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Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D
NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
J Clin Invest. 2005;115(7):1816-27 - PMID: 15951843 - PMCID: PMC1143589 - DOI: 10.1172/JCI24015
Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer Res. 2005;65(13):5674-82 - PMID: 15994941 - DOI: 10.1158/0008-5472.CAN-04-1682
Xu L, Tong R, Cochran DM, Jain RK
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Cancer Res. 2005;65(13):5711-9 - PMID: 15994946 - DOI: 10.1158/0008-5472.CAN-04-4313
di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL
Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
Cancer Res. 2005;65(13):5740-9 - PMID: 15994949 - DOI: 10.1158/0008-5472.CAN-04-4552
Jain RK, Au P, Tam J, Duda DG, Fukumura D
Engineering vascularized tissue.
Nat Biotechnol. 2005;23(7):821-3 - PMID: 16003365 - DOI: 10.1038/nbt0705-821
Huang P, McKee TD, Jain RK, Fukumura D
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comp Med. 2005;55(3):236-43 - PMID: 16089171
Forbes NS, Munn LL, Fukumura D, Jain RK
Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Cancer Res. 2003;63(17):5188-93 - PMID: 14500342
Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Cancer Res. 2002;62(23):6831-6 - PMID: 12460895
Jain RK
Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.
Semin Oncol. 2002;29(6 Suppl 16):3-9 - PMID: 12516032 - DOI: 10.1053/sonc.2002.37265
Mollica F, Jain RK, Netti PA
A model for temporal heterogeneities of tumor blood flow.
Microvasc Res. 2003;65(1):56-60 - PMID: 12535873 - DOI: 10.1016/s0026-2862(02)00012-2
Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD
Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Cancer Res. 2003;63(4):747-51 - PMID: 12591719
Dolmans DE, Fukumura D, Jain RK
Photodynamic therapy for cancer.
Nat Rev Cancer. 2003;3(5):380-7 - PMID: 12724736 - DOI: 10.1038/nrc1071
Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Nat Med. 2003;9(6):796-800 - PMID: 12754503 - DOI: 10.1038/nm879
Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RK
A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.
Blood. 2003;102(7):2555-61 - PMID: 12775571 - DOI: 10.1182/blood-2003-02-0365
Jain RK
Molecular regulation of vessel maturation.
Nat Med. 2003;9(6):685-93 - PMID: 12778167 - DOI: 10.1038/nm0603-685
Jain RK, Duda DG
Role of bone marrow-derived cells in tumor angiogenesis and treatment.
Cancer Cell. 2003;3(6):515-6 - PMID: 12842078 - DOI: 10.1016/s1535-6108(03)00138-7
Padera TP, Stoll BR, So PT, Jain RK
Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.
Mol Imaging. 2003;1(1):9-15 - PMID: 12920856 - DOI: 10.1162/15353500200200004
Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B
Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.
Microvasc Res. 2003;66(2):113-25 - PMID: 12935769 - DOI: 10.1016/s0026-2862(03)00039-6
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer Cell. 2005;8(2):131-41 - PMID: 16098466 - DOI: 10.1016/j.ccr.2005.07.003
Sunamura M, Duda DG, Ghattas MH, Lozonschi L, Motoi F, Yamauchi J, Matsuno S, Shibahara S, Abraham NG
Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.
Angiogenesis. 2003;6(1):15-24 - PMID: 14517400 - DOI: 10.1023/a:1025803600840
Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D
Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts.
Clin Cancer Res. 2003;9(11):4221-6 - PMID: 14519649
Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK
Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.
Circ Res. 2003;93(9):e88-97 - PMID: 14525808 - PMCID: PMC2755542 - DOI: 10.1161/01.RES.0000099243.20096.FA
Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, Abe T, Inoue H, Motoi F, Egawa S, Matsuno S, Horii A
Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.
Oncogene. 2003;22(44):6857-64 - PMID: 14534532 - DOI: 10.1038/sj.onc.1206751
Jain RK, Booth MF
What brings pericytes to tumor vessels?
J Clin Invest. 2003;112(8):1134-6 - PMID: 14561696 - PMCID: PMC213497 - DOI: 10.1172/JCI20087
Roose T, Netti PA, Munn LL, Boucher Y, Jain RK
Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled.
Microvasc Res. 2003;66(3):204-12 - PMID: 14609526 - DOI: 10.1016/s0026-2862(03)00057-8
Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.
Clin Cancer Res. 2003;9(15):5508-13 - PMID: 14654530
Padera TP, Boucher Y, Jain RK
Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Cancer Res. 2003;63(23):8555-6; author reply 8558 - PMID: 14679026
Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Nat Med. 2004;10(2):203-7 - PMID: 14716306 - DOI: 10.1038/nm981
Xu L, Pathak PS, Fukumura D
Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells.
Clin Cancer Res. 2004;10(2):701-7 - PMID: 14760093 - DOI: 10.1158/1078-0432.ccr-0953-03
Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK
Pathology: cancer cells compress intratumour vessels.
Nature. 2004;427(6976):695 - PMID: 14973470 - DOI: 10.1038/427695a
Kozin SV, Duda DG, Munn LL, Jain RK
Neovascularization After Irradiation: What is the Source of Newly Formed Vessels in Recurring Tumors?
J Natl Cancer Inst. 2012;104(12):899-905 - PMID: 22572994 - PMCID: PMC3379722 - DOI: 10.1093/jnci/djs239
Goel S, Fukumura D, Jain RK
Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology.
Proc Natl Acad Sci U S A. 2012;109(20):E1214 - PMID: 22550180 - PMCID: PMC3356659 - DOI: 10.1073/pnas.1203794109
Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Nat Nanotechnol. 2012;7(6):383-8 - PMID: 22484912 - PMCID: PMC3370066 - DOI: 10.1038/nnano.2012.45
Vakoc BJ, Fukumura D, Jain RK, Bouma BE
Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.
Nat Rev Cancer. 2012;12(5):363-8 - PMID: 22475930 - PMCID: PMC3560400 - DOI: 10.1038/nrc3235
Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D
Multistage nanoparticles for improved delivery into tumor tissue.
Methods Enzymol. 2012;508:109-30 - PMID: 22449923 - PMCID: PMC3774840 - DOI: 10.1016/B978-0-12-391860-4.00006-9
Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D
A transient parabiosis skin transplantation model in mice.
Nat Protoc. 2012;7(4):763-70 - PMID: 22441295 - PMCID: PMC3375333 - DOI: 10.1038/nprot.2012.032
Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG
Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
Nat Protoc. 2012;7(4):756-62 - PMID: 22441294 - PMCID: PMC3380105 - DOI: 10.1038/nprot.2012.031
Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK
An isolated tumor perfusion model in mice.
Nat Protoc. 2012;7(4):749-55 - PMID: 22441293 - PMCID: PMC3375334 - DOI: 10.1038/nprot.2012.030
Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK
Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).
PLoS One. 2012;7(2):e26331 - PMID: 22347360 - PMCID: PMC3274514 - DOI: 10.1371/journal.pone.0026331
Saylor PJ, Kozak KR, Smith MR, Ancukiewicz MA, Efstathiou JA, Zietman AL, Jain RK, Duda DG
Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer.
Oncologist. 2012;17(2):212-9 - PMID: 22302227 - PMCID: PMC3286170 - DOI: 10.1634/theoncologist.2011-0321
Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Boucher Y, Jain RK, Munn LL
Mechanical compression drives cancer cells toward invasive phenotype.
Proc Natl Acad Sci U S A. 2012;109(3):911-6 - PMID: 22203958 - PMCID: PMC3271885 - DOI: 10.1073/pnas.1118910109
Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK
Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.
Angew Chem Int Ed Engl. 2011;50(48):11417-20 - PMID: 22113800 - PMCID: PMC3260125 - DOI: 10.1002/anie.201104449
Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP
Impaired lymphatic contraction associated with immunosuppression.
Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108
Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LL
Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.
Blood. 2011;118(17):4740-9 - PMID: 21835951 - PMCID: PMC3208287 - DOI: 10.1182/blood-2011-02-338426
Horowitz NS, Penson RT, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Cohen KS, Berlin S, Krasner CN, Moses MA, Jain RK
Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Clin Ovarian Cancer Other Gynecol Malig. 2011;4(1):26-33 - PMID: 21833345 - PMCID: PMC3151740 - DOI: 10.1016/j.cloc.2011.04.003
Dawson MR, Chae SS, Jain RK, Duda DG
Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
Am J Cancer Res. 2011;1(2):144-54 - PMID: 21822499 - PMCID: PMC3150110
Huang P, Westmoreland SV, Jain RK, Fukumura D
Spontaneous nonthymic tumors in SCID mice.
Comp Med. 2011;61(3):227-34 - PMID: 21819692 - PMCID: PMC3123755
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Normalization of the vasculature for treatment of cancer and other diseases.
Physiol Rev. 2011;91(3):1071-121 - PMID: 21742796 - PMCID: PMC3258432 - DOI: 10.1152/physrev.00038.2010
Kozin SV, Duda DG, Munn LL, Jain RK
Is vasculogenesis crucial for the regrowth of irradiated tumours?
Nat Rev Cancer. 2011;11(7):532 - PMID: 21701514 - PMCID: PMC4790119 - DOI: 10.1038/nrc2007-c1
Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cancer Res. 2011;71(13):4527-38 - PMID: 21571860 - DOI: 10.1158/0008-5472.CAN-10-4376
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