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Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT

Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
J Neurooncol. 2011;103(2):325-32 - PMID: 20821342 - PMCID: PMC4090923 - DOI: 10.1007/s11060-010-0390-7

Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK

Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Biophys J. 2010;99(5):1342-9 - PMID: 20816045 - PMCID: PMC2931749 - DOI: 10.1016/j.bpj.2010.06.016

Brown E, Munn LL, Fukumura D, Jain RK

In vivo imaging of tumors.
Cold Spring Harb Protoc. 2010;2010(7):pdb.prot5452 - PMID: 20647356 - PMCID: PMC3891051 - DOI: 10.1101/pdb.prot5452

Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
Nat Methods. 2010;7(8):655-60 - PMID: 20581828 - PMCID: PMC2921873 - DOI: 10.1038/nmeth.1475

Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D

Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Clin Cancer Res. 2010;16(14):3618-27 - PMID: 20501615 - PMCID: PMC2905497 - DOI: 10.1158/1078-0432.CCR-09-3073

Fukumura D, Duda DG, Munn LL, Jain RK

Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Microcirculation. 2010;17(3):206-25 - PMID: 20374484 - PMCID: PMC2859831 - DOI: 10.1111/j.1549-8719.2010.00029.x

Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH

In vivo wide-area cellular imaging by side-view endomicroscopy.
Nat Methods. 2010;7(4):303-5 - PMID: 20228814 - PMCID: PMC2849759 - DOI: 10.1038/nmeth.1440

Choi B, Bouma B, Fukumura D, Jain RK

Optical methods in vascular biology and medicine.
J Biomed Opt. 2010;15(1):011001 - PMID: 20210426 - DOI: 10.1117/1.3338696

Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG

Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
J Am Chem Soc. 2010;132(2):472-83 - PMID: 20025223 - PMCID: PMC2871316 - DOI: 10.1021/ja908137d

Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG

InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
J Am Chem Soc. 2010;132(2):470-1 - PMID: 20025222 - PMCID: PMC2862004 - DOI: 10.1021/ja908250r

Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK

Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
PLoS One. 2009;4(12):e8316 - PMID: 20016816 - PMCID: PMC2789383 - DOI: 10.1371/journal.pone.0008316

Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Cancer Res. 2009;69(20):7905-10 - PMID: 19826039 - PMCID: PMC2859041 - DOI: 10.1158/0008-5472.CAN-09-2099

Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK

VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
PLoS One. 2009;4(9):e6525 - PMID: 19763275 - PMCID: PMC2744279 - DOI: 10.1371/journal.pone.0006525

Dawson MR, Duda DG, Fukumura D, Jain RK

VEGFR1-activity-independent metastasis formation.
Nature. 2009;461(7262):E4; discussion E5 - PMID: 19759568 - PMCID: PMC3065241 - DOI: 10.1038/nature08254

Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971

Jain RK, Munn LL, Fukumura D, Melder RJ

In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.
Methods Mol Med. 2011;18:553-75 - PMID: 21370203 - DOI: 10.1385/0-89603-516-6:553

Jain RK, Munn LL, Fukumura D

Rabbit ear chambers.
Cold Spring Harb Protoc. 2012;2012(7):813-14 - PMID: 22753607 - DOI: 10.1101/pdb.prot070045

Less JR, Skalak TC, Sevick EM, Jain RK

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
Cancer Res. 1991;51(1):265-73 - PMID: 1988088

Ohkubo C, Bigos D, Jain RK

Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.
Cancer Res. 1991;51(5):1561-3 - PMID: 1997196

Sevick EM, Jain RK

Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Cancer Res. 1991;51(10):2727-30 - PMID: 2021951

Yuan F, Baxter LT, Jain RK

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Cancer Res. 1991;51(12):3119-30 - PMID: 2039991

Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Microvasc Res. 1990;40(2):246-63 - PMID: 2250603 - DOI: 10.1016/0026-2862(90)90023-k

Jain RK, Stock RJ, Chary SR, Rueter M

Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.
Microvasc Res. 1990;39(1):77-93 - PMID: 2314308 - DOI: 10.1016/0026-2862(90)90060-5

Boucher Y, Baxter LT, Jain RK

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer Res. 1990;50(15):4478-84 - PMID: 2369726

Gerlowski LE, Jain RK

Microvascular permeability of normal and neoplastic tissues.
Microvasc Res. 1986;31(3):288-305 - PMID: 2423854 - DOI: 10.1016/0026-2862(86)90018-x

Sasaki A, Jain RK, Maghazachi AA, Goldfarb RH, Herberman RB

Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.
Cancer Res. 1989;49(14):3742-6 - PMID: 2500233

Sevick EM, Jain RK

Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.
Cancer Res. 1989;49(13):3513-9 - PMID: 2731173

Baxter LT, Jain RK

Vascular permeability and interstitial diffusion in superfused tissues: a two-dimensional model.
Microvasc Res. 1988;36(1):108-15 - PMID: 3185299 - DOI: 10.1016/0026-2862(88)90043-x

Jain RK, Baxter LT

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Cancer Res. 1988;48(24 Pt 1):7022-32 - PMID: 3191477

Sevick EM, Jain RK

Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.
Cancer Res. 1988;48(5):1201-7 - PMID: 3342400

DiPette DJ, Ward KA, Jain RK, Kerr NE, Schwarzenberger K

Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1988;48(6):1476-80 - PMID: 3345521

Jain RK

Transport of molecules in the tumor interstitium: a review.
Cancer Res. 1987;47(12):3039-51 - PMID: 3555767

Jain RK, Ward-Hartley KA

Dynamics of cancer cell interactions with microvasculature and interstitium.
Biorheology. 1987;24(2):117-25 - PMID: 3651585 - DOI: 10.3233/bir-1987-24205

DiPette DJ, Ward-Hartley KA, Jain RK

Effect of glucose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1986;46(12 Pt 1):6299-304 - PMID: 3779648

Nugent LJ, Jain RK

Two-compartment model for plasma pharmacokinetics in individual blood vessels.
J Pharmacokinet Biopharm. 1984;12(4):451-61 - PMID: 6084709 - DOI: 10.1007/BF01062668

Nugent LJ, Jain RK

Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues.
Microvasc Res. 1984;28(2):270-4 - PMID: 6209533 - DOI: 10.1016/0026-2862(84)90022-0

Jain RK, Shah SA, Finney PL

Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia.
J Natl Cancer Inst. 1984;73(2):429-36 - PMID: 6589435 - DOI: 10.1093/jnci/73.2.429

Jain RK, Weissbrod JM, Wei J

Mass transport in tumors: characterization and applications to chemotherapy.
Adv Cancer Res. 1981;33:251-310 - PMID: 7006335 - DOI: 10.1016/s0065-230x(08)60672-7

Johnson EM, Berk DA, Jain RK, Deen WM

Diffusion and partitioning of proteins in charged agarose gels.
Biophys J. 1995;68(4):1561-8 - PMID: 7787041 - PMCID: PMC1282050 - DOI: 10.1016/S0006-3495(95)80328-0

Neelamegham S, Munn LL, Zygourakis K

A model for the kinetics of homotypic cellular aggregation under static conditions.
Biophys J. 1997;72(1):51-64 - PMID: 8994592 - PMCID: PMC1184296 - DOI: 10.1016/S0006-3495(97)78646-6

Zhu H, Baxter LT, Jain RK

Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.
J Nucl Med. 1997;38(5):731-41 - PMID: 9170438

Gazit Y, Berk DA, Leunig M, Baxter LT, Jain RK

Scale-invariant behavior and vascular network formation in normal and tumor tissue.
Phys Rev Lett. 1995;75(12):2428-2431 - PMID: 10059301 - DOI: 10.1103/PhysRevLett.75.2428

Pluen A, Netti PA, Jain RK, Berk DA

Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations.
Biophys J. 1999;77(1):542-52 - PMID: 10388779 - PMCID: PMC1300351 - DOI: 10.1016/S0006-3495(99)76911-0

Somasundaran P, Simpson S, Jain RK, Ivanov I, Raghuraman V

Investigation of Thin Aqueous Films on Silica Using a Modified Interferometric Technique.
J Colloid Interface Sci. 2000;225(1):243-246 - PMID: 10767167 - DOI: 10.1006/jcis.2000.6735

Jain RK

Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 1997;26(2-3):71-90 - PMID: 10837535 - DOI: 10.1016/s0169-409x(97)00027-6

Kaur A, Hale CL, Ramanujan S, Jain RK, Johnson RP

Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection.
J Virol. 2000;74(18):8413-24 - PMID: 10954541 - PMCID: PMC116352 - DOI: 10.1128/jvi.74.18.8413-8424.2000

Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.
Proc Natl Acad Sci U S A. 2001;98(5):2604-9 - PMID: 11226286 - PMCID: PMC30185 - DOI: 10.1073/pnas.041359198

Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA

A potential murine model for flap-related investigations.
Plast Reconstr Surg. 2001;107(6):1504-8 - PMID: 11335827 - DOI: 10.1097/00006534-200105000-00032

Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK

LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer Res. 2001;61(22):8079-84 - PMID: 11719431

Friedrich SW, Lin SC, Stoll BR, Baxter LT, Munn LL, Jain RK

Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.
Neoplasia. 2002;4(5):449-63 - PMID: 12192604 - PMCID: PMC1661679 - DOI: 10.1038/sj.neo.7900260
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