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Nugent LJ, Jain RK

Extravascular diffusion in normal and neoplastic tissues.
Cancer Res. 1984;44(1):238-44 - PMID: 6197161

Gerlowski LE, Jain RK

Physiologically based pharmacokinetic modeling: principles and applications.
J Pharm Sci. 1983;72(10):1103-27 - PMID: 6358460 - DOI: 10.1002/jps.2600721003

Shah SA, Jain RK, Finney PL

Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma.
Cancer Lett. 1983;19(3):317-23 - PMID: 6883314 - DOI: 10.1016/0304-3835(83)90101-5

Dudar TE, Jain RK

Microcirculatory flow changes during tissue growth.
Microvasc Res. 1983;25(1):1-21 - PMID: 6188025 - DOI: 10.1016/0026-2862(83)90040-7

Nugent LJ, Jain RK

Monitoring transport in the rabbit ear chamber.
Microvasc Res. 1982;24(2):204-9 - PMID: 7176939 - DOI: 10.1016/0026-2862(82)90057-7

Volpe BT, Jain RK

Temperature distributions and thermal response in humans. I. Simulations of various modes of whole-body hyperthermia in normal subjects.
Med Phys. 1982;9(4):506-13 - PMID: 7110081 - DOI: 10.1118/1.595115

Gullino PM, Jain RK, Grantham FH

Temperature gradients and local perfusion in a mammary carcinoma.
J Natl Cancer Inst. 1982;68(3):519-33 - PMID: 6950181

Shah SA, Jain RK, Finney PL

Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma.
Adv Exp Med Biol. 1983;157:23-42 - PMID: 7158522 - DOI: 10.1007/978-1-4684-4388-2_4

Zawicki DF, Jain RK, Schmid-Schoenbein GW, Chien S

Dynamics of neovascularization in normal tissue.
Microvasc Res. 1981;21(1):27-47 - PMID: 7010086 - DOI: 10.1016/0026-2862(81)90003-0

Chryanthopoulos GS, Jain RK

Thermal interactions between normal and neoplastic tissues in the rat, rabbit, swine, and dog during hyperthermia.
Med Phys. 1980;7(5):529-39 - PMID: 7421764 - DOI: 10.1118/1.594668

Weissbrod JM, Jain RK

Preliminary model for streptozocin metabolism in mice.
J Pharm Sci. 1980;69(6):691-4 - PMID: 6451687 - DOI: 10.1002/jps.2600690621

Jain RK, Grantham FH, Gullino PM

Blood flow and heat transfer in Walker 256 mammary carcinoma.
J Natl Cancer Inst. 1979;62(4):927-33 - PMID: 285296

Jain RK

Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia.
Ann N Y Acad Sci. 1980;335:48-66 - PMID: 6931539 - DOI: 10.1111/j.1749-6632.1980.tb50736.x

Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK

Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
Proc Natl Acad Sci U S A. 2013;110(31):12774-9 - PMID: 23861493 - PMCID: PMC3732948 - DOI: 10.1073/pnas.1310675110

Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164

Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, Mason W, Mikkelsen T, Phuphanich S, Ashby LS, Degroot J, Gattamaneni R, Cher L, Rosenthal M, Payer F, Jürgensmeier JM, Jain RK, Sorensen AG, Xu J, Liu Q, van den Bent M

Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma.
J Clin Oncol. 2013;31(26):3212-3218 - PMID: 23940216 - PMCID: PMC4021043 - DOI: 10.1200/JCO.2012.47.2464

Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG

Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
Nat Med. 2013;19(9):1178-83 - PMID: 23955713 - PMCID: PMC3769525 - DOI: 10.1038/nm.3289

Liao S, Padera TP

Lymphatic Function and Immune Regulation in Health and Disease.
Lymphat Res Biol. 2013;11(3):136-43 - PMID: 24024577 - PMCID: PMC3780287 - DOI: 10.1089/lrb.2013.0012

Qazi H, Palomino R, Shi ZD, Munn LL, Tarbell JM

Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion.
Integr Biol (Camb). 2013;5(11):1334-43 - PMID: 24077103 - PMCID: PMC4249644 - DOI: 10.1039/c3ib40057c

Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Nat Commun. 2013;4:2516 - PMID: 24084631 - PMCID: PMC3806395 - DOI: 10.1038/ncomms3516

Zhu AX, Finn RS, Mulcahy M, Gurtler J, Sun W, Schwartz JD, Dalal RP, Joshi A, Hozak RR, Xu Y, Ancukiewicz M, Jain RK, Nugent F, Duda DG, Stuart K

A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2 in Patients with Advanced Hepatocellular Cancer.
Clin Cancer Res. 2013;19(23):6614-23 - PMID: 24088738 - PMCID: PMC4795808 - DOI: 10.1158/1078-0432.CCR-13-1442

Lemon CM, Curtin PN, Somers RC, Greytak AB, Lanning RM, Jain RK, Bawendi MG, Nocera DG

Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.
Inorg Chem. 2014;53(4):1900-15 - PMID: 24143874 - PMCID: PMC3944830 - DOI: 10.1021/ic401587r

Chauhan VP, Jain RK

Strategies for advancing cancer nanomedicine.
Nat Mater. 2013;12(11):958-62 - PMID: 24150413 - PMCID: PMC4120281 - DOI: 10.1038/nmat3792

Stylianopoulos T, Jain RK

Combining two strategies to improve perfusion and drug delivery in solid tumors.
Proc Natl Acad Sci U S A. 2013;110(46):18632-7 - PMID: 24167277 - PMCID: PMC3832007 - DOI: 10.1073/pnas.1318415110

Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, Corcoran RB, Rivera MN, Ramaswamy S, Hung KE, Benes CH, Engelman JA

mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL inhibition by Suppressing MCL-1.
Cancer Discov. 2014;4(1):42-52 - PMID: 24163374 - PMCID: PMC3973435 - DOI: 10.1158/2159-8290.CD-13-0315

Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK

Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Proc Natl Acad Sci U S A. 2013;110(47):19059-64 - PMID: 24190997 - PMCID: PMC3839699 - DOI: 10.1073/pnas.1318022110

Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP

Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells.
Angiogenesis. 2014;17(2):419-27 - PMID: 24201897 - PMCID: PMC3981926 - DOI: 10.1007/s10456-013-9400-7

Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK

Targeted therapy in rectal cancer.
Oncology (Williston Park). 2007;21(9):1055-65; discussion 1065, 1070, 1075 passim - PMID: 17910311 - PMCID: PMC2686129

Jain RK, Xu L

alphaPlGF: a new kid on the antiangiogenesis block.
Cell. 2007;131(3):443-5 - PMID: 17981110 - DOI: 10.1016/j.cell.2007.10.023

Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK

Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.
Blood. 2008;111(3):1302-5 - PMID: 17993613 - PMCID: PMC2214740 - DOI: 10.1182/blood-2007-06-094318

Mok W, Boucher Y, Jain RK

Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107

Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT

Antiangiogenic agents for the treatment of glioblastoma.
Expert Opin Investig Drugs. 2007;16(12):1895-908 - PMID: 18041999 - DOI: 10.1517/13543784.16.12.1895

Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK

Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938 - DOI: 10.1593/neo.07643

Au P, Tam J, Fukumura D, Jain RK

Small blood vessel engineering.
Methods Mol Med. 2007;140:183-95 - PMID: 18085210 - DOI: 10.1007/978-1-59745-443-8_11

Munn LL, Dupin MM

Blood cell interactions and segregation in flow.
Ann Biomed Eng. 2008;36(4):534-44 - PMID: 18188702 - PMCID: PMC2752714 - DOI: 10.1007/s10439-007-9429-0

Jain RK

Taming vessels to treat cancer.
Sci Am. 2008;298(1):56-63 - PMID: 18225696 - DOI: 10.1038/scientificamerican0108-56

Au P, Tam J, Fukumura D, Jain RK

Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.
Blood. 2008;111(9):4551-8 - PMID: 18256324 - PMCID: PMC2343592 - DOI: 10.1182/blood-2007-10-118273

Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D

Perivascular nitric oxide gradients normalize tumor vasculature.
Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730

Jones RC, Capen D, Petersen B, Jain RK, Duda DG

A protocol for a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):378-87 - PMID: 18323809 - PMCID: PMC2676330 - DOI: 10.1038/nprot.2007.536

Jones RC, Capen DE, Cohen KS, Munn LL, Jain RK, Duda DG

A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):388-97 - PMID: 18323810 - PMCID: PMC2676340 - DOI: 10.1038/nprot.2007.537

Jain RK

Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.
Nat Rev Cancer. 2008;8(4):309-16 - PMID: 18337733 - DOI: 10.1038/nrc2346

Nagano S, Perentes JY, Jain RK, Boucher Y

Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer Res. 2008;68(10):3795-802 - PMID: 18483263 - PMCID: PMC2871708 - DOI: 10.1158/0008-5472.CAN-07-6193

Huang P, Duda DG, Jain RK, Fukumura D

Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079

Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182

Padera TP, Jain RK

VEGFR3: a new target for antiangiogenesis therapy?
Dev Cell. 2008;15(2):178-9 - PMID: 18694556 - PMCID: PMC4790102 - DOI: 10.1016/j.devcel.2008.07.014

Sorensen AG, Batchelor TT, Wen PY, Zhang WT, Jain RK

Response criteria for glioma.
Nat Clin Pract Oncol. 2008;5(11):634-44 - PMID: 18711427 - PMCID: PMC4795821 - DOI: 10.1038/ncponc1204

Fukumura D, Jain RK

Imaging angiogenesis and the microenvironment.
APMIS. 2008;116(7-8):695-715 - PMID: 18834413 - PMCID: PMC2859845 - DOI: 10.1111/j.1600-0463.2008.01148.x

Gerstner ER, Sorensen AG, Jain RK, Batchelor TT

Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.
Curr Opin Neurol. 2008;21(6):728-35 - PMID: 18989120 - DOI: 10.1097/WCO.0b013e328318402a

Tam J, Fukumura D, Jain RK

A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.
Cell Metab. 2009;9(1):52-63 - PMID: 19117546 - PMCID: PMC2643084 - DOI: 10.1016/j.cmet.2008.11.005

Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nat Methods. 2009;6(2):143-5 - PMID: 19151720 - PMCID: PMC2877598 - DOI: 10.1038/nmeth.1295
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