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Cancer Res. 2002;62(7):2151-6 - PMID: 11929837
Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK
Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.
Clin Cancer Res. 2002;8(4):1008-13 - PMID: 11948107
Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
Clin Cancer Res. 2002;8(4):1284-91 - PMID: 11948144
Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK
Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
Br J Cancer. 2002;86(6):947-53 - PMID: 11953828 - PMCID: PMC2364140 - DOI: 10.1038/sj.bjc.6600158
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