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Baxter LT, Yuan F, Jain RK

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Cancer Res. 1992;52(20):5838-44 - PMID: 1394212

Hagendoorn J, Yock TI, Borel Rinkes IH, Padera TP, Ebb DH

Novel molecular pathways in Gorham disease: Implications for treatment.
Pediatr Blood Cancer. 2014;61(3):401-6 - PMID: 24214028 - PMCID: PMC4123459 - DOI: 10.1002/pbc.24832

Melder RJ, Jain RK

Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells.
Cell Biophys. 1994;20(2-3):161-76 - PMID: 1285298 - DOI: 10.1007/BF02823656

Weissbrod JM, Jain RK, Sirotnak FM

Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.
J Pharmacokinet Biopharm. 1978;6(6):487-503 - PMID: 731413 - DOI: 10.1007/BF01062105

Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA

Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Proc Natl Acad Sci U S A. 2014;111(30):E3091-100 - PMID: 25024225 - PMCID: PMC4121834 - DOI: 10.1073/pnas.1411679111

Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure.
Cancer Cell. 2014;26(1):14-15 - PMID: 25026209 - PMCID: PMC4381566 - DOI: 10.1016/j.ccr.2014.06.003

Jain RK, Martin JD, Stylianopoulos T

The role of mechanical forces in tumor growth and therapy.
Annu Rev Biomed Eng. 2014;16:321-46 - PMID: 25014786 - PMCID: PMC4109025 - DOI: 10.1146/annurev-bioeng-071813-105259

Wang Y, Li W, Patel SS, Cong J, Zhang N, Sabbatino F, Liu X, Qi Y, Huang P, Lee H, Taghian A, Li JJ, DeLeo AB, Ferrone S, Epperly MW, Ferrone CR, Ly A, Brachtel EF, Wang X

Blocking the formation of radiation-induced breast cancer stem cells.
Oncotarget. 2014;5(11):3743-55 - PMID: 25003837 - PMCID: PMC4116517 - DOI: 10.18632/oncotarget.1992

Munn LL, Padera TP

Imaging the Lymphatic System.
Microvasc Res. 2014;96C:55-63 - PMID: 24956510 - PMCID: PMC4268344 - DOI: 10.1016/j.mvr.2014.06.006

Hato T, Goyal L, Greten TF, Duda DG, Zhu AX

Immune checkpoint blockade in hepatocellular carcinoma: Current progress and future directions.
Hepatology. 2014;60(5):1776-82 - PMID: 24912948 - PMCID: PMC4211962 - DOI: 10.1002/hep.27246

Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-Del Castillo C, Duda DG

A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma.
Int J Radiat Oncol Biol Phys. 2014;89(4):830-8 - PMID: 24867540 - PMCID: PMC4791180 - DOI: 10.1016/j.ijrobp.2014.03.034

Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK

Hypermutable DNA chronicles the evolution of human colon cancer.
Proc Natl Acad Sci U S A. 2014;111(18):E1889-98 - PMID: 24753616 - PMCID: PMC4020055 - DOI: 10.1073/pnas.1400179111

Cucu D, Chiritoiu G, Petrescu S, Babes A, Stanica L, Duda DG, Horii A, Dima SO, Popescu I

Characterization of Functional Transient Receptor Potential Melastatin 8 Channels in Human Pancreatic Ductal Adenocarcinoma Cells.
Pancreas. 2014;43(5):795-800 - PMID: 24658318 - DOI: 10.1097/MPA.0000000000000106

Jain RK

1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Ann Biomed Eng. 1996;24(4):457-73 - PMID: 8841721 - DOI: 10.1007/BF02648108

Dellian M, Helmlinger G, Yuan F, Jain RK

Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.
Br J Cancer. 1996;74(8):1206-15 - PMID: 8883406 - PMCID: PMC2075944 - DOI: 10.1038/bjc.1996.518

Johnson ME, Berk DA, Blankschtein D, Golan DE, Jain RK, Langer RS

Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Biophys J. 1996;71(5):2656-68 - PMID: 8913603 - PMCID: PMC1233752 - DOI: 10.1016/S0006-3495(96)79457-2

Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Proc Natl Acad Sci U S A. 1996;93(25):14765-70 - PMID: 8962129 - PMCID: PMC26210 - DOI: 10.1073/pnas.93.25.14765

Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK

Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Microvasc Res. 1996;51(3):327-46 - PMID: 8992232 - DOI: 10.1006/mvre.1996.0031

Helmlinger G, Yuan F, Dellian M, Jain RK

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Nat Med. 1997;3(2):177-82 - PMID: 9018236 - DOI: 10.1038/nm0297-177

Berk DA, Yuan F, Leunig M, Jain RK

Direct in vivo measurement of targeted binding in a human tumor xenograft.
Proc Natl Acad Sci U S A. 1997;94(5):1785-90 - PMID: 9050856 - PMCID: PMC19994 - DOI: 10.1073/pnas.94.5.1785

Briscoe DM, Ganz P, Alexander SI, Melder RJ, Jain RK, Cotran RS, Lichtman AH

The problem of chronic rejection: influence of leukocyte-endothelial interactions.
Kidney Int Suppl. 1997;58:S22-7 - PMID: 9067938

Lichtenbeld HC, Yuan F, Michel CC, Jain RK

Perfusion of single tumor microvessels: application to vascular permeability measurement.
Microcirculation. 1996;3(4):349-57 - PMID: 9086446 - DOI: 10.3109/10739689609148307

Jain RK

The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.
Microcirculation. 1997;4(1):1-23 - PMID: 9110280 - DOI: 10.3109/10739689709148314

Less JR, Posner MC, Skalak TC, Wolmark N, Jain RK

Geometric resistance and microvascular network architecture of human colorectal carcinoma.
Microcirculation. 1997;4(1):25-33 - PMID: 9110281 - DOI: 10.3109/10739689709148315

Baish JW, Netti PA, Jain RK

Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Microvasc Res. 1997;53(2):128-41 - PMID: 9143544 - DOI: 10.1006/mvre.1996.2005

Leunig M, Yuan F, Gerweck LE, Jain RK

Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice.
Int J Microcirc Clin Exp. 1997;17(1):1-9 - PMID: 9176719 - DOI: 10.1159/000179199

Helmlinger G, Netti PA, Lichtenbeld HC, Melder RJ, Jain RK

Solid stress inhibits the growth of multicellular tumor spheroids.
Nat Biotechnol. 1997;15(8):778-83 - PMID: 9255794 - DOI: 10.1038/nbt0897-778

Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, Dewhirst MW, Milross CG, Milas L, Song CW, Thomas CD, Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, Suit HD

Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.
J Surg Oncol. 1997;66(1):30-8 - PMID: 9290690 - DOI: 10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o

Griffon-Etienne G, Boucher Y, Jain RK, Suit HD

Effects of needle insertion in tumors on interstitial fluid pressure.
Microvasc Res. 1997;54(2):174-7 - PMID: 9327388 - DOI: 10.1006/mvre.1997.2037

Jain RK, Schlenger K, Höckel M, Yuan F

Quantitative angiogenesis assays: progress and problems.
Nat Med. 1997;3(11):1203-8 - PMID: 9359693 - DOI: 10.1038/nm1197-1203

Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, Jain RK

Fractal characteristics of tumor vascular architecture during tumor growth and regression.
Microcirculation. 1997;4(4):395-402 - PMID: 9431507 - DOI: 10.3109/10739689709146803

Zhu H, Jain RK, Baxter LT

Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
J Nucl Med. 1998;39(1):65-76 - PMID: 9443740

Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
Proc Natl Acad Sci U S A. 1998;95(8):4607-12 - PMID: 9539785 - PMCID: PMC22537 - DOI: 10.1073/pnas.95.8.4607

Hunter GJ, Hamberg LM, Choi N, Jain RK, McCloud T, Fischman AJ

Dynamic T1-weighted magnetic resonance imaging and positron emission tomography in patients with lung cancer: correlating vascular physiology with glucose metabolism.
Clin Cancer Res. 1998;4(4):949-55 - PMID: 9563889

Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R

Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.
Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01

Rosenzweig M, DeMaria MA, Harper DM, Friedrich S, Jain RK, Johnson RP

Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques.
Proc Natl Acad Sci U S A. 1998;95(11):6388-93 - PMID: 9600975 - PMCID: PMC27734 - DOI: 10.1073/pnas.95.11.6388

Jain RK

Integrative pathophysiology of solid tumors: role in detection and treatment.
Cancer J Sci Am. 1998;4 Suppl 1:S48-57 - PMID: 9619271

Jain RK

The next frontier of molecular medicine: delivery of therapeutics.
Nat Med. 1998;4(6):655-7 - PMID: 9623964 - DOI: 10.1038/nm0698-655

Jain RK, Safabakhsh N, Sckell A, Chen Y, Jiang P, Benjamin L, Yuan F, Keshet E

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor.
Proc Natl Acad Sci U S A. 1998;95(18):10820-5 - PMID: 9724788 - PMCID: PMC27979 - DOI: 10.1073/pnas.95.18.10820

Baish JW, Jain RK

Cancer, angiogenesis and fractals.
Nat Med. 1998;4(9):984 - PMID: 9734370 - DOI: 10.1038/1952

Jain RK

Delivery of molecular and cellular medicine to solid tumors.
J Control Release. 1998;53(1-3):49-67 - PMID: 9741913 - DOI: 10.1016/s0168-3659(97)00237-x

Kristjansen PE, Brown TJ, Shipley LA, Jain RK

Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.
Clin Cancer Res. 1996;2(2):359-67 - PMID: 9816179

Sckell A, Safabakhsh N, Dellian M, Jain RK

Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice.
Cancer Res. 1998;58(24):5866-9 - PMID: 9865747

Kristensen CA, Askenasy N, Jain RK, Koretsky AP

Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies.
Br J Cancer. 1999;79(2):278-85 - PMID: 9888469 - PMCID: PMC2362210 - DOI: 10.1038/sj.bjc.6690045

Kristensen CA, Roberge S, Jain RK

Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts.
Clin Cancer Res. 1997;3(3):319-24 - PMID: 10026014

Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK

Return of lymphatic function after flap transfer for acute lymphedema.
Ann Surg. 1999;229(3):421-7 - PMID: 10077056 - PMCID: PMC1191709 - DOI: 10.1097/00000658-199903000-00017

Moulton KS, Melder RJ, Dharnidharka VR, Hardin-Young J, Jain RK, Briscoe DM

Angiogenesis in the huPBL-SCID model of human transplant rejection.
Transplantation. 1999;67(12):1626-31 - PMID: 10401773 - DOI: 10.1097/00007890-199906270-00020

Jain RK

Understanding barriers to drug delivery: high resolution in vivo imaging is key.
Clin Cancer Res. 1999;5(7):1605-6 - PMID: 10430057

Endo M, Jain RK, Witwer B, Brown D

Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas.
Microvasc Res. 1999;58(2):89-98 - PMID: 10458924 - DOI: 10.1006/mvre.1999.2158

Heijn M, Roberge S, Jain RK

Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor.
Cancer Res. 1999;59(17):4458-63 - PMID: 10485498
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