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Nugent LJ, Jain RK
Extravascular diffusion in normal and neoplastic tissues.
Cancer Res. 1984;44(1):238-44 - PMID: 6197161
Gerlowski LE, Jain RK
Physiologically based pharmacokinetic modeling: principles and applications.
J Pharm Sci. 1983;72(10):1103-27 - PMID: 6358460 - DOI: 10.1002/jps.2600721003
Shah SA, Jain RK, Finney PL
Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma.
Cancer Lett. 1983;19(3):317-23 - PMID: 6883314 - DOI: 10.1016/0304-3835(83)90101-5
Dudar TE, Jain RK
Microcirculatory flow changes during tissue growth.
Microvasc Res. 1983;25(1):1-21 - PMID: 6188025 - DOI: 10.1016/0026-2862(83)90040-7
Nugent LJ, Jain RK
Monitoring transport in the rabbit ear chamber.
Microvasc Res. 1982;24(2):204-9 - PMID: 7176939 - DOI: 10.1016/0026-2862(82)90057-7
Volpe BT, Jain RK
Temperature distributions and thermal response in humans. I. Simulations of various modes of whole-body hyperthermia in normal subjects.
Med Phys. 1982;9(4):506-13 - PMID: 7110081 - DOI: 10.1118/1.595115
Gullino PM, Jain RK, Grantham FH
Temperature gradients and local perfusion in a mammary carcinoma.
J Natl Cancer Inst. 1982;68(3):519-33 - PMID: 6950181
Shah SA, Jain RK, Finney PL
Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma.
Adv Exp Med Biol. 1983;157:23-42 - PMID: 7158522 - DOI: 10.1007/978-1-4684-4388-2_4
Zawicki DF, Jain RK, Schmid-Schoenbein GW, Chien S
Dynamics of neovascularization in normal tissue.
Microvasc Res. 1981;21(1):27-47 - PMID: 7010086 - DOI: 10.1016/0026-2862(81)90003-0
Chryanthopoulos GS, Jain RK
Thermal interactions between normal and neoplastic tissues in the rat, rabbit, swine, and dog during hyperthermia.
Med Phys. 1980;7(5):529-39 - PMID: 7421764 - DOI: 10.1118/1.594668
Weissbrod JM, Jain RK
Preliminary model for streptozocin metabolism in mice.
J Pharm Sci. 1980;69(6):691-4 - PMID: 6451687 - DOI: 10.1002/jps.2600690621
Jain RK, Grantham FH, Gullino PM
Blood flow and heat transfer in Walker 256 mammary carcinoma.
J Natl Cancer Inst. 1979;62(4):927-33 - PMID: 285296
Jain RK
Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia.
Ann N Y Acad Sci. 1980;335:48-66 - PMID: 6931539 - DOI: 10.1111/j.1749-6632.1980.tb50736.x
Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
Proc Natl Acad Sci U S A. 2013;110(31):12774-9 - PMID: 23861493 - PMCID: PMC3732948 - DOI: 10.1073/pnas.1310675110
Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK
Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164
Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, Mason W, Mikkelsen T, Phuphanich S, Ashby LS, Degroot J, Gattamaneni R, Cher L, Rosenthal M, Payer F, Jürgensmeier JM, Jain RK, Sorensen AG, Xu J, Liu Q, van den Bent M
Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma.
J Clin Oncol. 2013;31(26):3212-3218 - PMID: 23940216 - PMCID: PMC4021043 - DOI: 10.1200/JCO.2012.47.2464
Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
Nat Med. 2013;19(9):1178-83 - PMID: 23955713 - PMCID: PMC3769525 - DOI: 10.1038/nm.3289
Liao S, Padera TP
Lymphatic Function and Immune Regulation in Health and Disease.
Lymphat Res Biol. 2013;11(3):136-43 - PMID: 24024577 - PMCID: PMC3780287 - DOI: 10.1089/lrb.2013.0012
Qazi H, Palomino R, Shi ZD, Munn LL, Tarbell JM
Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion.
Integr Biol (Camb). 2013;5(11):1334-43 - PMID: 24077103 - PMCID: PMC4249644 - DOI: 10.1039/c3ib40057c
Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Nat Commun. 2013;4:2516 - PMID: 24084631 - PMCID: PMC3806395 - DOI: 10.1038/ncomms3516
Zhu AX, Finn RS, Mulcahy M, Gurtler J, Sun W, Schwartz JD, Dalal RP, Joshi A, Hozak RR, Xu Y, Ancukiewicz M, Jain RK, Nugent F, Duda DG, Stuart K
A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2 in Patients with Advanced Hepatocellular Cancer.
Clin Cancer Res. 2013;19(23):6614-23 - PMID: 24088738 - PMCID: PMC4795808 - DOI: 10.1158/1078-0432.CCR-13-1442
Lemon CM, Curtin PN, Somers RC, Greytak AB, Lanning RM, Jain RK, Bawendi MG, Nocera DG
Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.
Inorg Chem. 2014;53(4):1900-15 - PMID: 24143874 - PMCID: PMC3944830 - DOI: 10.1021/ic401587r
Chauhan VP, Jain RK
Strategies for advancing cancer nanomedicine.
Nat Mater. 2013;12(11):958-62 - PMID: 24150413 - PMCID: PMC4120281 - DOI: 10.1038/nmat3792
Stylianopoulos T, Jain RK
Combining two strategies to improve perfusion and drug delivery in solid tumors.
Proc Natl Acad Sci U S A. 2013;110(46):18632-7 - PMID: 24167277 - PMCID: PMC3832007 - DOI: 10.1073/pnas.1318415110
Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, Corcoran RB, Rivera MN, Ramaswamy S, Hung KE, Benes CH, Engelman JA
mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL inhibition by Suppressing MCL-1.
Cancer Discov. 2014;4(1):42-52 - PMID: 24163374 - PMCID: PMC3973435 - DOI: 10.1158/2159-8290.CD-13-0315
Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Proc Natl Acad Sci U S A. 2013;110(47):19059-64 - PMID: 24190997 - PMCID: PMC3839699 - DOI: 10.1073/pnas.1318022110
Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP
Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells.
Angiogenesis. 2014;17(2):419-27 - PMID: 24201897 - PMCID: PMC3981926 - DOI: 10.1007/s10456-013-9400-7
Hagendoorn J, Yock TI, Borel Rinkes IH, Padera TP, Ebb DH
Novel molecular pathways in Gorham disease: Implications for treatment.
Pediatr Blood Cancer. 2014;61(3):401-6 - PMID: 24214028 - PMCID: PMC4123459 - DOI: 10.1002/pbc.24832
Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK
Benefits of Vascular Normalization Are Dose and Time Dependent--Letter.
Cancer Res. 2013;73(23):7144-6 - PMID: 24265277 - PMCID: PMC3876035 - DOI: 10.1158/0008-5472.CAN-13-1989
Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK
Targeted therapy in rectal cancer.
Oncology (Williston Park). 2007;21(9):1055-65; discussion 1065, 1070, 1075 passim - PMID: 17910311 - PMCID: PMC2686129
Jain RK, Xu L
alphaPlGF: a new kid on the antiangiogenesis block.
Cell. 2007;131(3):443-5 - PMID: 17981110 - DOI: 10.1016/j.cell.2007.10.023
Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.
Blood. 2008;111(3):1302-5 - PMID: 17993613 - PMCID: PMC2214740 - DOI: 10.1182/blood-2007-06-094318
Mok W, Boucher Y, Jain RK
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107
Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT
Antiangiogenic agents for the treatment of glioblastoma.
Expert Opin Investig Drugs. 2007;16(12):1895-908 - PMID: 18041999 - DOI: 10.1517/13543784.16.12.1895
Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK
Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938 - DOI: 10.1593/neo.07643
Au P, Tam J, Fukumura D, Jain RK
Small blood vessel engineering.
Methods Mol Med. 2007;140:183-95 - PMID: 18085210 - DOI: 10.1007/978-1-59745-443-8_11
Munn LL, Dupin MM
Blood cell interactions and segregation in flow.
Ann Biomed Eng. 2008;36(4):534-44 - PMID: 18188702 - PMCID: PMC2752714 - DOI: 10.1007/s10439-007-9429-0
Jain RK
Taming vessels to treat cancer.
Sci Am. 2008;298(1):56-63 - PMID: 18225696 - DOI: 10.1038/scientificamerican0108-56
Au P, Tam J, Fukumura D, Jain RK
Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.
Blood. 2008;111(9):4551-8 - PMID: 18256324 - PMCID: PMC2343592 - DOI: 10.1182/blood-2007-10-118273
Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D
Perivascular nitric oxide gradients normalize tumor vasculature.
Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730
Jones RC, Capen D, Petersen B, Jain RK, Duda DG
A protocol for a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):378-87 - PMID: 18323809 - PMCID: PMC2676330 - DOI: 10.1038/nprot.2007.536
Jones RC, Capen DE, Cohen KS, Munn LL, Jain RK, Duda DG
A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):388-97 - PMID: 18323810 - PMCID: PMC2676340 - DOI: 10.1038/nprot.2007.537
Jain RK
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.
Nat Rev Cancer. 2008;8(4):309-16 - PMID: 18337733 - DOI: 10.1038/nrc2346
Nagano S, Perentes JY, Jain RK, Boucher Y
Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer Res. 2008;68(10):3795-802 - PMID: 18483263 - PMCID: PMC2871708 - DOI: 10.1158/0008-5472.CAN-07-6193
Huang P, Duda DG, Jain RK, Fukumura D
Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079
Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK
Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182
Padera TP, Jain RK
VEGFR3: a new target for antiangiogenesis therapy?
Dev Cell. 2008;15(2):178-9 - PMID: 18694556 - PMCID: PMC4790102 - DOI: 10.1016/j.devcel.2008.07.014
Sorensen AG, Batchelor TT, Wen PY, Zhang WT, Jain RK
Response criteria for glioma.
Nat Clin Pract Oncol. 2008;5(11):634-44 - PMID: 18711427 - PMCID: PMC4795821 - DOI: 10.1038/ncponc1204
Fukumura D, Jain RK
Imaging angiogenesis and the microenvironment.
APMIS. 2008;116(7-8):695-715 - PMID: 18834413 - PMCID: PMC2859845 - DOI: 10.1111/j.1600-0463.2008.01148.x
Gerstner ER, Sorensen AG, Jain RK, Batchelor TT
Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.
Curr Opin Neurol. 2008;21(6):728-35 - PMID: 18989120 - DOI: 10.1097/WCO.0b013e328318402a